Dissipative Particle Dynamics Study of Alginate/Gelatin Aerogels Obtained by Supercritical Drying

  • Simona ConcilioEmail author
  • Stefano PiottoEmail author
  • Lucia Sessa
  • Lucia Baldino
  • Stefano Cardea
  • Ernesto Reverchon
Part of the Lecture Notes in Bioengineering book series (LNBE)


The properties of alginate/gelatin (A/G) interpenetrated polymer networks have been studied by dissipative particle dynamics (DPD) simulations. The simulation predicted some mechanical properties of A/G blends with different A/G ratios in water. Results from new synthesized aerogels have been used to validate the range of exploitation of the DPD simulations. Good mechanical and morphological properties of the aerogels have been achieved from aerogels derived from hydrogels with water content higher than 95%. DPD simulation results indicated that an optimal shear viscosity is reached for a composition of 95% water, 3% alginate and 2% gelatin. Furthermore, this approach can be of great interest in designing novel materials.


DPD Hydrogels Supercritical drying 


  1. 1.
    Autissier, A., Le Visage, C., Pouzet, C., Chaubet, F., Letourneur, D.: Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process. Acta Biomater. 6(9), 3640–3648 (2010)CrossRefGoogle Scholar
  2. 2.
    Jawad, H., Lyon, A.R., Harding, S.E., Ali, N.N., Boccaccini, A.R.: Myocardial tissue engineering. Br. Med. Bull. 87(1), 31–47 (2008)CrossRefGoogle Scholar
  3. 3.
    Baldwin, A.D., Kiick, K.L.: Polysaccharide-modified synthetic polymeric biomaterials. Pept. Sci. 94(1), 128–140 (2010)CrossRefGoogle Scholar
  4. 4.
    Freeman, I., Cohen, S.: The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. Biomaterials 30(11), 2122–2131 (2009)CrossRefGoogle Scholar
  5. 5.
    Wu, X., Liu, Y., Li, X., Wen, P., Zhang, Y., Long, Y., Wang, X., Guo, Y., Xing, F., Gao, J.: Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. Acta Biomater. 6(3), 1167–1177 (2010)CrossRefGoogle Scholar
  6. 6.
    Inzana, J.A., Olvera, D., Fuller, S.M., Kelly, J.P., Graeve, O.A., Schwarz, E.M., Kates, S.L., Awad, H.A.: 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35(13), 4026–4034 (2014)CrossRefGoogle Scholar
  7. 7.
    Lopez, D.H., Fiol-deRoque, M.A., Noguera-Salva, M.A., Teres, S., Campana, F., Piotto, S., Castro, J.A., Mohaibes, R.J., Escriba, P.V., Busquets, X.: 2-hydroxy arachidonic acid: a new non-steroidal anti-inflammatory drug. PLoS ONE 8(8), e72052 (2013)CrossRefGoogle Scholar
  8. 8.
    Piotto, S., Concilio, S., Bianchino, E., Iannelli, P., Lopez, D.J., Teres, S., Ibarguren, M., Barcelo-Coblijn, G., Martin, M.L., Guardiola-Serrano, F., Alonso-Sande, M., Funari, S.S., Busquets, X., Escriba, P.V.: Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochem. Biophys. Acta. 1838(6), 1628–1637 (2014)CrossRefGoogle Scholar
  9. 9.
    Piotto, S., Trapani, A., Bianchino, E., Ibarguren, M., Lopez, D.J., Busquets, X., Concilio, S.: The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes. Biochem. Biophys. Acta. 1838(6), 1509–1517 (2014)CrossRefGoogle Scholar
  10. 10.
    Piotto, S., Concilio, S., Sessa, L., Porta, A., Calabrese, E.C., Zanfardino, A., Varcamonti, M., Iannelli, P.: Small azobenzene derivatives active against bacteria and fungi. Eur. J. Med. Chem. 68(178–184 (2013)Google Scholar
  11. 11.
    Piotto, S., Concilio, S., Sessa, L., Iannelli, P., Porta, A., Calabrese, E.C., Galdi, M.R., Incarnato, L.: Novel antimicrobial polymer films active against bacteria and fungi. Polym. Compos. 34(9), 1489–1492 (2013)CrossRefGoogle Scholar
  12. 12.
    Cheng, Y., Lu, L., Zhang, W., Shi, J., Cao, Y.: Reinforced low density alginate-based aerogels: preparation, hydrophobic modification and characterization. Carbohyd. Polym. 88(3), 1093–1099 (2012)CrossRefGoogle Scholar
  13. 13.
    Yamamoto, M., James, D., Li, H., Butler, J., Rafii, S., Rabbany, S.: Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold. Tissue Eng. Part A 16(1), 299–308 (2009)CrossRefGoogle Scholar
  14. 14.
    Zhang, F., He, C., Cao, L., Feng, W., Wang, H., Mo, X., Wang, J.: Fabrication of gelatin—hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. Int. J. Biol. Macromol. 48(3), 474–481 (2011)CrossRefGoogle Scholar
  15. 15.
    Baldino, L., Concilio, S., Cardea, S., Reverchon, E.: Interpenetration of natural polymer aerogels by supercritical drying. Polymers 8(4), 106 (2016)CrossRefGoogle Scholar
  16. 16.
    Baldino, L., Concilio, S., Cardea, S., De Marco, I., Reverchon, E.: Complete glutaraldehyde elimination during chitosan hydrogel drying by SC-CO2 processing. J. Supercrit. Fluids 103(70–76 (2015)Google Scholar
  17. 17.
    Groot, R.D., Warren, P.B.: Dissipative particle dynamics: bridging the gap between atomistic and mesoscopic simulation. J. Chem. Phys. 107(4423–4435 (1997)Google Scholar
  18. 18.
    Bianchino, E., Piotto, S., Mavelli, F., Curri, M.L., Striccoli, M.: DPD simulations of PMMA-Oleic acid mixture behaviour in organic capped nanoparticle based polymer nanocomposite. Macromol. Symp. 286(1), 156–163 (2009)CrossRefGoogle Scholar
  19. 19.
    Caracciolo, G., Piotto, S., Bombelli, C., Caminiti, R., Mancini, G.: Segregation and phase transition in mixed lipid films. Langmuir 21(20), 9137–9142 (2005)CrossRefGoogle Scholar
  20. 20.
    Amenitsch, H., Bombelli, C., Borocci, S., Caminiti, R., Ceccacci, F., Concilio, S., La Mesa, C., Mancini, G., Piotto, S., Rappolt, M.: Segregation into domains observed in liquid crystal phases: comparison of experimental and theoretical data. Soft Matter 7(7), 3392–3403 (2011)CrossRefGoogle Scholar
  21. 21.
    Vishnyakov, A., Talaga, D.S., Neimark, A.V.: DPD simulation of protein conformations: from alpha-Helices to beta-structures. J. Phys. Chem. Lett. 3(21), 3081–3087 (2012)CrossRefGoogle Scholar

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Industrial EngineeringUniversity of SalernoFiscianoItaly
  2. 2.Department of PharmacyUniversity of SalernoFiscianoItaly

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