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Bone Marrow Failure pp 181–192Cite as

Inherited Neutropenias and Their Insights into Cellular and Developmental Biology

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Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

Isolated neutropenia may be either congenital or acquired. Congenital neutropenias result from single gene mutations, where the genes encode a diverse range of proteins involved in granulocytic progenitor expansion, survival, differentiation, cytoskeletal organization, and metabolism. Congenital neutropenias may be associated with non-hematologic abnormalities. While recombinant human granulocyte colony-stimulating factor can improve neutrophil counts, its usage may be associated with mutations in its cognate receptor and herald the transformation to myelodysplastic syndrome or acute myeloid leukemia. Besides serving as a model for understanding bone marrow failure and transformation to myeloid malignancy, these monogenic disorders provide insight into normal cellular and developmental biology of neutrophils and granulopoiesis.

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  1. Division of Pediatric Hematology, Oncology, and Stem Cell Transplantation, Children’s Hospital of Richmond, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA

    Hrishikesh M. Mehta & Seth J. Corey

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  1. Hrishikesh M. Mehta
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  2. Seth J. Corey
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Correspondence to Seth J. Corey .

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Editors and Affiliations

  1. Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA

    Gary M. Kupfer

  2. Department of Pediatrics, George Washington University, Washington, DC, USA

    Gregory H. Reaman

  3. Medpace, Cincinnati, OH, USA

    Franklin O. Smith

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Mehta, H.M., Corey, S.J. (2018). Inherited Neutropenias and Their Insights into Cellular and Developmental Biology. In: Kupfer, G., Reaman, G., Smith, F. (eds) Bone Marrow Failure. Pediatric Oncology. Springer, Cham. https://doi.org/10.1007/978-3-319-61421-2_10

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