Abstract
Multicomponent reactions (MCRs) are convergent chemical processes that involve condensation of more than two reactants to form a product, in which basically all or most of the atoms contribute to the newly formed molecule. Usually, MCRs involve the formation of multiple bonds in a single operation without isolating the intermediates or changing the reaction conditions, allowing the straightforward creation of molecular diversity and complexity from simple and readily available substrates. Moreover, the sustainable aspects of MCRs have been recently highlighted: atom economy and step efficiency reduce the number of intermediate steps, functional group manipulations, and use of protecting groups. All these characteristics explain the renewed interest of the synthetic community for MCRs in recent years.
In this chapter, recent advances in the MCRs involving metal carbenes via metal carbene migratory insertion will be discussed, based on significant examples appeared in the literature. We will also focus on the recent developments on the integration of this type of reaction with traditional cross-coupling processes. In recent years, different groups have developed such type of reactions combining classical cross-coupling transformations and metal-stabilized carbene processes with the aim to develop novel strategies for the formation of C-C and C-heteroatom bonds.
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Moni, L., Basso, A., Riva, R. (2017). Combination of Cross-Coupling and Metal Carbene Transformations for the Development of New Multicomponent Reactions. In: Kaneko, S., et al. Carbon-related Materials in Recognition of Nobel Lectures by Prof. Akira Suzuki in ICCE. Springer, Cham. https://doi.org/10.1007/978-3-319-61651-3_12
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