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Neuromyelitis Optica Spectrum Disease with Transverse Myelitis Presentation

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Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics

Abstract

Neuromyelitis optica spectrum disease (NMOSD) can present as a spinal cord syndrome in children. This chapter describes two cases of children presenting with acute transverse myelitis leading to a diagnosis of neuromyelitis optica based upon current diagnostic criteria. The contrasting cases demonstrate the application of the criteria in the setting of aquaporin-4-IgG seronegative and seropositive patients. The clinical scenarios indicate the importance of considering the diagnosis of NMOSD and its associated work-up at the time of an initial presentation of transverse myelitis.

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Author information

Authors and Affiliations

  1. Department of Child Neurology, Morgan Stanley Children’s Hospital of New York, Columbia University Medical Center, 180 Fort Washington Avenue, New York, NY, 10032, USA

    Wendy Vargas M.D.

  2. Department of Neurology, Servicio de Neurologia, Consorcio Hospital General Universitario de Valencia, Avenida Tres Cruces, 2, Valencia, 46014, Spain

    Carlos Quintanilla Bordás M.D.

  3. Multiple Sclerosis and Neuroinflammation Center, University of California, San Francisco, San Francisco, CA, USA

    Carla Francisco M.D.

  4. Clinical Neurology and Pediatrics, Regional Pediatric MS Clinic at UCSF, University of California, San Francisco, 675 Nelson Rising Lane, Suite 221, San Francisco, CA, 94158, USA

    Emmanuelle Waubant M.D., Ph.D.

Authors
  1. Wendy Vargas M.D.
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  2. Carlos Quintanilla Bordás M.D.
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  3. Carla Francisco M.D.
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  4. Emmanuelle Waubant M.D., Ph.D.
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Corresponding authors

Correspondence to Wendy Vargas M.D. or Carlos Quintanilla Bordás M.D. .

Editor information

Editors and Affiliations

  1. Clinical Neurology and Pediatrics, Regional Pediatric MS Clinic at UCSF, University of California San Francisco, San Francisco, California, USA

    Emmanuelle Waubant

  2. Division of Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, USA

    Timothy E. Lotze

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Vargas, W., Bordás, C.Q., Francisco, C., Waubant, E. (2017). Neuromyelitis Optica Spectrum Disease with Transverse Myelitis Presentation. In: Waubant, E., Lotze, T. (eds) Pediatric Demyelinating Diseases of the Central Nervous System and Their Mimics. Springer, Cham. https://doi.org/10.1007/978-3-319-61407-6_32

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  • DOI: https://doi.org/10.1007/978-3-319-61407-6_32

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61405-2

  • Online ISBN: 978-3-319-61407-6

  • eBook Packages: MedicineMedicine (R0)

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