Advertisement

Mast Cells and Interstitial Cystitis

  • Frank Aldenborg
  • Magnus FallEmail author
  • Lennart Enerbäck
Chapter
  • 470 Downloads

Abstract

Mast cells (MC) are tissue-resident immune cells that participate in first line host defense, responding to allergic challenge and pathogen attacks. Following appropriate stimulation they release immuno-modulators, and vaso- and neuroactive compounds. Early reports suggest that MCs are innervated [1] and their anatomical proximity to vasculature and nerve fibers underpin the likelihood of functioning neuro-immune interfaces. The biological role of MCs is diversified.

References

  1. 1.
    Newson B, Dahlstrom A, Enerback L, Ahlman H. Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscience. 1983;10(2):565–70.CrossRefPubMedGoogle Scholar
  2. 2.
    Larsen S, Thompson SA, Hald T, Barnard RJ, Gilpin CJ, Dixon JS, et al. Mast cells in interstitial cystitis. Br J Urol. 1982;54(3):283–6.CrossRefPubMedGoogle Scholar
  3. 3.
    Kastrup J, Hald T, Larsen S, Nielsen VG. Histamine content and mast cell count of detrusor muscle in patients with interstitial cystitis and other types of chronic cystitis. Br J Urol. 1983;55(5):495–500.CrossRefPubMedGoogle Scholar
  4. 4.
    Enerbäck L. Mast cells in rat gastrointestinal mucosa. I. Effect of fixation. Acta Pathol Microbiol Scand. 1966;66:289–302.CrossRefPubMedGoogle Scholar
  5. 5.
    Aldenborg F, Fall M, Enerbäck L. Proliferation and transepithelial migration of mucosal mast cells in interstitial cystitis. Immunology. 1986;58:411–6.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Irani A-MA, Bradford TR, Kepley CL, Schechter NM, Schwartz LB. Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem. 1989;37:1509–15.CrossRefPubMedGoogle Scholar
  7. 7.
    Peeker R, Fall M, Enerbäck L, Aldenborg F. Recruitment, distribution and phenotypes of mast cells in interstitial cystitis. J Urol. 2000;163:1009–15.CrossRefPubMedGoogle Scholar
  8. 8.
    Larsen M, Mortensen S, Nordling J, Horn T. Quantifying mast cells in bladder pain syndrome by immunohistochemical analysis. BJU Int. 2008;102:204–7.CrossRefPubMedGoogle Scholar
  9. 9.
    van de Merwe JP, Nordling J, Bouchelouche P, Bouchelouche K, Cervigni M, Daha LK, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7.CrossRefPubMedGoogle Scholar
  10. 10.
    Theoarides TC, Pang X, Letourneau R, Sant GR. Interstitial cystitis: a neuroimmunoendocrine disorder. Ann N Y Acad Sci. 1998;840:619–34.CrossRefGoogle Scholar
  11. 11.
    Aich A, Afrin L, Gupta K. Mast cell-mediated mechanisms of nociception. Int J Mol Sci. 2015;4(16):29069–92.CrossRefGoogle Scholar
  12. 12.
    Fall M, Johansson SL, Vahlne A. A clinicopathological and virological study of interstitial cystitis. J Urol. 1985;133(5):771–3.CrossRefPubMedGoogle Scholar
  13. 13.
    Johansson SL, Fall M. Clinical features and spectrum of light microscopic changes in interstitial cystitis. J Urol. 1990;143(6):1118–24.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Frank Aldenborg
    • 1
  • Magnus Fall
    • 2
    Email author
  • Lennart Enerbäck
    • 1
  1. 1.Department of PathologySahlgrenska Academy at the University of GothenburgGöteborgSweden
  2. 2.Department of UrologyInstitute of Clinical Sciences, Sahlgrenska Academy at the University of GothenburgGöteborgSweden

Personalised recommendations