Vitiligo pathogenesis still represents a puzzle whose pieces are not all at the same level of knowledge and interest among the scientist people. The most popular aspects currently considered include genetic, inflammatory, autoimmune, oxidative, and metabolic alterations, even if the individual contribution of each of these alterations is still unclear. The role of local environment, detachment process and emerging pathways needs renewed attention. These pieces of vitiligo puzzle represent a possible link between the most studied mechanisms and all three together are supporting each other.
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