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Interstitial Cystitis: Animal Models

  • Tony BuffingtonEmail author
  • Michael R. RuggieriSr.
  • David J. Klumpp
Chapter

Abstract

In 1990, although the etiology and pathogenesis of the condition then referred to as “interstitial cystitis” (IC) was admitted to be largely or even completely unknown, the widely held implicit working assumptions held that it is a bladder disease. These assumptions implied that if we could discover and correct what was wrong with the bladder itself then we could cure the condition. These assumptions have proved to be largely off base. At that time, the previous suggestions that IC might have a primarily autoimmune or infectious etiology were largely abandoned. The autoimmune hypothesis still remains but has yet to be either been proven nor disproven conclusively.

Keywords

Interstitial Cystitis Bladder Disease Autoimmune Hypothesis Bladder Surface Mucin Adverse Early Life Experiences 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Kohn IJ, Filer-Maerten S, Whitmore KE, Hanno PM, Ruggieri MR. Lack of effect following repeated in vivo exposure of the rabbit urinary bladder to urine from interstitial cystitis patients at low infusion volumes. Neurourol Urodyn. 1998;17(2):147–52.CrossRefPubMedGoogle Scholar
  2. 2.
    Ruggieri MR, Chelsky MJ, Rosen SI, Shickley TJ, Hanno PM. Current findings and future research avenues in the study of interstitial cystitis. Urol Clin North Am. 1994;21(1):163–76.PubMedGoogle Scholar
  3. 3.
    Keay SK, Birder LA, Chai TC. Evidence for bladder urothelial pathophysiology in functional bladder disorders. Biomed Res Int. 2014;2014:865463.CrossRefPubMedPubMedCentralGoogle Scholar
  4. 4.
    Chew DJ, Bartges JW, Adams LG, Kruger JM, Buffington CAT. Evaluation of pentosan polysulfate sodium for Feline Interstitial Cystitis: a randomized, placebo-controlled clinical trial. In preparation. 2008.Google Scholar
  5. 5.
    Nickel JC, Herschorn S, Whitmore KE, Forrest JB, Hu P, Friedman AJ, et al. Pentosan polysulfate sodium for treatment of interstitial cystitis/bladder pain syndrome: insights from a randomized, double-blind, placebo-controlled study. J Urol. 2014;193(3):857–62.CrossRefPubMedGoogle Scholar
  6. 6.
    Hanno PM, Wolf S. Guidelines Q&A: diagnosis and treatment of interstitial cystitis/bladder pain syndrome. Health Policy Brief. 2014;21(1).Google Scholar
  7. 7.
    Rudick CN, Jiang M, Yaggie RE, Pavlov VI, Done J, Heckman CJ, et al. O-antigen modulates infection-induced pain states. PLoS One. 2012;7(8):e41273.CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    DeBerry J, Ness TJ, Robbins MT, Randich A. Inflammation-induced enhancement of the visceromotor reflex to urinary bladder distention: modulation by endogenous opioids and the effects of early-in-life experience with bladder inflammation. J Pain. 2007;8(12):914–23.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Randich A, Uzzell T, DeBerry JJ, Ness TJ. Neonatal urinary bladder inflammation produces adult bladder hypersensitivity. J Pain. 2006;7(7):469–79.CrossRefPubMedGoogle Scholar
  10. 10.
    Million M, Wang L, Stenzel-Poore MP, Coste S, Yuan PQ, Lamy C, et al. Enhanced pelvic responses to stressors in female CRF-overexpressing mice. Am J Physiol Regul Integr Comp Physiol. 2007;292(4):R1429–38.CrossRefPubMedGoogle Scholar
  11. 11.
    Larauche M, Mulak A, Tache Y. Stress and visceral pain: from animal models to clinical therapies. Exp Neurol. 2012;233(1):49–67.CrossRefPubMedGoogle Scholar
  12. 12.
    Lee UJ, Ackerman AL, Wu A, Zhang R, Leung J, Bradesi S, et al. Chronic psychological stress in high-anxiety rats induces sustained bladder hyperalgesia. Physiol Behav. 2015;139:541–8.CrossRefPubMedGoogle Scholar
  13. 13.
    Pierce AN, Di Silvestro ER, Eller OC, Wang R, Ryals JM, Christianson JA. Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress. Brain Res. 1639;2016:58–73.Google Scholar
  14. 14.
    Buffington CA. Idiopathic cystitis in domestic cats-beyond the lower urinary tract. J Vet Intern Med. 2011;25(4):784–96.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Stella JL, Lord LK, Buffington CA. Sickness behaviors in response to unusual external events in healthy cats and cats with feline interstitial cystitis. J Am Vet Med Assoc. 2011;238(1):67–73.CrossRefPubMedGoogle Scholar
  16. 16.
    Warren JW, Howard FM, Cross RK, Good JL, Weissman MM, Wesselmann U, et al. Antecedent nonbladder syndromes in case-control study of interstitial cystitis/painful bladder syndrome. Urology. 2009;73(1):52–7.CrossRefPubMedGoogle Scholar
  17. 17.
    Buffington CAT, Westropp JL, Chew DJ, Bolus RR. Clinical evaluation of multimodal environmental modification in the management of cats with lower urinary tract signs. J Feline Med Surg. 2006;8:261–8.CrossRefPubMedGoogle Scholar
  18. 18.
    Carney HC, Sadek TP, Curtis TM, Halls V, Heath S, Hutchison P, et al. AAFP and ISFM guidelines for diagnosing and solving house-soiling behavior in cats. J Feline Med Surg. 2014;16(7):579–98.CrossRefPubMedGoogle Scholar
  19. 19.
    Jones CA, Nyberg L. Epidemiology of interstitial cystitis. Urology. 1997;49(5A):2–9.CrossRefPubMedGoogle Scholar
  20. 20.
    Clemens JQ, Meenan RT, Rosetti MC, Gao SY, Calhoun EA. Prevalence and incidence of interstitial cystitis in a managed care population. J Urol. 2005;173(1):98–102; discussion.Google Scholar
  21. 21.
    Miller JL, Rothman I, Bavendam TG, Berger RE. Prostatodynia and interstitial cystitis: one and the same? Urology. 1994;45:587–90.CrossRefGoogle Scholar
  22. 22.
    Suskind AM, Berry SH, Ewing BA, Elliott MN, Suttorp MJ, Clemens JQ. The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study. J Urol. 2013;189(1):141–5.CrossRefPubMedGoogle Scholar
  23. 23.
    Dimitrakov J, Joffe HV, Soldin SJ, Bolus R, Buffington CA, Nickel JC. Adrenocortical hormone abnormalities in men with chronic prostatitis/chronic pelvic pain syndrome. Urology. 2008;71(2):261–6.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Twiss C, Kilpatrick L, Craske M, Buffington CA, Ornitz E, Rodriguez LV, et al. Increased startle responses in interstitial cystitis: evidence for central hyperresponsiveness to visceral related threat. J Urol. 2009;181(5):2127–33.CrossRefPubMedGoogle Scholar
  25. 25.
    Buffington CAT. From animal data to human practice. In: Messelink B, Baranowski A, Hughes J, editors. Abdominal and pelvic pain: from definition to best practice. Washington, DC: IASP Press; 2014. p. 23–35.Google Scholar
  26. 26.
    Heim C, Ehlert U, Hellhammer DH. The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology. 2000;25(1):1–35.CrossRefPubMedGoogle Scholar
  27. 27.
    Gluckman PD, Hanson MA. Mismatch: why our world no longer fits our bodies. Oxford: Oxford University Press; 2006. p. 304.Google Scholar
  28. 28.
    Weaver ICG, Cervoni N, Champagne FA, D’Alessio AC, Sharma S, Seckl JR, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7(8):847–54.CrossRefPubMedGoogle Scholar
  29. 29.
    Koolhaas JM, Korte SM, De Boer SF, Van Der Vegt BJ, Van Reenen CG, Hopster H, et al. Coping styles in animals: current status in behavior and stress-physiology. Neurosci Biobehav Rev. 1999;23(7):925–35.CrossRefPubMedGoogle Scholar
  30. 30.
    Hackshaw KV, Plans-Pujolras M, Rodriguez-Saona LE, Moore MA, Jackson EK, Sforzo GA, et al. A pilot study of health and wellness coaching for fibromyalgia. BMC Musculoskelet Disord. 2016;17(1):457.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Clauw DJ, Schmidt M, Radulovic D, Singer A, Katz P, Bresette J. The relationship between fibromyalgia and interstitial cystitis. J Psychiatr Res. 1997;31(1):125–31.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Tony Buffington
    • 1
    • 2
    Email author
  • Michael R. RuggieriSr.
    • 3
  • David J. Klumpp
    • 4
  1. 1.Department of Medicine and EpidemiologyUC Davis School of Veterinary MedicineDavisUSA
  2. 2.The Ohio State UniversityColumbusUSA
  3. 3.Lewis Katz School of Medicine, Temple UniversityPhiladelphiaUSA
  4. 4.Feinberg School of Medicine, Northwestern UniversityChicagoUSA

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