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Intravesical Therapy of Interstitial Cystitis

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Bladder Pain Syndrome – An Evolution

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Abstract

Flashback to 1989. Bladder Pain Syndrome/Interstitial Cystitis was treated with a variety of off-label therapies, but the standard treatment against which all therapies were measured was intravesical lavage. Dimethyl sulfoxide (DMSO) had been approved a decade earlier (1978) for treatment of interstitial cystitis and remains to this day the only approved intravesical medication for the disorder by the Food and Drug Administration (FDA). Its use for this condition can be credited to Bruce Stewart of the Cleveland Clinic who persisted with an intravesical trial after failing in a transdermal clinical study of refractory patients in the mid-1960’s. It would be 1996 before sodium pentosan polysulfate became only the second approved medication and sole oral approved therapy for the syndrome.

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Authors and Affiliations

  1. Stanford University School of Medicine, Stanford, CA, USA

    Philip Hanno

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  1. Philip Hanno
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Correspondence to Philip Hanno .

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Editors and Affiliations

  1. Stanford University School of Medicine, Stanford, California, USA

    Philip M. Hanno

  2. Department of Urology, Herlev Hospital, Herlev, Denmark

    Jørgen Nordling

  3. St. Elizabeth’s Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

    David R. Staskin

  4. Penn Medicine, Perelman School of Medicine, Perelman Center for Advanced Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA

    Alan J. Wein

  5. Urology, Antwerp University, GGW, Wilrijk, Antwerp, Belgium

    Jean Jacques Wyndaele

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Hanno, P. (2018). Intravesical Therapy of Interstitial Cystitis. In: Hanno, P., Nordling, J., Staskin, D., Wein, A., Wyndaele, J. (eds) Bladder Pain Syndrome – An Evolution. Springer, Cham. https://doi.org/10.1007/978-3-319-61449-6_20

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  • DOI: https://doi.org/10.1007/978-3-319-61449-6_20

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61448-9

  • Online ISBN: 978-3-319-61449-6

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