The Use of Pentosan Polysulfate in the Management of Interstitial Cystitis
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“Interstitial Cystitis” was published in 1988 by Springer Verlag, and was one of the earliest publications detailing the potential role of pentosan polysulfate for the treatment of interstitial cystitis . In an earlier pilot study, Parsons et al., described that this sulfated polysaccharide could improve symptoms in 90% of interstitial cystitis patients . The textbook chapter that followed described the theoretical basis of pentosan polysulfate’s (PPS) action along with data developed from a placebo controlled double-blinded cross over study. Results were not quite as spectacular, but nevertheless promising with 47% of PPS treated patients reporting overall symptom improvement compared to 23% of those receiving placebo. Over the past 35 years, our use of PPS in IC therapy has evolved based upon newer literature and the clinical experience of dedicated practitioners.
- 1.Parsons CL. Interstitial cystitis. Use of pentosan polysulfate in the management of interstitial cystitis. In: Hanno PM, Staskin DR, Krane RJ, Wein AJ, editors. Interstitial cystitis (chapter 17). London: Springer; 1988. p. 163–8.Google Scholar