Interstitial Cystitis: Animal Models

  • Tony BuffingtonEmail author
  • Michael R. RuggieriSr.
  • David J. Klumpp


In 1990, although the etiology and pathogenesis of the condition then referred to as “interstitial cystitis” (IC) was admitted to be largely or even completely unknown, the widely held implicit working assumptions held that it is a bladder disease. These assumptions implied that if we could discover and correct what was wrong with the bladder itself then we could cure the condition. These assumptions have proved to be largely off base. At that time, the previous suggestions that IC might have a primarily autoimmune or infectious etiology were largely abandoned. The autoimmune hypothesis still remains but has yet to be either been proven nor disproven conclusively.


Interstitial Cystitis Bladder Disease Autoimmune Hypothesis Bladder Surface Mucin Adverse Early Life Experiences 
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Tony Buffington
    • 1
    • 2
    Email author
  • Michael R. RuggieriSr.
    • 3
  • David J. Klumpp
    • 4
  1. 1.Department of Medicine and EpidemiologyUC Davis School of Veterinary MedicineDavisUSA
  2. 2.The Ohio State UniversityColumbusUSA
  3. 3.Lewis Katz School of Medicine, Temple UniversityPhiladelphiaUSA
  4. 4.Feinberg School of Medicine, Northwestern UniversityChicagoUSA

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