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Pharmacology: General Concepts

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Basic Sciences in Anesthesia

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Abstract

Medicine is intimately associated with a thorough understanding of clinical pharmacology. Many drugs have been discovered by observing natural materials—for example, plants—and their effects on animals. The physical effect of a drug, either positive or negative, can be observed without the knowledge of its mechanism of action. Modern drug discovery takes a different approach. Starting with a hypothesis that a certain protein is implicated in a disease, small molecules are screened for targeting the protein for the therapeutic effect; these are ultimately tested for a desired effect in basic science and clinical trials. The study of the interaction of the drug with the physiology of the body is the basis of clinical pharmacology.

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Author information

Authors and Affiliations

  1. Department of General Anesthesia, Cleveland Clinic Foundation, Cleveland, OH, USA

    Yaqi Hu

  2. Departments of General Anesthesiology and Outcomes Research, Anesthesia Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Kamal Maheshwari

Authors
  1. Yaqi Hu
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  2. Kamal Maheshwari
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Corresponding author

Correspondence to Yaqi Hu .

Editor information

Editors and Affiliations

  1. Departments of General Anesthesia and Outcomes Research, Anesthesiology Institute, Cleveland Clinic Lerner College of Medicine, Case Western University, Cleveland, OH, USA

    Ehab Farag

  2. Center for Anesthesiology Education, Anesthesiology Institute, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, USA

    Maged Argalious

  3. Department of General Anesthesia, Anesthesiology Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA

    John E. Tetzlaff

  4. Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA, USA

    Deepak Sharma

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Hu, Y., Maheshwari, K. (2018). Pharmacology: General Concepts. In: Farag, E., Argalious, M., Tetzlaff, J.E., Sharma, D. (eds) Basic Sciences in Anesthesia. Springer, Cham. https://doi.org/10.1007/978-3-319-62067-1_5

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  • DOI: https://doi.org/10.1007/978-3-319-62067-1_5

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-62065-7

  • Online ISBN: 978-3-319-62067-1

  • eBook Packages: MedicineMedicine (R0)

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