Abstract
The properties of alginate/gelatin (A/G) interpenetrated polymer networks have been studied by dissipative particle dynamics (DPD) simulations. The simulation predicted some mechanical properties of A/G blends with different A/G ratios in water. Results from new synthesized aerogels have been used to validate the range of exploitation of the DPD simulations. Good mechanical and morphological properties of the aerogels have been achieved from aerogels derived from hydrogels with water content higher than 95%. DPD simulation results indicated that an optimal shear viscosity is reached for a composition of 95% water, 3% alginate and 2% gelatin. Furthermore, this approach can be of great interest in designing novel materials.
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References
Autissier, A., Le Visage, C., Pouzet, C., Chaubet, F., Letourneur, D.: Fabrication of porous polysaccharide-based scaffolds using a combined freeze-drying/cross-linking process. Acta Biomater. 6(9), 3640–3648 (2010)
Jawad, H., Lyon, A.R., Harding, S.E., Ali, N.N., Boccaccini, A.R.: Myocardial tissue engineering. Br. Med. Bull. 87(1), 31–47 (2008)
Baldwin, A.D., Kiick, K.L.: Polysaccharide-modified synthetic polymeric biomaterials. Pept. Sci. 94(1), 128–140 (2010)
Freeman, I., Cohen, S.: The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. Biomaterials 30(11), 2122–2131 (2009)
Wu, X., Liu, Y., Li, X., Wen, P., Zhang, Y., Long, Y., Wang, X., Guo, Y., Xing, F., Gao, J.: Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. Acta Biomater. 6(3), 1167–1177 (2010)
Inzana, J.A., Olvera, D., Fuller, S.M., Kelly, J.P., Graeve, O.A., Schwarz, E.M., Kates, S.L., Awad, H.A.: 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35(13), 4026–4034 (2014)
Lopez, D.H., Fiol-deRoque, M.A., Noguera-Salva, M.A., Teres, S., Campana, F., Piotto, S., Castro, J.A., Mohaibes, R.J., Escriba, P.V., Busquets, X.: 2-hydroxy arachidonic acid: a new non-steroidal anti-inflammatory drug. PLoS ONE 8(8), e72052 (2013)
Piotto, S., Concilio, S., Bianchino, E., Iannelli, P., Lopez, D.J., Teres, S., Ibarguren, M., Barcelo-Coblijn, G., Martin, M.L., Guardiola-Serrano, F., Alonso-Sande, M., Funari, S.S., Busquets, X., Escriba, P.V.: Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets. Biochem. Biophys. Acta. 1838(6), 1628–1637 (2014)
Piotto, S., Trapani, A., Bianchino, E., Ibarguren, M., Lopez, D.J., Busquets, X., Concilio, S.: The effect of hydroxylated fatty acid-containing phospholipids in the remodeling of lipid membranes. Biochem. Biophys. Acta. 1838(6), 1509–1517 (2014)
Piotto, S., Concilio, S., Sessa, L., Porta, A., Calabrese, E.C., Zanfardino, A., Varcamonti, M., Iannelli, P.: Small azobenzene derivatives active against bacteria and fungi. Eur. J. Med. Chem. 68(178–184 (2013)
Piotto, S., Concilio, S., Sessa, L., Iannelli, P., Porta, A., Calabrese, E.C., Galdi, M.R., Incarnato, L.: Novel antimicrobial polymer films active against bacteria and fungi. Polym. Compos. 34(9), 1489–1492 (2013)
Cheng, Y., Lu, L., Zhang, W., Shi, J., Cao, Y.: Reinforced low density alginate-based aerogels: preparation, hydrophobic modification and characterization. Carbohyd. Polym. 88(3), 1093–1099 (2012)
Yamamoto, M., James, D., Li, H., Butler, J., Rafii, S., Rabbany, S.: Generation of stable co-cultures of vascular cells in a honeycomb alginate scaffold. Tissue Eng. Part A 16(1), 299–308 (2009)
Zhang, F., He, C., Cao, L., Feng, W., Wang, H., Mo, X., Wang, J.: Fabrication of gelatin—hyaluronic acid hybrid scaffolds with tunable porous structures for soft tissue engineering. Int. J. Biol. Macromol. 48(3), 474–481 (2011)
Baldino, L., Concilio, S., Cardea, S., Reverchon, E.: Interpenetration of natural polymer aerogels by supercritical drying. Polymers 8(4), 106 (2016)
Baldino, L., Concilio, S., Cardea, S., De Marco, I., Reverchon, E.: Complete glutaraldehyde elimination during chitosan hydrogel drying by SC-CO2 processing. J. Supercrit. Fluids 103(70–76 (2015)
Groot, R.D., Warren, P.B.: Dissipative particle dynamics: bridging the gap between atomistic and mesoscopic simulation. J. Chem. Phys. 107(4423–4435 (1997)
Bianchino, E., Piotto, S., Mavelli, F., Curri, M.L., Striccoli, M.: DPD simulations of PMMA-Oleic acid mixture behaviour in organic capped nanoparticle based polymer nanocomposite. Macromol. Symp. 286(1), 156–163 (2009)
Caracciolo, G., Piotto, S., Bombelli, C., Caminiti, R., Mancini, G.: Segregation and phase transition in mixed lipid films. Langmuir 21(20), 9137–9142 (2005)
Amenitsch, H., Bombelli, C., Borocci, S., Caminiti, R., Ceccacci, F., Concilio, S., La Mesa, C., Mancini, G., Piotto, S., Rappolt, M.: Segregation into domains observed in liquid crystal phases: comparison of experimental and theoretical data. Soft Matter 7(7), 3392–3403 (2011)
Vishnyakov, A., Talaga, D.S., Neimark, A.V.: DPD simulation of protein conformations: from alpha-Helices to beta-structures. J. Phys. Chem. Lett. 3(21), 3081–3087 (2012)
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Concilio, S., Piotto, S., Sessa, L., Baldino, L., Cardea, S., Reverchon, E. (2018). Dissipative Particle Dynamics Study of Alginate/Gelatin Aerogels Obtained by Supercritical Drying. In: Piotto, S., Rossi, F., Concilio, S., Reverchon, E., Cattaneo, G. (eds) Advances in Bionanomaterials. Lecture Notes in Bioengineering. Springer, Cham. https://doi.org/10.1007/978-3-319-62027-5_7
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