Abstract
Please check the hierarchy of the section headings and confirm if correct.
References
Schug TT, Janesick A, Blumberg B, Heindel JJ. Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol. 2011;127(3-5):204–15.
Polyzos SA, Kountouras J, Deretzi G, Zavos C, Mantzoros CS. The emerging role of endocrine disruptors in pathogenesis of insulin resistance: a concept implicating nonalcoholic fatty liver disease. Curr Mol Med. 2012;12:68–82.
Sharpe RM, Drake AJ. Bisphenol A and metabolic syndrome. Endocrinology. 2010;151:2404–7.
Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, et al. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr Rev. 2009;30(4):293–342.
Baillie-Hamilton PF. Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med. 2002;8:185–92.
Wardle J, Cooke L. The impact of obesity on psychological well-being. Best Pract Res Clin Endocrinol Metab. 2005;19:421–40.
Newbold RR, Jefferson WN, Padilla-Banks E. Long-term adverse effects of neonatal exposure to bisphenol A on the murine female reproductive tract. Reprod Toxicol. 2007a;24:253–8.
Newbold RR, Padilla-Banks E, Snyder RJ, Phillips TM, Jefferson WN. Developmental exposure to endocrine disruptors and the obesity epidemic. Reprod Toxicol. 2007b;23:290–6.
Thayer KA, Heindel JJ, Bucher JR, Gallo MA. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review. Environ Health Perspect. 2012;120:779–89.
Irigaray P, et al. Benzo[a]pyrene impairs β-adrenergic stimulation of adipose tissue lipolysis and causes weight gain in mice. A novel molecular mechanism of toxicity for a common food pollutant. FEBS J. 2006;273:1362–72.
Jerrett M, et al. Traffic-related air pollution and obesity formation in children: a longitudinal, multilevel analysis. Environ Health. 2014;13:49.
McConnell R, et al. Does near-roadway air pollution contribute to childhood obesity? Pediatr Obes. 2015;11:1–3. https://doi.org/10.1111/ijpo.12016.
Zheng Z, et al. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model. J Hepatol. 2013;58:148–54.
Vandenberg LN, Maffini MV, Wadia PR, Sonnenschein C, Rubin BS, Soto AM. Exposure to environmentally relevant doses of the xenoestrogen bisphenol-A alters development of the fetal mouse mammary gland. Endocrinology. 2007;148:116–27.
Chamorro-Garcia R, Sahu M, Abbey RJ, Laude J, Pham N, Blumberg B. Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice. Environ Health Perspect. 2013;121:359–66.
Masuno H, Iwanami J, Kidani T, Sakayama K, Honda K. Bisphenol A accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway. Toxicol Sci. 2005;84:319–27.
Mackay H, Patterson ZR, Khazall R, Patel S, Tsirlin D, Abizaid A. Organizational effects of perinatal exposure to bisphenol-A and diethylstilbestrol on arcuate nucleus circuitry controlling food intake and energy expenditure in male and female CD-1 mice. Endocrinology. 2013;154:1465–75.
Chao HR, Wang SL, Lee WJ, Wang YF, Papke O. Levels of polybrominated diphenyl ethers (PBDEs) in breast milk from central Taiwan and their relation to infant birth outcome and maternal menstruation effects. Environ Int. 2007;33:239–45.
Herbstman JB, Sjodin A, Apelberg BJ, Witter FR, Halden RU, Patterson DG, et al. Birth delivery mode modifies the associations between prenatal polychlorinated biphenyl (PCB) and polybrominated diphenyl ether (PBDE) and neonatal thyroid hormone levels. Environ Health Perspect. 2008;116:1376–82.
Legler J, Hamers T, van Eck van der Sluijs-van de Bor M, Schoeters G, van der Ven L, Eggesbo M et al. The OBELIX project: early life exposure to endocrine disruptors and obesity. Am J Clin Nutr. 2011;94:1933S–8S.
Patisaul HB, Roberts SC, Mabrey KA, McCaffrey KA, Gear RB, Braun J, et al. Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment. J Biochem Mol Toxicol. 2013;27:124–36.
Belcher SM, Cookman CJ, Patisaul HB, Stapleton HM. In vitro assessment of human nuclear hormone receptor activity and cytotoxicity of the flame retardant mixture FM 550 and its triarylphosphate and brominated components. Toxicol Lett. 2014;228:93–102.
Pillai HK, Fang F, Beglov D, Kozakov D, Vajda S, Stapleton HM, et al. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect. 2014;122:1225–32.
Bourez S, Van den D, Aelen C, Le Lay S, Poupaert J, Larondelle Y, Thome JP, et al. The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener. Toxicol Lett. 2013;216:40–6.
Elobeid MA, Brock DW, AllisonDB PMA, Ruden DM. Endocrine disruptors and obesity: an examination of selected persistent organic pollutants in the NHANES 1999–2002 data. Int J Environ Res Public Health. 2010;7:2988–3005.
Hao C, Cheng X, Xia H, Ma X. The endocrine disruptor mono-(2-ethylhexyl) phthalate promotes adipocyte differentiation and induces obesity in mice. Biosci Rep. 2012;32:619–29.
Hines EP, White SS, Stanko JP, Gibbs-Flournov EA, Lau C, Fenton SE. Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: low doses induce elevated serum leptin and insulin, and overweight in mid-life. Mol Cell Endocrinol. 2009;304:97–105.
Asher MI, Montefort S, Bjorksten B, Lai CKW, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet. 2006;368(9537):733–43.
WHO (World Health Organization). Asthma. Fact Sheet No. 307. 2006. Available http://www.who.int/mediacentre/factsheets/fs307/en/. Accessed 22 Oct 2006.
Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, Kerkhof M, Brunekreef B. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007;29(5):879–88.
Gauderman WJ, Avol E, Lurmann F, Kuenzli N, Gilliland F, Peters J, McConnell R. Childhood asthma and exposure to traffic and nitrogen dioxide. Epidemiology. 2005;16(6):737–43.
Haberg SE, Stigum H, Nystad W, Nafstad P. Effects of pre- and postnatal exposure to parental smoking on early childhood respiratory health. Am J Epidemiol. 2007;166(6):679–86.
McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, et al. Traffic, susceptibility, and childhood asthma. Environ Health Perspect. 2006;114:766–72.
Zmirou D, Gauvin S, Pin I, Momas I, Sahraoui F, Just J, et al. Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study. J Epidemiol Community Health. 2004;58(1):18–23.
Dodson RE, Levy JI, Spengler JD, Shine JP, Bennett DH. Influence of basements, garages, and common hallways on indoor residential volatile organic compound concentrations. Atmos Environ. 2008;42(7):1569–81.
Lorber M. Exposure of Americans to polybrominated diphenyl ethers. J Expo Sci Environ Epidemiol. 2008;18(1):2–19.
Rudel RA, Seryak LM, Brody JG. PCB-containing wood floor finish is a likely source of elevated PCBs in residents’ blood, household air and dust: a case study of exposure. Environ Health. 2008;7:2.
Zota AR, Rudel RA, Morello-Frosch RA, Brody JG. Elevated house dust and serum concentrations of PBDEs in California: unintended consequences of furniture flammability standards? Environ Sci Technol. 2008;42(21):8158–64.
Bornehag CG, Sundell J, Weschler CJ, Sigsgaard T, Lundgren B, Hasselgren M, et al. The association between asthma and allergic symptoms in children and phthalates in house dust: a nested case–control study. Environ Health Perspect. 2004;112:1393–7.
Blunt E. Diethylstilbesrol exposure: it’s still an issue. Holist Nurs Pract. 2004;18(4):187–91.
Schrager S, Potter BE. Diethylstilbestrol exposure. Am Fam Physician. 2004;69(10):2395–400.
Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–8.
Dolk H, Vrijheid M, Scott JES, Addor MC, Botting B, Vigan C, et al. Toward the effective surveillance of hypospadais. Environ Health Perspect. 2004;112(3):398–402.
Ledger WL, Bahathiq AOS. Historical background and functional anatomy. In: The fallopian tube in infertility and IVF practice. 1st ed. New York: Cambridge University Press; 2010. p. 1–7.
Brouwers MM, van der Zanden LFM, de Gier RPE, Barten EJ, Zielhuis GA, Feitz WFJ, et al. Hypospadias: risk factor patterns and different phenotypes. BJU Int. 2009;105:254–62.
Kurahashi N, Murakumo M, Kakizaki H, Nonomura K, Koyanagi T, Kasai S, et al. The estimated prevalence of hypospadias in Hokkaido, Japan. J Epidemiol. 2004;14(3):73–7.
Yoo JH. Differential diagnosis of hypospadias. J Korean Soc Pediatr Endocrinol. 2006;11(1):15–21.
Boisen KA, Kaleva M, Main KM, Virtanen HE, Haevisto A-M, Schmidt IM, et al. Difference in prevalence of congenital cryptorchidism in infant between two Nordic countries. Lancet. 2004;363:1264–9.
Preiksa RT, Zilaitiene B, Matulevicius V, Skakkebaek NE, Petersen JH, Jørgensen N, et al. Higher than expected prevalence of congenital cryptorchidism in Lithuania: a study of 1204 boys at birth and 1 year follow-up. Hum Reprod. 2005;20:1928–32.
Damgaard IN, Skakkebaek NE, Toppari J, Virtanen HE, Shen H, Schramm KW, et al. Persistent pesticides in human breast milk and cryptorchidism. Environ Health Perspect. 2006;114:1133–8.
Thorup J, Cortes D, Petersen BL. The incidence of bilateral cryptorchidism is increased and the fertility potential is reduced in sons born to mothers who have smoked during pregnancy. J Urol. 2006;176:734–7.
Fratric I, Zivkovic D, Vukmirovic S. Human exposure to endocrine disrupting chemicals as a prenatal risk factor for cryptorchidism. Paediatr Croat. 2015;59:19–24.
Anway MD, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors. Endocrinology. 2006;147:S43–9.
Mendiola J, Jorgensen N, Andersson A, Calafat A, Silva M, Redmon J, et al. Association between urinary metabolites of di(2-ethylhexyl) phtahalate and reproductive hormones in fertile men. Int J Androl. 2010;14:1–10.
Pan G, Hanoka T, Yoshimura M, Zhang S, Wang P, Tsukino H, et al. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross sectional study in China. Environ Health Perspect. 2006;114(1):1643–8.
Corton JC, Lapinskas PJ. Peroxisome proliferator-activated receptors: mediators of phthalate ester-induced effects in the male reproductive tract? Toxicol Sci. 2005;83(1):4–17.
Rozati R, Reddy PP, Reddanna P, Mujtaba R. Role of environmental estrogens in the deterioration of male factor fertility. Fertil Steril. 2002;78(6):1187–94.
Tan LF, Sun XZ, Li YN, Ji JM, Wang QL, Chen LS, et al. Effects of carbaryl production exposure on the sperm and semen quality of occupational male workers. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005;23:87–90.
Meeker JD, Ryan L, Barr DB, Herrick RF, Bennett DH, Bravo R, et al. The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality. Environ Health Perspect. 2004;112:1665–70.
Swan SH, Kruse RL, Liu F, Barr DB, Drobnis EZ, Redmon JB, et al. Semen quality in relation to biomarkers of pesticide exposure. Environ Health Perspect. 2003;111:1478–84.
Del-Mazo J, Brieno-Enriquez MA, Garcia-Lopez J, Lopez-Fernandez LA, De-Felici M. Endocrine disruptors, gene deregulation and male germ cell tumors. Int J Dev Biol. 2013;57(2-4):225–39.
Giannandrea F, Paoli D, Figa-Talamanca I, Lombardo F, Lenzi A, Gandini L. Effect of endogenous and exogenous hormones on testicular cancer: the epidemiological evidence. Int J Dev Biol. 2013;57(2-4):255–63.
Erickson RL. Persistent organochlorine pesticides and risk of testicular germ cell tumors. J Natl Cancer Inst. 2008;100(9):663–71.
LeCornet C, Fervers B, Oksbjerg Dalton S, Feychting M, Pukkala E, Tynes T, et al. Testicular germ cell tumours and parental occupational exposure to pesticides: a register-based case–control study in the Nordic countries (NORD-TEST study). Occup Environ Med. 2015;72(11):805–11.
Paoli D, Giannandrea F, Gallo M, Turci R, Cattaruzza MS, Lombardo F, et al. Exposure to polychlorinated biphenyls and hexachlorobenzene, semen quality and testicular cancer risk. J Endocrinol Investig. 2015;38(7):745–52.
Sweeney MF, Hasan N, Soto AM, Sonnenschein C. Environmental endocrine disruptors: effects on the human male reproductive system. Rev Endocr Metab Disord. 2016;16:341–57.
Cowin PA, Foster PMD, Risbridger GP. Endocrine disruption in the male. In: Gore AC, editor. Endrocrine-disrupting chemicals: from basic research to clinical practice. Totowa: Humana; 2007. p. 33–62.
Modugno F, Weissfeld JL, Trump DL, Zmuda JM, Shea P, Cauley JA, et al. Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk. Clin Cancer Res. 2001;7:3092–6.
Katzenwadel A, Wolf P. Androgen deprivation of prostate cancer: leading to a therapeutic dead end. Cancer Lett. 2015;367(1):12–7.
Alavanja MC, Samanic C, Dosemeci M, Lubin J, Tarone R, Lynch CF, et al. Use of agricultural pesticides and prostate cancer risk in the Agricultural Health Study cohort. Am J Epidemiol. 2003;157:800–14.
Mahajan R, Bonner MR, Hoppin JA, Alavanja MC. Phorate exposure and incidence of cancer in the agricultural health study. Environ Health Perspect. 2006;114:1205–9.
Song KH, Lee K, Choi HS. Endocrine disruptor bisphenol A induces orphan nuclear receptor Nur77 gene expression and steroidogenesis in mouse testicular Leydig cells. Endocrinology. 2002;143:2208–15.
Walsh DE, Dockery P, Doolan CM. Estrogenreceptor independent rapid non-genomic effects of environmental estrogens on [Ca2]i in human breast cancer cells. Mol Cell Endocrinol. 2005;230:23–30.
Charles LE, Loomis D, Shy CM, Newman B, Millikan R, Nylander-French LA, et al. Electromagnetic fields, polychlorinated biphenyls, and prostate cancer mortality in electric utility workers. Am J Epidemiol. 2003;157:683–91.
Prince MM, Ruder AM, Hein MJ, Waters MA, Whelan EA, Nilsen N, et al. Mortality and exposure response among 14,458 electrical capacitor manufacturing workers exposed to polychlorinated biphenyls (PCBs). Environ Health Perspect. 2006;114:1508–14.
Ritchie JM, Vial SL, Fuortes LJ, Guo H, Reedy VE, Smith EM. Organochlorines and risk of prostate cancer. J Occup Environ Med. 2003;45:692–702.
Kester MH, Bulduk S, van Toor H, Tibboel D, Meinl W, Glatt H, et al. Potent inhibition of estrogen sulfotransferase by hydroxylated metabolites of polyhalogenated aromatic hydrocarbons reveals alternative mechanism for estrogenic activity of endocrine disrupters. J Clin Endocrinol Metab. 2002;87:1142–50.
Benbrahim-Tallaa L, Liu J, Webber MM, Waalkes MP. Estrogen signaling and disruption of androgen metabolism in acquired androgen-independence during cadmium carcinogenesis in human prostate epithelial cells. Prostate. 2007a;67:135–45.
Davey JC, Bodwell JE, Gosse JA, Hamilton JW. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci. 2007;98:75–86.
Benbrahim-Tallaa L, Webber MM, Waalkes MP. Mechanisms of acquired androgen independence during arsenic-induced malignant transformation of human prostate epithelial cells. Environ Health Perspect. 2007b;115:243–7.
Costa EM, Spritzer PM, Hohl A, Bachega TA. Effects of endocrine disruptors in the development of the female reproductive tract. Arq Bras Endocrinol Metabol. 2014;58:153–61.
Ozen S, Darcan S. Effects of environmental endocrine disruptors on pubertal development. J Clin Res Pediatr Endocrinol. 2011;3:1–6.
Mlynarcikova A, Nagyova E, Fickova M, Scsukova S. Effects of selected endocrine disruptors on meiotic maturation, cumulus expansion, synthesis of hyaluronan and progesterone by porcine oocyte-cumulus complexes. Toxicol In Vitro. 2009;23:371–7.
Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, et al. Position statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome. An Androgen Excess Society guideline. J Clin Endocrinol Metab. 2006;91:4237–45.
Legro RS, Azziz R, Giudice L. A twenty-first century research agenda for polycystic ovary syndrome. Best Pract Res Clin Endocrinol Metab. 2006;20:331–6.
Franks S, Mason H, Willis D. Follicular dynamics in the polycystic ovary syndrome. Mol Cell Endocrinol. 2000;163:49–52.
Yildiz BO, Knochenhauer ES, Azziz R. Impact of obesity on the risk for polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93:162–8.
Kandaraki E, Chatzigeorgiou A, Livadas S, Palioura E, Economou F, Koutsilieris M, et al. Endocrine disruptors and polycystic ovary syndrome (PCOS): elevated serum levels of bisphenol A in women with PCOS. J Clin Endocrinol Metab. 2011;96:480–4.
Miao M, Yuan W, Yang F, Liang H, Zhou Z, Li R, et al. Associations between Bisphenol A exposure and reproductive hormones among female workers. Int J Environ Res Public Health. 2015;12:13240–50.
Eichenlaub-Ritter U, Vogt E, Cukurcam S, Sun F, Pacchierotti F, Parry J. Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy. Mutat Res. 2008;651:82–92.
Li Y, Zhang W, Liu J, Wang W, Li H, Zhu J, et al. Prepubertal bisphenol A exposure interferes with ovarian follicle development and its relevant gene expression. Reprod Toxicol. 2014;44:33–40.
Rivera OE, Varayoud J, RodrÃguez HA, Muñoz-de-Toro M, Luque EH. Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb. Reprod Toxicol. 2011;32:304–12.
Susiarjo M, Hassold TJ, Freeman E, Hunt PA. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. PLoS Genet. 2007;3:e5.
Zhou W, Liu J, Liao L, Han S, Liu J. Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells. Mol Cell Endocrinol. 2008;283(1–2):12–8.
Fact Sheet. The patient education website of the American Society for reproductive medicine. 2012. www.ReproductiveFacts.org.
Berkowitz G. Limitations of a case–control study on bisphenol A (BPA) serum levels and recurrent miscarriage. Hum Reprod. 2006;21:565–6.
Fenichel P, Dechaux H, Harthe C, Gal J, Ferrari P, Pacini P, et al. Unconjugated bisphenol A cord blood levels in boys with descended or undescended testes. Hum Reprod. 2012;27:983–90.
Sugiura-Ogasawara M, Ozaki Y, Sonta S, Makino T, Suzumori K. Exposure to bisphenol A is associated with recurrent miscarriage. Hum Reprod. 2005;20:2325–9.
Caserta D, Di Segni N, Mallozzi M, Giovanale V, Mantovani A, Marci R, et al. Bisphenol A and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies. Reprod Biol Endocrinol. 2014;12:37.
Peretz J, Vrooman L, Ricke WA, Hunt PA, Ehrlich S, Hauser R, et al. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect. 2014;122:775–86.
Wallach EE, Vlahos NF. Uterine myomas: an overview of development, clinical features, and management. Obstet Gynecol. 2004;104:393–406.
Hunter DS, Hodges LC, Eagon PK, Vonier PM, Fuchs-Young R, Bergerson JS, et al. Influence of exogenous estrogen receptor ligands on uterine leiomyoma: evidence from an in vitro/in vivo animal model for uterine fibroids. Environ Health Perspect. 2000;108(Suppl 5):829–34.
Hiroi H, Tsutsumi O, Takeuchi T, Momoeda M, Ikezuki Y, Okamura A, et al. Differences in serum bisphenol A concentrations in premenopausal normal women and women with endometrial hyperplasia. Endocr J. 2004;51:595–600.
Sinha P, Kuruba N. Premature ovarian failure. J Obstet Gynaecol. 2007;27:16–9.
McNatty KP, Reader K, Smith P, Heath DA, Juengel JL. Control of ovarian follicular development to the go-nadotrophin-dependent phase: a 2006 perspective. Soc Reprod Fertil Suppl. 2007;64:55–68.
Kaipia A, Hsueh AJ. Regulation of ovarian follicle atresia. Annu Rev Physiol. 1997;59:349–63.
Kirigaya A, Kim H, Hayashi S, Chambon P, Watanabe H, Lguchi T, et al. Involvement of estrogen receptor beta in the induction of polyovular follicles in mouse ovaries exposed neonatally to diethylstilbestrol. Zool Sci. 2009;26(10):704–12.
Newbold RR, Jefferson WN, Padilla-Banks E. Prenatal exposure to bisphenol A at environmentally relevant doses adversely affects the murine female reproductive tract later in life. Environ Health Perspect. 2009;117(6):879–85.
Brieno-EnrÃquez MA, Reig-Viader R, Cabero L, Toran N, MartÃnez F, Roig I, et al. Gene expression is altered after bisphenol A exposure in human fetal oocytes in vitro. Mol Hum Reprod. 2012;18(4):171–83.
Hoyer PB, Devine PJ, Hu X, Thompson KE, Sipes IG. Ovarian toxicity of 4-vinylcyclohexene diepoxide: a mechanistic model. Toxicol Pathol. 2001;29(1):91–9.
Kappeler CJ, Hoyer PB. 4-vinylcyclohexene diepoxide: a model chemical for ovotoxicity. Syst Biol Reprod Med. 2012;58(1):57–62.
Gaido KW, Maness SC, McDonnell DP, Dehal SS, Kupfer D, Safe S. Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol. 2000;58(4):852–8.
Colborn T, Demanoski D, Myers JP. Our stolen future. New York: Penguin; 1997.
Markey CM, Rubin BS, Soto AM, Sonnenschein C. Endocrine disruptors: from wingspread to environmental developmental biology. J Steroid Biochem Mol Biol. 2002;83:235–44.
Richter CA, Birnbaum LS, Farabollini F, Newbold RR, Rubin BS, Talsness CE, et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol. 2007;24:199–224.
Zalko D, Soto AM, Dolo L, Dorio C, Rathahao E, Debrauwer L, et al. Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. Environ Health Perspect. 2003;111:309–19.
Munoz-de-Toro M, Markey CM, Wadia PR, Luque EH, Rubin BS, Sonnenschein C, et al. Perinatal exposure to bisphenol-A alters peri-pubertal mammary gland development in mice. Endocrinology. 2005;146:4138–47.
Murray TJ, Maffini MV, Ucci AA, Sonnenschein C, Soto AM. Induction of mammary gland ductal hyperplasia and carcinoma in situ following fetal bisphenol A exposure. Reprod Toxicol. 2007;23:383–90.
Durando M, Kass L, Piva J, Sonnenschein C, Soto AM, Luque EH, et al. Prenatal bisphenol A exposure induces preneoplastic lesions in the mammary gland in Wistar rats. Environ Health Perspect. 2007;115:80–6.
Brown NM, Manzolillo PA, Zhang JX, Wang J, Lamartiniere CA. Prenatal TCDD and predisposition to mammary cancer in the rat. Carcinogenesis. 1998;19:1623–9.
Fenton SE. Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences. Endocrinology. 2006;147:S18–24.
Olive DL, Schwartz LB. Endometriosis. N Engl J Med. 1993;328:1759–69.
Igarashi T, Osuga U, Tsutsumi O, Momoeda M, Ando K, Matsumi H, et al. Expression of Ah receptor and dioxin-related genes in human uterine endometrium in women with or without endometriosis. Endocr J. 1999;46:765–72.
Kuchenhoff A, Seliger G, Klonisch T, Tscheudschilsuren G, Kaltwasser P, Seliger E, et al. Arylhydrocarbon receptor expression in the human endometrium. Fertil Steril. 1999;71:354–60.
Rier S, Foster WG. Environmental dioxins and endometriosis. Toxicol Sci. 2002;70:161–70.
Porpora MG, Ingelido AM, di Domenico A, Ferro A, Crobu M, Pallante D, et al. Increased levels of polychlorobiphenyls in Italian women with endometriosis. Chemosphere. 2006;63:1361–7.
Bruner-Tran KL, Osteen KG. Dioxin-like PCBs and endometriosis. Syst Biol Reprod Med. 2010;56(2):132–46.
Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, et al. Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 2008;90:911–40.
Ibanez L, Ferrer A, Marcos MV. Early puberty: rapid progression and reduced final height in girls with low birth weight. Paediatrics. 2000;106:1–3.
Chittwar SS, Ammini AC. Precocious puberty in girls. Indian J Endocrinol Metab. 2012;16:S188–91.
Neely EK, Crossen SS. Precocious puberty. Curr Opin Obstet Gynecol. 2014;26:332–8.
Kotwal N, Yanamandra U, Menon AS, Nair V. Central precocious puberty due to hypothalamic hamartoma in a six-month-old infant girl. Indian J Endocrinol Metab. 2012;16:627–30.
Mogensen SS, Aksglaede L, Mouritsen A, Sorensen K, Main KM, Gideon P, et al. Pathological and incidental findings on brain MRI in a single center study of 229 consecutive girls with early or precocious puberty. PLoS One. 2012;7:e29829.
Trivin C, Couto-Silva AC, Sainte-Rose C, Chemaitilly W, Kalifa C, Doz F, et al. Presentation and evolution of organic central precocious puberty according to the type of CNS lesion. Clin Endocrinol. 2006;65:239–45.
Blanck HM, Marcus M, Hertzberg V, Tolbert PE, Rubin C, Henderson AK, et al. Determinants of polybrominated biphenyl serum decay among women in the Michigan PBB cohort. Environ Health Perspect. 2000a;108:147–52.
Blanck HM, Marcus M, Tolbert PE, Rubin C, Henderson AK, Hertzberg VS, et al. Age at menarche and tanner stage in girls exposed in utero and postnatally to polybrominated biphenyl. Epidemiology. 2000b;11:641–7.
Gladen BC, Ragan NB, Rogan WJ. Pubertal growth and development and prenatal and lactational exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene. J Pediatr. 2000;136:490–6.
Wade MG, Desaulniers D, Leingartner K, Foster WG. Interaction between endosulfan and dieldrin on estrogen-mediated processes in vitro and in vivo. Reprod Toxicol. 1997;11:791–8.
Denham M, Schell LM, Deane G, Gallo MV, Ravenscroft J, DeCaprio AP, Task Force on the Environment, et al. Relationship of lead, mercury, mirex, dichlorodiphenyldichloroethylene, hexachlorobenzene, and polychlorinated biphenyls to timing of menarche among Akwesasne Mohawk girls. Pediatrics. 2005;115:127–34.
Yang CY, Yu ML, Guo HR, Lai TJ, Hsu CC, Lambert G, et al. The endocrine and reproductive function of the female Yucheng adolescents prenatally exposed to PCBs/PCDFs. Chemosphere. 2005;61:355–60.
Den Hond E, Roels HA, Hoppenbrouwers K, Nawrot T, Thijs L, Vandermeulen C, et al. Sexual maturation in relation to polychlorinated aromatic hydrocarbons: Sharpe and Skakkebaek’s hypothesis revisited. Environ Health Perspect. 2002;110:771–6.
Colon I, Caro D, Bourdony CJ, Rosario O. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect. 2000;108:895–900.
Fernández M, Bianchi M, Lux-Lantos V, Libertun C. Neonatal exposure to bisphenol A alters reproductive parameters and gonadotropin releasing hormone signaling in female rats. Environ Health Perspect. 2009;117(5):757–62.
Selevan SG, Rice DC, Hogan KA, Euling SY, Pfahles-Hutchens A, Bethel J. Blood lead concentration and delayed puberty in girls. N Engl J Med. 2003;348:1527–36.
Wu T, Buck GM, Mendola P. Blood lead levels and sexual maturation in US girls: the third National Health and Nutrition Examination Survey, 1988–1994. Environ Health Perpect. 2003;111:737–41.
Auso E, Lavado-Autric R, Cuevas E, Del Rey FE, Morreale DE, Berbel P. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology. 2004;145:4037–47.
Berbel P, Mestre JL, Santamaria A, Palazon I, Franco A, Graells M, et al. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid. 2009;19:511–9.
Boas M, Feldt-Rasmussen U, Main KM. Thyroid effects of endocrine disrupting chemicals. Mol Cell Endocrinol. 2012;355:240–8.
Howdeshell KL. A model of the development of the brain as a construct of the thyroid system. Environ Health Perspect. 2002;110(3):337–48.
Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid. 1998;8:827–56.
Gauger KJ, Kato Y, Haraguchi K, Lehmler HJ, Robertson LW, Bansal R, et al. Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors. Environ Health Perspect. 2004;112:516–23.
Martin L, Klaassen CD. Differential effects of polychlorinated biphenyl congeners on serum thyroid hormone levels in rats. Toxicol Sci. 2010;117:36–44.
Pavuk M, Schecter AJ, Akhtar FZ, et al. Serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) levels and thyroid function in Air Force veterans of the Vietnam War. Ann Epidemiol. 2003;13:335–43.
Baccarelli A, Giacomini SM, Corbetta C, et al. Neonatal thyroid function in Seveso 25 years after maternal exposure to dioxin. PLoS Med. 2008;5:e161.
Li F, Xie Q, Li X, Li N, Chi P, Chen J, et al. Hormone activity of hydroxylated polybrominated diphenyl ethers on human thyroid receptor-beta: in vitro and in silico investigations. Environ Health Perspect. 2010;118:602–6.
Meerts IA, van Zanden JJ, Luijks EA, Leeuwen-Bol I, Marsh G, Jakobsson E. Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro. Toxicol Sci. 2000;56:95–104.
Fini JB, Le MS, Turque N, Palmier K, Zalko D, Cravedi JP, et al. An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. Environ Sci Technol. 2007;41:5908–14.
Jagnytsch O, Opitz R, Lutz I, Kloas W. Effects of tetrabromobisphenol a on larval development and thyroid hormone-regulated biomarkers of the amphibian Xenopus laevis. Environ Res. 2006;101:340–8.
Hallgren S, Sinjari T, Hakansson H, Darnerud PO. Effects of polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) on thyroid hormone and vitamin A levels in rats and mice. Arch Toxicol. 2001;75:200–8.
Richardson VM, Staskal DF, Ross DG, Diliberto JJ, DeVito MJ, Birnbaum LS. Possible mechanisms of thyroid hormone disruption in mice by BDE 47, a major polybrominated diphenyl ether congener. Toxicol Appl Pharmacol. 2008;226:244–50.
Zhou LX, Dehal SS, Kupfer D, Morrell S, McKenzie BA, Eccleston ED Jr, et al. Cytochrome P450 catalyzed covalent binding of methoxychlor to rat hepatic, microsomal iodothyronine 50-monodeiodinase, type I: does exposure to methoxychlor disrupt thyroid hormone metabolism? Arch Biochem Biophys. 1995;322:390–4.
Olsen GW, Zobel LR. Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers. Int Arch Occup Environ Health. 2007;81:231–46.
Chang SC, Thibodeaux JR, Eastvold ML, Ehresman DJ, Bjork JA, Froehlich JW, et al. Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS). Toxicology. 2008;36:330–9.
Yu WG, Liu W, Jin YH. Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism. Environ Toxicol Chem. 2009;28:990–6.
Huang PC, Kuo PL, Guo YL, Liao PC, Lee CC. Associations between urinary phthalate monoesters and thyroid hormones in pregnant women. Hum Reprod. 2007;22:2715–22.
Freitas J, Cano P, Craig-Veit C, Goodson ML, David FJ, Murk AJ. Detection of thyroid hormone receptor disruptors by a novel stable in vitro reporter gene assay. Toxicol In Vitro. 2011;25:257–66.
Sun W, Ban J-B, Zhang N, Zu Y-K, Sun W-X. Perinatal exposure to di-(2-ethylhexyl)-phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environ Toxicol. 2014;29(5):596–603.
Hofmann PJ, Schomburg L, Kohrle J. Interference of endocrine disrupters with thyroid hormone receptor-dependent transactivation. Toxicol Sci. 2009;110:125–37.
Zoeller RT, Bansal R, Parris C. Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogran in expression in the developing rat brain. Endocrinology. 2005;146:607–12.
Dundar B, Oktem F, Arslan MK, et al. The effect of long-term low-dose lead exposure on thyroid function in adolescents. Environ Res. 2006;101:140–5.
Rodier PM. Developing brain as a target of toxicity. Environ Health Perspect. 1995;103(6):73–6.
Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(Suppl 3):511–33.
Andersen HR, Nielsen JB, Grandjean P. Toxicologic evidence of developmental neurotoxicity of environmental chemicals. Toxicology. 2000;144:121–7.
Ginsberg G, Hattis D, Sonawane B. Incorporating pharmacokinetic differences between children and adults in assessing children’s risks to environmental toxicants. Toxicol Appl Pharmacol. 2004;198:164–83.
National Research Council. Pesticides in the diets of infants and children. Washington: National Academy; 1993.
Rutter M. Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatr. 2005;94:2–15.
Landrigan PJ, Schechter CB, Lipton JM, Fahs MC, Schwartz J. Environmental pollutants and disease in American children: estimates of morbidity, mortality, and costs for lead poisoning, asthma, cancer, and developmental disabilities. Environ Health Perspect. 2002;110:721–08.
Mendola P, Selevan SG, Gutter S, Rice D. Environmental factors associated with a spectrum of neurodevelopmental deficits. Ment Retard Dev Disabil Res Rev. 2002;8:188–97.
National Research Council. Scientific frontiers in developmental toxicology and risk assessment. Washington: National Academy; 2000.
Trasande L, Landrigan PJ, Schechter C. Public health and economic consequences of methyl mercury toxicity to the developing brain. Environ Health Perspect. 2005;113:590–6.
Schantz SL, Widholm JJ, Rice DC. Effects of PCB exposure on neuropsychological function in children. Environ Health Perspect. 2003;111(3):357–576.
Jacobson LJ, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr. 2003;143(6):780–8.
Vreugdenhil HJ, Mulder PG, Emmen HH, Weisglas-Kuperus N. Effects of perinatal exposure to PCBs on neuropsychological functions in the Rotterdam cohort at 9 years of age. Neuropsychology. 2004;18(1):185–93.
Guo YL, Lambert GH, Hsu CC, Hsu MM. Yucheng: health effects of prenatal exposure to polychlorinated biphenyls and dibenzofurans. Int Arch Occup Environ Health. 2004;77(3):153–8.
Edwards SC, Jedrychowski W, Butscher M, Camann D, Kieltyka A, Mroz E, et al. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and children’s intelligence at 5 years of age in a prospective cohort study in Poland. Environ Health Perspect. 2010;118(9):1326–31.
Perera FP, Rauh V, Whyatt RM, Tsai WY, Tang D, Diaz D, et al. Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children. Environ Health Perspect. 2006;114(8):1287–92.
Takeda K, Tsukue N, Yoshida S. Endocrine-disrupting activity of chemicals in diesel exhaust and diesel exhaust particles. Environ Sci. 2004;11(1):33–45.
Yokota S, Mizuo K, Moriya N, Oshio S, Sugawara I, Takeda K. Effect of prenatal exposure to diesel exhaust on dopaminergic system in mice. Neurosci Lett. 2009;449(1):38–41.
Perera F, Herbstman J. Prenatal environmental exposures, epigenetics, and disease. Reprod Toxicol. 2011;31(3):363373.
Engel SM, Zhu C, Berkowitz GS, Calafat AM, Silva MJ, Miodovnik A. Prenatal phthalate exposure and performance on the Neonatal Behavioral Assessment Scale in a multiethnic birth cohort. Neurotoxicology. 2009;30(4):522–8.
Miodovnik A, Engel SM, Zhu C, Ye X, Soorya LV, Silva MJ, et al. Endocrine disruptors and childhood social impairment. Neurotoxicology. 2011;32(2):261–7.
Swan SH, Liu F, Hines M, Kruse RL, Wang C, Redmon JB, et al. Prenatal phthalate exposure and reduced masculine play in boys. Int J Androl. 2010;33(2):259–69.
Yolton K, Xu Y, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicol Teratol. 2011;33(5):558–66.
Perera F, Vishnevetsky J, Herbstman JB, Calafat AM, Xiong W, Rauh V, et al. Prenatal bisphenol A exposure and child behavior in an inner-city cohort. Environ Health Perspect. 2012;120(8):1190–4.
Jones DC, Miller GW. The effects of environmental neurotoxicants on the dopaminergic system: a possible role in drug addiction. Biochem Pharmacol. 2008;76(5):569–81.
Narita M, Mitagawa K, Mizuo K, Yoshida T, Sizuki T. Prenatal and neonatal exposure to low-dose of bisphenol-A enhance the morphine-induced hyperlocomotion and rewarding effect. Neurosci Lett. 2006;402(3):249–52.
Rauh V, Arunajadai S, Horton M, Perera F, Hoepner L, Barr DB, et al. Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ Health Perspect. 2011;119(8):1196–201.
Rauh VA, Perera FP, Horton MK, Whyatt RM, Bansal R, Hao X, et al. Brain anomalies in children exposed prenatally to a common organophosphate pesticide. Proc Natl Acad Sci U S A. 2012;109(20):7871–6.
Bigler ED, Mortensen S, Neeley ES, Ozonoff S, Krasny L, Johnson M, et al. Superior temporal gyrus, language function, and autism. Dev Neuropsychol. 2007;31(2):217–38.
Elliott R, Deakin B. Role of the orbitofrontal cortex in reinforcement processing and inhibitory control: evidence from functional magnetic resonance imaging studies in healthy human subjects. Int Rev Neurobiol. 2005;65:89–116.
Forbes CE, Grafman J. The role of the human prefrontal cortex in social cognition and moral judgment. Annu Rev Neurosci. 2010;33:299–324.
Shelton JF, Hertz-Picciotto I, Pessah IN. Tipping the balance of autism risk: potential mechanisms linking pesticides and autism. Environ Health Perspect. 2012;120(7):944–51.
Ohtani-Kaneko R, Tazawa H, Yokosuka M, Yoshida M, Satoh M, Watanabe C. Suppressive effects of cadmium on neurons and affected proteins in cultured developing cortical cells. Toxicology. 2008;253(1-3):110–6.
Hines M. Prenatal testosterone and gender-related behaviour. Eur J Endocrinol. 2006;155(1):S115–21.
Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet. 2007;8(4):253–62.
Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci. 2006;31:89–97.
Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002;3:662–73.
Talbert PB, Henikoff S. Spreading of silent chromatin: inaction at a distance. Nat Rev Genet. 2006;7:793–803.
Chan TL, Yuen ST, Kong CK, Chan YW, Cahn AS, Ng WF, et al. Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nat Genet. 2006;38:1178–83.
Suter CM, Martin DI, Ward RL. Germline epimutation of MLH1 in individuals with multiple cancers. Nat Genet. 2004;36:497–501.
Anway MD, Cupp AS, Uzumcu M, Skinner MK. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 2005;308:1466–9.
Pembrey ME, Bygren LO, Kaati G, Edvinsson S, Northstone K, Sjöström M, Golding J. Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet. 2006;14:159–66.
Rakyan VK, Chong S, Champ ME, Cuthbert PC, Morgan HD, Luu KV, et al. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A. 2003;100:2538–43.
Andersen HR, Schmidt IM, Grandjean P, Jensen TK, Budtz-Jorgensen E, Kjaerstad MB, et al. Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environ Health Perspect. 2008;116(4):566–72.
Dolinoy DC, Huang D, Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A- induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A. 2007;104(32):13056–61.
Novikova SI, He F, Bai J, Cutrufello NJ, Lidow MS, Undieh AS. Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring. PLoS One. 2008;3(4):e1919.
Perera F, Tang WY, Herbstman J, Tang D, Levin L, Miller R, et al. Relation of DNA methylation of 5’-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS One. 2009;4(2):e4488.
Yaoi T, Itoh K, Nakamura K, Ogi H, Fujiwara Y, Fushiki S. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun. 2008;376(3):563–7.
Andre SM, Markowski VP. Learning deficits expressed as delayed extinction of a conditioned running response following perinatal exposure to vinclozolin. Neurotoxicol Teratol. 2006;28(4):482–8.
Crews D, Gore AC, Hsu TS, Dangleben NL, Spinetta M, Schallert T, et al. Transgenerational epigenetic imprints on mate preference. Proc Natl Acad Sci U S A. 2007;104(14):5942–6.
Ottinger MA, Lavoie E, Thompson N, Barton A, Whitehouse K, Barton M, et al. Neuroendocrine and behavioral effects of embryonic exposure to endocrine disrupting chemicals in birds. Brain Res Rev. 2008;57(2):376–85.
Skinner MK, Anway MD, Savenkova MI, Gore AC, Crews D. Transgenerational epigenetic programming of the brain transcriptome and anxiety behavior. PLoS One. 2008;3(11):e3745.
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Jayshree, A., Vasudevan, N. (2018). Health Consequences Due to Prenatal Endocrine-Disrupting Chemical Exposure. In: Capello, F., Gaddi, A. (eds) Clinical Handbook of Air Pollution-Related Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-62731-1_22
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