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Medical Devices for Radioembolization

  • Anna Bogni
  • Claudio Pascali
Chapter

Abstract

Microspheres of the proper size injected into the hepatic artery lodge themselves preferentially in and around tumours as a result of both the increased vascularity of tumours and the fact that blood from the hepatic artery flows preferentially to malignancies. Thus, radioembolization with microspheres labelled with β-emitter radionuclides has become a well-established and powerful tool for the treatment of liver malignancies, since it adds to the embolization effect the deposition of lethal doses of radiation to the tumour cells.

Two commercially available medical devices of this type labelled with yttrium-90 (90Y) are presently authorized for human use. Although both are reportedly effective, they have key dissimilarities strictly related to their chemical form and manufacturing method. The aim of this chapter is to examine these factors in terms of pro and cons and how they can affect the use and biodistribution of radiolabelled microspheres.

Last, the need to have good in vivo imaging during pretreatment procedure, as well as during and/or after administration of the dose, has encouraged to explore alternative radionuclides to 90Y able to fulfil this requirement, such as holmium-166 (166Ho) and rhenium-186 and rhenium-188 (186Re/188Re). These, together with the development of different microsphere matrixes, will be also discussed.

Keywords

Yttrium-90 Holmium-166 Rhenium-186/Rhenium-188 Radiolabelled microspheres Radioembolization 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Fondazione IRCCS “Istituto dei Tumori”, Nuclear Medicine UnitMilanItaly

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