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Vitiligo pp 277-283 | Cite as

Oxidative Stress and Intrinsic Defects

  • Mauro PicardoEmail author
  • Maria Lucia Dell’Anna
Chapter

Abstract

Overall, experimental data support intrinsic damage and a close link between oxidative stress and immune responses. For example, histological analysis of developing lesions shows NALP1 (NACHT, LRR, and PYD domain-containing protein 1), IL-1, and catalase expression; moreover, the expression levels of heme oxygenase 1 in plasma have been linked to the activity phase of the disease and to IL-2 levels. All of these factors are involved both in stress responses and triggering of innate immunity. In summary, genetic, experimental, and clinical studies have revealed important pathways in the pathogenesis of vitiligo and have identified targets for the development of new therapies.

Our unified view considers the intrinsic defect in melanocytes as the initial event. In this model, oxidative stress in the melanocytes leads to a local inflammatory response and the activation of innate immune processes, which, in subjects with a genetic predisposition to develop autoimmunity, generate melanocyte-specific cytotoxic immune responses.

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Cutaneous Physiopathology and CIRMSan Gallicano Dermatological Institute, IRCCSRomeItaly
  2. 2.Laboratory of Cutaneous PhysiopathologySan Gallicano Dermatological Institute IFORomeItaly

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