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A Computational Approach to the Design of Scaffolds for Bone Tissue Engineering

  • Antonio BoccaccioEmail author
  • Antonio Emmanuele Uva
  • Michele Fiorentino
  • Vitoantonio Bevilacqua
  • Carmine Pappalettere
  • Giuseppe Monno
Chapter
Part of the Lecture Notes in Bioengineering book series (LNBE)

Abstract

Design of scaffolds for tissue engineering entails multi-disciplinary and multi-scale aspects. Since in vivo analysis of the tissue regeneration process is quite difficult in terms of selecting experimental protocols and requires considerable amount of time, a variety of numerical models have been developed to simulate mechanisms of tissue differentiation. The tremendous enhancement in computing power led researchers to develop more and more sophisticated models mostly based on finite element techniques and mechano-regulation computational models. In this article, we present an algorithm that combines the finite element model of an open-porous scaffold, a numerical optimization routine and a mechanobiological model. This algorithm has been utilized to determine both, the best scaffold geometry and the best load value (to apply on the scaffold) that allow the bone formation to be maximized.

Keywords

Geometry optimization Scaffold micro-architecture Bone tissue scaffold Computational mechanobiology 

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Antonio Boccaccio
    • 1
    Email author
  • Antonio Emmanuele Uva
    • 1
  • Michele Fiorentino
    • 1
  • Vitoantonio Bevilacqua
    • 2
  • Carmine Pappalettere
    • 1
  • Giuseppe Monno
    • 1
  1. 1.Dipartimento di MeccanicaMatematica e Management, Politecnico di BariBariItaly
  2. 2.Dipartimento di Ingegneria Elettrica e Dell‘Informazione Politecnico di BariBariItaly

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