By definition, mixed vitiligo (MV) is the association of a characteristic segmental involvement associated usually in a second step with the onset of bilateral vitiligo patches. The association of segmental vitiligo (SV) to vitiligo/nonsegmental vitiligo (vitiligo/NSV) suggests a continuum between the two subsets which were formerly opposed. A common mode of revelation is a segment resistant to phototherapy in a patient diagnosed previously as vitiligo/NSV. Halo nevi and leukotrichia at first consultation in segmental vitiligo are risk factors for the progression of SV to MV. In addition, this progression of SV to MV carries a stronger link if the segment is initially situated on the trunk. Combined somatic mosaicism and immune dysregulation may explain the continuum SV-vitiligo/NSV in the case of MV.
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