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Clinical Applications of Nuclear Medicine Targeted Therapy pp 323–343Cite as

Bone Metastases in Prostate Cancer

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Abstract

Bone metastases occur in more than 80% of men with metastatic prostate cancer. Affecting the structural integrity of the bone, they can lead to skeletal complications and pain, with a negative impact on patient quality of life and survival. The last decade has witnessed tremendous advances in the treatment of metastatic PCa. New therapeutic options that prolong overall survival are now available. The optimization of bone metastasis management (and prevention of skeletal morbidities) is therefore of paramount importance to improve clinical outcome. Some issues are still debated, such as the most effective radiologic or nuclear medicine technique to diagnose and monitor bone disease, the ideal surrogate circulating marker to assess response or progression to treatment, patient selection, as well as the optimal sequencing or combination of available therapeutic options. Several healthcare professionals play a role in the treatment of metastatic PCa. The presence of a multidisciplinary team for the discussion of treatment strategies for each patient should be the standard of care.

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Authors and Affiliations

  1. Department of Medical Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy

    Maria Bonomi, Eleonora Cerchiaro, Letizia Gianoncelli & Giovanni Luca Ceresoli

  2. Department of Radiation Oncology, Cliniche Humanitas Gavazzeni, Bergamo, Italy

    Elisa Villa

  3. Department of Nuclear Medicine, Cliniche Humanitas Gavazzeni, Bergamo, Italy

    Lucia Rebecca Setti

  4. Department of Urology, Cliniche Humanitas Gavazzeni, Bergamo, Italy

    Emanuele Micheli

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  1. Maria Bonomi
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  2. Eleonora Cerchiaro
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  3. Elisa Villa
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  4. Lucia Rebecca Setti
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  5. Letizia Gianoncelli
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  6. Emanuele Micheli
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  7. Giovanni Luca Ceresoli
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Correspondence to Maria Bonomi .

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Editors and Affiliations

  1. Department of Nuclear Medicine, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Emilio Bombardieri

  2. Nuclear Medicine Therapy and Endocrinology, Istituto Nazionale dei Tumori, Milano, Italy

    Ettore Seregni

  3. Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy

    Laura Evangelista

  4. Nuclear Medicine Division, Istituto Nazionale dei Tumori, Milano, Italy

    Carlo Chiesa

  5. Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milano, Italy

    Arturo Chiti

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Bonomi, M. et al. (2018). Bone Metastases in Prostate Cancer. In: Bombardieri, E., Seregni, E., Evangelista, L., Chiesa, C., Chiti, A. (eds) Clinical Applications of Nuclear Medicine Targeted Therapy . Springer, Cham. https://doi.org/10.1007/978-3-319-63067-0_25

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