The Use of Heparin

  • Arndt van OphovenEmail author


From its first introduction as a therapeutic agent for IC in 1963 on treatment results of heparin use have been rarely but constantly reported until today. The preferred route of administration is by intravesical instillation although patients suffering from bladder pain syndrome often fear and wish to avoid repetitive catheterization. Thus, the subcutaneous route of administration as reported for the first time by Gunnar Lose in 1983 and summarized in Chap.  15 in the first edition of this book, offers an alternative, less painful and minimal invasive approach. However, in contrast to subcutaneous administration which requires the monitoring of clotting parameters, no such information is required for the safe use of instillations which increases their feasibility regarding follow up monitoring of patients and has added to their preference as a mode of administration.


Bladder Pain Syndrome Gunnar Lose Minimal Invasive Approach Intravesical Instillation Intravesical Heparin 
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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Division of Neuro-UrologyMarien Hospital Herne, University Hospital Ruhr-Universität BochumHerneGermany

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