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Minor Papilla Cannulation and Endotherapy

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Diagnostic and Therapeutic Procedures in Gastroenterology

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Abstract

Most efforts to perform pancreatography for assessment of leaks, constriction, filling defects, or irregularity due to chronic pancreatitis are pursued through the major papilla at the ampullary junction with the bile duct. Endoscopic cannulation of the minor papilla is performed (a) when symptoms or imaging studies warrant attempts to diagnose and potentially treat anatomic variations of the pancreatic ductal system and (b) when access to the ventral duct at the major papilla fails or is inadequate to accomplish diagnostic or therapeutic goals in the upstream main duct. The normal development of pancreatic ductal anatomy occurs during the eighth week of gestation with the fusion of the ventral and dorsal pancreas and their respective ducts, resulting in formation of the main pancreatic duct which drains from the dorsal body and tail through the ventral duct of Wirsung in the head to the major papilla and the duodenum. The short segment of dorsal duct extending from the junction between the dorsal and ventral ducts at approximately the genu to the minor papilla becomes the accessory duct or duct of Santorini. The accessory duct and the minor papilla may be patent or only vestigial, without an appreciable lumen.

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References

  1. Kin T, Shapiro AM, Lakey JR. Pancreas divisum: a study of the cadaveric donor pancreas for islet isolation. Pancreas. 2005;30(4):325–7.

    Article  PubMed  Google Scholar 

  2. Yu J, Turner MA, Fulcher AS, Halvorsen RA. Congenital anomalies and normal variants of the pancreaticobiliary tract and the pancreas in adults: part 2, pancreatic duct and pancreas. AJR. Am J Roentgenol. 2006;187(6):1544–53.

    Article  Google Scholar 

  3. Gelrud A, Sheth S, Banerjee S, et al. Analysis of cystic fibrosis gener product (CFTR) function in patients with pancreas divisum and recurrent acute pancreatitis. Am J Gastroenterol. 2004;99(8):1557–62.

    Article  PubMed  Google Scholar 

  4. Garg PK, Khajuria R, Kabra M, Shastri SS. Association of SPINK1 gene mutation and CFTR gene polymorphisms in patients with pancreas divisum presenting with idiopathic pancreatitis. J Clin Gastroenterol. 2009;43(9):848–52.

    Article  CAS  PubMed  Google Scholar 

  5. Mosler P, Akisik F, Sandrasegaran K, et al. Accuracy of magnetic resonance cholangiopancreatography in the diagnosis of pancreas divisum. Dig Dis Sci. 2012;57(1):170–4.

    Article  PubMed  Google Scholar 

  6. Akisik MF, Sandrasegaran K, Aisen AA, Maglinte DD, Sherman S, Lehman GA. Dynamic secretin-enhanced MR cholangiopancreatography. Radiographics Rev Publ Radiol Soc North Am Inc. 2006;26(3):665–77.

    Google Scholar 

  7. Manfredi R, Pozzi MR. Secretin-enhanced MR imaging of the pancreas. Radiology. 2016;279(1):29–43.

    Article  PubMed  Google Scholar 

  8. Crino SF, Bernardoni L, Conti Bellocchi MC, et al. Efficacy of endoscopic minor papilla sphincterotomy for symptomatic santorinicele. Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc. 2017;15(2):303–6.

    Google Scholar 

  9. Lutzak GD, Gluck M, Ross AS, Kozarek RA. Endoscopic minor papilla sphincterotomy in patients with santoriniceles reduces pain and improves quality of life. Dig Dis Sci. 2013;58(7):2075–81.

    Article  CAS  PubMed  Google Scholar 

  10. Boninsegna E, Manfredi R, Ventriglia A, et al. Santorinicele: secretin-enhanced magnetic resonance cholangiopancreatography findings before and after minor papilla sphincterotomy. Eur Radiol. 2015;25(8):2437–44.

    Article  PubMed  Google Scholar 

  11. Dumonceau JM, Cremer M, Baize M, Deviere J. The transduodenal rendezvous: a new approach to deeply cannulate the main pancreatic duct. Gastrointest Endosc. 1999;50(2):274–6.

    Article  CAS  PubMed  Google Scholar 

  12. Will U, Meyer F, Manger T, Wanzar I. Endoscopic ultrasound-assisted rendezvous maneuver to achieve pancreatic duct drainage in obstructive chronic pancreatitis. Endoscopy. 2005;37(2):171–3.

    Article  CAS  PubMed  Google Scholar 

  13. Papachristou GI, Gleeson FC, Petersen BT, Levy MJ. Pancreatic endoscopic ultrasound-assisted rendezvous procedure to facilitate drainage of nondilated pancreatic ducts. Endoscopy. 2007;39(Suppl 1):E324–5.

    Article  PubMed  Google Scholar 

  14. Fujii LL, Topazian MD, Abu Dayyeh BK, et al. EUS-guided pancreatic duct intervention: outcomes of a single tertiary-care referral center experience. Gastrointest Endosc. 2013;78(6):854–64. e851

    Article  PubMed  Google Scholar 

  15. Park SH, de Bellis M, McHenry L, et al. Use of methylene blue to identify the minor papilla or its orifice in patients with pancreas divisum. Gastrointest Endosc. 2003;57(3):358–63.

    Article  PubMed  Google Scholar 

  16. Ohshima Y, Tsukamoto Y, Naitoh Y, et al. Function of the minor duodenal papilla in pancreas divisum as determined by duodenoscopy using indigo carmine dye and a pH sensor. Am J Gastroenterol. 1994;89(12):2188–91.

    CAS  PubMed  Google Scholar 

  17. Luo H, Zhao L, Leung J, et al. Routine pre-procedural rectal indometacin versus selective post-procedural rectal indometacin to prevent pancreatitis in patients undergoing endoscopic retrograde cholangiopancreatography: a multicentre, single-blinded, randomised controlled trial. Lancet. 2016;387(10035):2293–301.

    Article  CAS  PubMed  Google Scholar 

  18. Elmunzer BJ, Scheiman JM, Lehman GA, et al. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012;366(15):1414–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Dumonceau JM, Andriulli A, Elmunzer BJ, et al. Prophylaxis of post-ERCP pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) guideline – updated June 2014. Endoscopy. 2014;46(9):799–815.

    Article  PubMed  Google Scholar 

  20. Elmunzer BJ, Higgins PD, Saini SD, et al. Does rectal indomethacin eliminate the need for prophylactic pancreatic stent placement in patients undergoing high-risk ERCP? Post hoc efficacy and cost-benefit analyses using prospective clinical trial data. Am J Gastroenterol. 2013;108(3):410–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Petersen BT. Cannulation techniques: biliary and pancreatic. Tech Gastrointest Endosc. 2003;5(1):17–26.

    Article  Google Scholar 

  22. Benage D, McHenry R, Hawes RH, O’Connor KW, Lehman GA. Minor papilla cannulation and dorsal ductography in pancreas divisum. Gastrointest Endosc. 1990;36(6):553–7.

    Article  CAS  PubMed  Google Scholar 

  23. Devereaux BM, Lehman GA, Fein S, Phillips S, Fogel EL, Sherman S. Facilitation of pancreatic duct cannulation using a new synthetic porcine secretin. Am J Gastroenterol. 2002;97(9):2279–81.

    Article  CAS  PubMed  Google Scholar 

  24. Devereaux BM, Fein S, Purich E, et al. A new synthetic porcine secretin for facilitation of cannulation of the dorsal pancreatic duct at ERCP in patients with pancreas divisum: a multicenter, randomized, double-blind comparative study. Gastrointest Endosc. 2003;57(6):643–7.

    Article  PubMed  Google Scholar 

  25. Moffatt DC, Cote GA, Avula H, et al. Risk factors for ERCP-related complications in patients with pancreas divisum: a retrospective study. Gastrointest Endosc. 2011;73(5):963–70.

    Article  PubMed  Google Scholar 

  26. Lehman GA, Sherman S, Nisi R, Hawes RH. Pancreas divisum: results of minor papilla sphincterotomy. Gastrointest Endosc. 1993;39(1):1–8.

    Article  CAS  PubMed  Google Scholar 

  27. Coleman SD, Eisen GM, Troughton AB, Cotton PB. Endoscopic treatment in pancreas divisum. Am J Gastroenterol. 1994;89(8):1152–5.

    CAS  PubMed  Google Scholar 

  28. Kozarek RA, Ball TJ, Patterson DJ, Brandabur JJ, Raltz SL. Endoscopic approach to pancreas divisum. Dig Dis Sci. 1995;40(9):1974–81.

    Article  CAS  PubMed  Google Scholar 

  29. Gerke H, Byrne MF, Stiffler HL, et al. Outcome of endoscopic minor papillotomy in patients with symptomatic pancreas divisum. JOP J Pancreas. 2004;5(3):122–31.

    Google Scholar 

  30. Chacko LN, Chen YK, Shah RJ. Clinical outcomes and nonendoscopic interventions after minor papilla endotherapy in patients with symptomatic pancreas divisum. Gastrointest Endosc. 2008;68(4):667–73.

    Article  PubMed  Google Scholar 

  31. Borak GD, Romagnuolo J, Alsolaiman M, Holt EW, Cotton PB. Long-term clinical outcomes after endoscopic minor papilla therapy in symptomatic patients with pancreas divisum. Pancreas. 2009;38(8):903–6.

    Article  PubMed  Google Scholar 

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Correspondence to Bret T. Petersen .

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Larson, A., Petersen, B.T. (2018). Minor Papilla Cannulation and Endotherapy. In: Sridhar, S., Wu, G. (eds) Diagnostic and Therapeutic Procedures in Gastroenterology. Clinical Gastroenterology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-62993-3_28

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  • DOI: https://doi.org/10.1007/978-3-319-62993-3_28

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-62991-9

  • Online ISBN: 978-3-319-62993-3

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