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Mesothelioma and Thymic Tumors

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Abstract

This chapter will discuss the workup and management of mesothelioma and thymic tumors, with an emphasis on external beam radiotherapy technique and published evidence.

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References

  • Allen AM, Czerminska M, Janne PA, et al. Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys. 2006;65(3):640–5.

    Article  Google Scholar 

  • Allen AM, Schoenfield MS, Hacker F, et al. Restricted field IMRT dramatically enhances IMRT planning for mesothelioma. Int J Radiat Oncol Biol Phys. 2007a;69(5):1587–92.

    Article  Google Scholar 

  • Allen AM, Den R, Wong JS, et al. Influence of radiotherapy technique and dose on patterns of failure for mesothelioma patients after extrapleural pneumonectomy. Int J Radiat Oncol Biol Phys. 2007b;68(5):1366–74.

    Article  Google Scholar 

  • Boutin C, Rey F, Viallat R, et al. Prevention of malignant seeding after invasive diagnostic procedures in patients with pleural mesothelioma. A randomized trial of local radiotherapy. Chest. 1995;108(3):754–8.

    Article  CAS  Google Scholar 

  • Cao C, Tian D, Park J, et al. A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma. Lung Cancer. 2014;83(2):240–5.

    Article  Google Scholar 

  • Clive A, Taylor H, Dobson L, et al. Prophylactic radiotherapy for the prevention of procedure-tract metastases after surgical and large-bore pleural procedures in malignant pleural mesothelioma (SMART): a multicenter, open-label, phase 3, randomized controlled trial. Lancet Oncol. 2016;17(8):1094–104.

    Article  Google Scholar 

  • Curran WJ Jr, Kornstein MJ, Brooks JJ, et al. Invasive thymoma: the role of mediastinal irradiation following complete or incomplete surgical resection. J Clin Oncol. 1988;6:1722–7.

    Article  Google Scholar 

  • Flores R, Krug L, Rosenzweig K, et al. Induction chemotherapy, extrapleural pneumonectomy, and postoperative high-dose radiotherapy for locally advanced malignant pleural mesothelioma: a phase II trial. J Thorac Oncol. 2006;1:289–95.

    Article  Google Scholar 

  • Flores R, Pass H, Seshan V, et al. Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. J Thorac Cardiovasc Surg. 2008;135(3):620–6.

    Article  Google Scholar 

  • Forquer JA, Rong N, Fakiris AJ, et al. Postoperative radiotherapy after surgical resection of thymoma: differing roles in localized and regional disease. Int J Radiat Oncol Biol Phys. 2010;76(2):440–5.

    Article  Google Scholar 

  • Gupta V, Mychalczak B, Krug L, et al. Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma. Int J Radiat Oncol Biol Phys. 2005;63(4):1045–52.

    Article  Google Scholar 

  • Kim E, Putnam J, Komaki R, et al. Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report. Lung Cancer. 2004;44:369–79.

    Article  Google Scholar 

  • Komaki R, Travis EL, Cox JD. The lung and thymus. In: Cox JD, Ang KK, editors. Radiation oncology: rationale, technique, results. 8th ed. St. Louis: Mosby; 2003. p. 399–427.

    Google Scholar 

  • Kondo K, Monden Y. Therapy for thymic epithelial tumors: a clinical study of 1,320 patients from Japan. Ann Thorac Surg. 2003;76(3):878–84.

    Article  Google Scholar 

  • Korst R, Kansler A, Christos P, et al. Adjuvant radiotherapy for thymic epithelial tumors: a systematic review and meta-analysis. Ann Thorac Surg. 2009;87(5):1641–7.

    Article  Google Scholar 

  • Krayenbuhl J, OErtel S, Davis JB, et al. Combined photon and electron three-dimensional conformal versus intensity-modulated radiotherapy with integrated boost for adjuvant treatment of malignant pleural mesothelioma after pleuropneumectomy. Int J Radiat Oncol Biol Phys. 2007;69(5):1593–9.

    Article  Google Scholar 

  • Lim Y, Kim H, Wu HG. Role of postoperative radiotherapy in nonlocalized thymoma: propensity-matched analysis of surveillance, epidemiology and end results database. J Thorac Oncol. 2015;10(9):1357–63.

    Article  Google Scholar 

  • Loehrer PJ, Chen M, Kim K, et al. Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma: an intergroup trial. J ClinOncol. 1997;15(9):3093–9.

    Article  CAS  Google Scholar 

  • Masaoka A, Monden Y, Nakahara K, et al. Follow-up study of thymomas with special reference to their clinical stages. Cancer. 1981;48:2485.

    Article  CAS  Google Scholar 

  • Miles EF, Larrier NA, Kelsey CR, et al. Intensity modulated radiotherapy for restricted mesothelioma: the Duke experience. Int J Radiat Oncol Biol Phys. 2008;71(4):1143–50.

    Article  Google Scholar 

  • Mornex F. Radiotherapy and chemotherapy for invasive thymomas: a multicentric retrospective review of 90 cases. Int J Radiat Oncol Biol Phys. 1995;2:651–9.

    Article  Google Scholar 

  • O’Rourke N, Garcia JC, Paul J, et al. A randomized controlled trial of intervention site radiotherapy in malignant pleural mesothelioma. Radiother Oncol. 2007;84(1):18–22.

    Article  Google Scholar 

  • Omasa M, Date H, Sozu T, et al. Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: the Japanese Association for Research on the Thymus Database Study. Cancer. 2015;121(7):1008–16.

    Article  Google Scholar 

  • Rice DC, Stevens CW, Correa AM, et al. Outcomes after extrapleural pneumonectomy and intensity-modulated radiation therapy for malignant pleural mesothelioma. Ann Thorac Surg. 2007;84(5):1685–92.

    Article  Google Scholar 

  • Rimmer A, Zauderer M, Gomez D, et al. Phase II study of hemithoracic intensity-modulated pleural radiation (IMPRINT) as part of lung-sparing multimodality therapy in patients with malignant pleural mesothelioma. J Clin Oncol. 2016;34(23):2761–8.

    Article  Google Scholar 

  • Rusch VW, Rosenzweig K, Venkatraman E, et al. A phase II trial of surgical resection and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2001;122:788–95.

    Article  CAS  Google Scholar 

  • Sterzing F, Sroka-Perez G, Schubert K, et al. Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: helical tomotherapy compared with step and shoot IMRT. Radiother Oncol. 2008;86(2):251–7.

    Article  Google Scholar 

  • Treasure T, Lang-Lazdunski L, Waller D, et al. Extra-pleural pneumonectomy vs no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the mesothelioma and radical surgery (MARS) randomized feasibility study. Lancet Oncol. 2011;12(8):763–72.

    Article  Google Scholar 

  • Utsumi T, Shiono H, Kadota Y, et al. Postoperative radiation therapy after complete resection of thymoma has little impact on survival. Cancer. 2009;115(23):5413–20.

    Article  Google Scholar 

  • Van Schil P, Baas P, Gaafar R, et al. Trimodality therapy for malignant pleural mesothelioma: results from an EORTC phase II multicenter trial. Eur Respir J. 2010;36(6):1362–9.

    Article  Google Scholar 

  • Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003;21:2636–44.

    Article  CAS  Google Scholar 

  • Wright CD, Choi NC. Wain JC, et al induction chemoradiotherapy followed by resection for locally advanced Masaoka stage III and IVA thymic tumors. Ann Thorac Surg. 2008;85(2):385–9.

    Article  Google Scholar 

  • Zalcman G, Mazieres J, Margery J, et al. Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomized, controlled, open-label, phase 3 trial. Lancet. 2016;387(10026):1405–14.

    Article  CAS  Google Scholar 

  • Zhu G, He S, Fu X, Jiang G, Liu T. Radiotherapy and prognostic factors for thymoma: a retrospective study of 175 patients. Int J Radiat Oncol Biol Phys. 2004;60(4):1113–9. doi:10.1016/j.ijrobp.2004.05.013.

    Article  Google Scholar 

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Acknowledgment

We thank Fred Y. Wu MD, PhD, Brian Lee MD, PhD, and Joycelyn L. Speight MD, PhD for their work on the prior edition of this chapter.

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA

    Michael Wahl

  2. Radiation Oncology, University of Southern California, Los Angeles, CA, USA

    Adam Garsa

Authors
  1. Michael Wahl
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  2. Adam Garsa
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Corresponding author

Correspondence to Adam Garsa .

Editor information

Editors and Affiliations

  1. The Oregon Clinic, Providence St. Vincent Medical Center, Portland, OR, USA

    Eric K. Hansen

  2. Department of Radiation Oncology, University of California, San Franc, SAN FRANCISCO, CA, USA

    Mack Roach III

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Wahl, M., Garsa, A. (2018). Mesothelioma and Thymic Tumors. In: Hansen, E., Roach III, M. (eds) Handbook of Evidence-Based Radiation Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-62642-0_16

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  • DOI: https://doi.org/10.1007/978-3-319-62642-0_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62641-3

  • Online ISBN: 978-3-319-62642-0

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