Abstract
EBM guidelines have many limitations in a field like vitiligo but can help to fight charlatanism and harmful interventions. Inflammation/autoimmunity are the major targets to stop disease progression. Combination therapies using systemic/topical antiinflammatory-immunosuppressant drugs with UVB therapy are the current mainstay approach for vitiligo. More targeted immunosuppressants such as Jak inhibitors are currently in clinical development Novel approaches should promote melanocyte survival and stability within the basal membrane zone of the epidermis.
Regenerative medicine is the next important development because of the exhaustion of spontaneous regeneration especially in acral locations.
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Taïeb, A., Picardo, M. (2019). Editor’s Synthesis and Perspectives. In: Picardo, M., Taïeb, A. (eds) Vitiligo. Springer, Cham. https://doi.org/10.1007/978-3-319-62960-5_46
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