Abstract
In children presenting with neurological deficits associated with large parenchymal lesions on imaging, brain tumors and cerebral abscess are typically considered in the differential diagnosis. However, it is important to also consider tumefactive demyelinating lesions, which can be challenging to diagnose. Clinical and radiographic features may help to avoid a brain biopsy. This chapter presents a case of a 14-year-old boy with cognitive impairment and behavioral abnormalities who had large multifocal supratentorial lesions. The case reviews distinguishing signs, symptoms, and ancillary diagnostic tests that can help to distinguish between the potential etiologies.
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Lucchinetti CF, et al. Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis. Brain. 2008;131(Pt 7):1759–75.
Luthra G, et al. Comparative evaluation of fungal, tubercular, and pyogenic brain abscesses with conventional and diffusion MR imaging and proton MR spectroscopy. AJNR Am J Neuroradiol. 2007;28(7):1332–8.
Altintas A, et al. Clinical and radiological characteristics of tumefactive demyelinating lesions: follow-up study. Mult Scler. 2012;18(10):1448–53.
Yao J, et al. Clinical and radiological characteristics of 17 Chinese patients with pathology confirmed tumefactive demyelinating diseases: follow-up study. J Neurol Sci. 2015;348(1–2):153–9.
Hardy TA, Chataway J. Tumefactive demyelination: an approach to diagnosis and management. J Neurol Neurosurg Psychiatry. 2013;84(9):1047–53.
Morin MP, et al. Solitary tumefactive demyelinating lesions in children. J Child Neurol. 2011;26(8):995–9.
Yiu EM, et al. Clinical and magnetic resonance imaging (MRI) distinctions between tumefactive demyelination and brain tumors in children. J Child Neurol. 2014;29(5):654–65.
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Lopez, M.A., Lotze, T.E. (2017). Pediatric Tumefactive Demyelination. In: Waubant, E., Lotze, T. (eds) Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-319-61407-6_7
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DOI: https://doi.org/10.1007/978-3-319-61407-6_7
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