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Oncoimmunology pp 641–655Cite as

Current Status of Immuno-Oncology in Hematologic Cancers

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Abstract

Harnessing the immune system in order to eliminate malignant cells has been a long-standing dream for all hematologists and oncologists. Hematologists paved the way with allogeneic hematopoietic stem cell transplantation (HSCT), which was the first successful demonstration of the potential of immunotherapy in cancer, when the benefit of graft versus leukemia was clearly demonstrated. Though allogeneic HSCT is now routinely used in the clinic, major limitations include short- and long-term toxicities, the difficulty to obtain a stem cell graft, and the limited number of hematological cancers that can benefit from this therapy. It took several decades of intensive research to develop and validate other strategies that could expand the field of immunotherapies. Targeting cellular antigens expressed at the surface of malignant cells was the first step, as illustrated by the quintessential example of the anti-CD20 monoclonal antibody (mAb) rituximab.

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Authors and Affiliations

  1. Gustave Roussy Cancer Campus (GRCC), Villejuif, France

    Bertrand Routy & David Ghez

  2. Institut National de la Santé Et de la Recherche Medicale (INSERM) U1015, Villejuif, France

    Bertrand Routy & David Ghez

  3. Equipe Labellisée—Ligue Nationale contre le Cancer, Villejuif, France

    Bertrand Routy & David Ghez

  4. Univ. Paris-Sud, Université Paris-Saclay, Gustave Roussy, Villejuif, France

    Bertrand Routy & David Ghez

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  1. Gustave Roussy Cancer Center , Villejuif Cedex, France

    Laurence Zitvogel

  2. Gustave Roussy Cancer Center , Villejuif Cedex, France

    Guido Kroemer

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Routy, B., Ghez, D. (2018). Current Status of Immuno-Oncology in Hematologic Cancers. In: Zitvogel, L., Kroemer, G. (eds) Oncoimmunology. Springer, Cham. https://doi.org/10.1007/978-3-319-62431-0_38

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