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Radiopharmaceuticals for Therapy of Thyroid Diseases

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Clinical Applications of Nuclear Medicine Targeted Therapy

Abstract

Since the discovery of radium, the medical community has been interested in the application of unsealed radioactive isotopes to target and treat cancer and benign proliferative conditions. Radioactive iodine-131, as non radioactive Iodine, is taken up by thyroid cells, either normal or pathological, therefore thanks to its gamma and beta emissions, represents a radiopharmaceutical of choice for thyroid diseases. We give here a summary of the chemistry, mechanism of uptake and biodistribution of 131-Iodine with regard of its applications in thyroid benign and malignant diseases.The medical community has been interested in the application of unsealed radioactive isotopes to target and treat cancer and benign systemic and locoregional proliferative conditions. Lack of effective system agents coupled with the intention to use targeted therapy for treating cancer made radioisotopes an option for use in cancer.

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Author information

Authors and Affiliations

  1. Humanitas Research Hospital, Rozzano, MI, Italy

    Katia Marzo

Authors
  1. Katia Marzo
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Correspondence to Katia Marzo .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine, Humanitas Gavazzeni Hospital, Bergamo, Italy

    Emilio Bombardieri

  2. Nuclear Medicine Therapy and Endocrinology, Istituto Nazionale dei Tumori, Milano, Italy

    Ettore Seregni

  3. Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy

    Laura Evangelista

  4. Nuclear Medicine Division, Istituto Nazionale dei Tumori, Milano, Italy

    Carlo Chiesa

  5. Nuclear Medicine, Humanitas Research Hospital, Rozzano, Milano, Italy

    Arturo Chiti

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Marzo, K. (2018). Radiopharmaceuticals for Therapy of Thyroid Diseases. In: Bombardieri, E., Seregni, E., Evangelista, L., Chiesa, C., Chiti, A. (eds) Clinical Applications of Nuclear Medicine Targeted Therapy . Springer, Cham. https://doi.org/10.1007/978-3-319-63067-0_2

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  • DOI: https://doi.org/10.1007/978-3-319-63067-0_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-63066-3

  • Online ISBN: 978-3-319-63067-0

  • eBook Packages: MedicineMedicine (R0)

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