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Benign and Malignant Ultrasound Semiology

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Abstract

Ultrasound (US) is the method of choice to differentiate cystic from solid masses seen by mammography and evaluate palpable lumps in women under the age of 30. With the advances in equipment technology and radiologist experience, differentiating benign and malignant ultrasound abnormalities although challenging is still achievable. The simple breast cyst is the most common benign abnormality. The clinical value of documenting a mammographic density by US as cystic alleviates the need for biopsy or aspiration and reduces the BIRADS score from 3 to 2. Types of cysts whether simple, complicated or complex will be discussed together with their diagnostic criteria. Characteristics of benign and malignant solid masses will be described along with specific pathological types and their key diagnostic principles. The theory of the sick lobe has correlated the radiologic—pathologic diagnosis of multifocality/multicentricity, intraductal spread and tumour extent with the principle that breast cancer is not necessarily small at its earliest stages of development; on the contrary, it is widespread and multifocal in the majority of cases.

A perfect world is one in which a radiologist can ideally differentiate a benign from a malignant breast abnormality. However, differences in operator experience, equipment and diversity of abnormalities have made this a difficult task. The large number of unnecessary biopsies performed worldwide has led to a rising concern and adverse effect on women, decreasing their appetite for screening. Ultrasound definitely has an important role in the workup of a screening or diagnostic mammogram and in guiding interventional procedures. Understanding breast anatomy within the concept of the sick lobe theory is an important factor in implementing diagnostic criteria.

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References

  1. Berg WA, Campassi CI, Loffe OB. Cystic lesions of the breast: sonographic-pathologic correlation. Radiology. 2003;227(1):183–191.2.

    Article  PubMed  Google Scholar 

  2. Mendelson EB, Berg WA, Merritt CR. Towards a standardized breast ultrasound lexicon, BI-RADS: ultrasound. Semin Roentgenol. 2001;36(3):217–25.

    Article  CAS  PubMed  Google Scholar 

  3. Hilton SV, Leopold GR, Olson LK, Willson SA. Real time breast ultrasonography: application in 300 consequetive patients. AJR. 1986;147:479–86.

    Article  CAS  PubMed  Google Scholar 

  4. Jellins J, Kossof G, Reeve TS. Detection and classification of liquid filled masses in the breast by gray scale echography. Radiology. 1977;125:205–12.

    Article  CAS  PubMed  Google Scholar 

  5. Doshi DJ, March DE, Crisi MG, Coughlin BF. Complex cystic breast masses: diagnostic approach and imaging pathologic correlation. Radiographics. 2007;27:S53–64.

    Article  PubMed  Google Scholar 

  6. Stavros AT. Sonographic evaluation of breast cysts. In:Breast ultrasound. Philadelphia, PA: Lippincott Williams & Wilkins; 2004. p. 276–350.

    Google Scholar 

  7. Venta LA, Kim JP, Pelloski CE, Morrow M. Management of complex breast cysts. AJR Am J Roentgenol. 1999;173(5):1331–6.

    Article  CAS  PubMed  Google Scholar 

  8. Doshi DJ, March DE, Coughlin BF, Crisi GM. Accuracy of ultrasound-guided percutaneous biopsy of complex cystic breast masses. In:Radiological Society of North America scientific assembly and annual meeting program. Oak Brook, Ill: Radiological Society of North 1- Radiological Society of North America 655; 2006.

    Google Scholar 

  9. Rahbar G, Sie AC, Hansen GC, Prince JS, Melany ML, Reynolds HE, Jackson VP, Sayre JW, Bassett LW. Benign versus malignant solid breast masses: US differentiation. Radiology. 1999;213(3):889–94.

    Article  CAS  PubMed  Google Scholar 

  10. Stavros AT. Benign solid nodules; specific pathologic diagnosis. In:Breast ultrasound. Philadelphia, PA: Lippincott Williams & Wilkins; 2004. p. 529–96.

    Google Scholar 

  11. Tot T. DCIS, cytokeratins, and the theory of the sick lobe. Virchows Arch. 2005;447:1–8.

    Article  PubMed  Google Scholar 

  12. Tot T. The theory of the sick breast lobe and the possible consequences. Int J Surg Pathol. 2007;15:369–75.

    Article  PubMed  Google Scholar 

  13. Tot T. The theory of the sick lobe. Breast Cancer. 2011:1–17. https://doi.org/10.1007/978-1-84996-314-5_1.

  14. Tabar L, Chen HT, Yen MFA, Tot T, Tung TH, Chen LS, Chiu YH, Duffy SW, Smith RA. Mammographic features can predict long term outcomes reliably in women with 1-14mm invasive carcinoma. Cancer. 2004;101:1745–59.

    Article  PubMed  Google Scholar 

  15. Tot T, Tabar L. Radiologic-pathologic correlation of ductal carcinoma insitu of the breast using 2 and 3 dimensional large histologic sections. Semin Breast Dis. 2005;8:144–51.

    Article  Google Scholar 

  16. Stavros AT. Malignant solid nodules; specific types. In:Breast ultrasound. Philadelphia, PA: Lippincott Williams & Wilkins; 2004. p. 597–688.

    Google Scholar 

  17. Mai KT, Yazdi HM, Burns BF, Perkins DG. Pattern of distribution of intraductal and infiltrating ductal carcinoma: three dimensional study using serial coronal giant sections of the breast. Hum Pathol. 2000;31:464–74.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Norran Hussein Said M.D., F.R.C.R. .

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Said, N.H., Selim, A. (2018). Benign and Malignant Ultrasound Semiology. In: Amy, D. (eds) Lobar Approach to Breast Ultrasound. Springer, Cham. https://doi.org/10.1007/978-3-319-61681-0_6

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  • DOI: https://doi.org/10.1007/978-3-319-61681-0_6

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-61681-0

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