Advertisement

The Use of Heparin

  • Arndt van OphovenEmail author
Chapter
  • 462 Downloads

Abstract

From its first introduction as a therapeutic agent for IC in 1963 on treatment results of heparin use have been rarely but constantly reported until today. The preferred route of administration is by intravesical instillation although patients suffering from bladder pain syndrome often fear and wish to avoid repetitive catheterization. Thus, the subcutaneous route of administration as reported for the first time by Gunnar Lose in 1983 and summarized in Chap.  15 in the first edition of this book, offers an alternative, less painful and minimal invasive approach. However, in contrast to subcutaneous administration which requires the monitoring of clotting parameters, no such information is required for the safe use of instillations which increases their feasibility regarding follow up monitoring of patients and has added to their preference as a mode of administration.

Keywords

Bladder Pain Syndrome Gunnar Lose Minimal Invasive Approach Intravesical Instillation Intravesical Heparin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Baykal K, Senkul T, Sen B, Karademir K, Adayener C, Erden D. Intravesical heparin and peripheral neuromodulation on interstitial cystitis. Urol Int. 2005;74(4):361–4.CrossRefPubMedGoogle Scholar
  2. 2.
    Kuo HC. Urodynamic results of intravesical heparin therapy for women with frequency urgency syndrome and interstitial cystitis. J Formos Med Assoc. 2001;100(5):309–14.PubMedGoogle Scholar
  3. 3.
    Nomiya A, Naruse T, Niimi A, et al. On- and post-treatment symptom relief by repeated instillations of heparin and alkalized lidocaine in interstitial cystitis. Int J Urol. 2013;20(11):1118–22.CrossRefPubMedGoogle Scholar
  4. 4.
    Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65(1):45–8.CrossRefPubMedGoogle Scholar
  5. 5.
    Parsons CL, Housley T, Schmidt JD, Lebow D. Treatment of interstitial cystitis with intravesical heparin. Br J Urol. 1994;73(5):504–7.CrossRefPubMedGoogle Scholar
  6. 6.
    Parsons CL, Koziol JA, Proctor JG, Zupkas P, Argade S. Heparin and alkalinized lidocaine versus alkalinized lidocaine for treatment of interstitial cystitis symptoms. Can J Urol. 2015;22(2):7739–44.PubMedGoogle Scholar
  7. 7.
    Parsons CL, Zupkas P, Proctor J, et al. Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. J Sex Med. 2012;9(1):207–12.CrossRefPubMedGoogle Scholar
  8. 8.
    Taneja R, Jawade KK. A rational combination of intravesical and systemic agents for the treatment of interstitial cystitis. Scand J Urol Nephrol. 2007;41(6):511–5.CrossRefPubMedGoogle Scholar
  9. 9.
    van Ophoven A, Heinecke A, Hertle L. Safety and efficacy of concurrent application of oral pentosan polysulfate and subcutaneous low-dose heparin for patients with interstitial cystitis. Urology. 2005;66(4):707–11.CrossRefPubMedGoogle Scholar
  10. 10.
    Weaver RG, Dougherty TF, Natoli CA. Recent concepts of interstitial cystitis. J Urol. 1963;89:377–83.CrossRefPubMedGoogle Scholar
  11. 11.
    Welk BK, Teichman JM. Dyspareunia response in patients with interstitial cystitis treated with intravesical lidocaine, bicarbonate, and heparin. Urology. 2008;71(1):67–70.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Neuro-UrologyMarien Hospital Herne, University Hospital Ruhr-Universität BochumHerneGermany

Personalised recommendations