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Early Onset IBD: Endoscopic Features

  • Serena Arrigo
  • Sara Signa
  • Arrigo Barabino
Chapter

Abstract

Very early onset IBD (VEOIBD) is an emerging form of pediatric IBD with distinct features in the pathogenesis and in the phenotype. The clinical pattern is often associated with isolated unclassified pancolitis, increased severity, aggressive progression, more resistant to many of standard therapy. Genetic susceptibility plays a important role in VEOIBD and above all infantile IBD can be the first isolated presentation of a primary immunodeficiency. Genetic screening is mandatory to recognize underlying genetic defect that require targeted treatment as allogeneic hematopoietic stem cell transplantation.

Keywords

Very early onset inflammatory bowel disease (VEOIBD) Infantile IBD unclassified (IBD-U) Primary immunodeficiency (PID) Genetic 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Pediatric Gastroenterology and Endoscopy UnitG. Gaslini Institute—IRCCSGenoaItaly

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