Mast Cells and Interstitial Cystitis
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Mast cells (MC) are tissue-resident immune cells that participate in first line host defense, responding to allergic challenge and pathogen attacks. Following appropriate stimulation they release immuno-modulators, and vaso- and neuroactive compounds. Early reports suggest that MCs are innervated  and their anatomical proximity to vasculature and nerve fibers underpin the likelihood of functioning neuro-immune interfaces. The biological role of MCs is diversified.