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A Lung Graph–Model for Pulmonary Hypertension and Pulmonary Embolism Detection on DECT Images

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Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 10081))

Abstract

This article presents a novel graph–model approach encoding the relations between the perfusion in several regions of the lung extracted from a geometry–based atlas. Unlike previous approaches that individually analyze regions of the lungs, our method evaluates the entire pulmonary circulatory network for the classification of patients with pulmonary embolism and pulmonary hypertension. An undirected weighted graph with fixed structure is used to encode the network of intensity distributions in Dual Energy Computed Tomography (DECT) images. Results show that the graph–model presented is capable of characterizing a DECT dataset of 30 patients affected with disease and 26 healthy patients, achieving a discrimination accuracy from 0.77 to 0.87 and an AUC between 0.73 and 0.86. This fully automatic graph–model of the lungs constitutes a novel and effective approach for exploring the various patterns of pulmonary perfusion of healthy and diseased patients.

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References

  1. Burrowes, K., Tawhai, M., Clark, A.: Blood flow redistribution and ventilation-perfusion mismatch during embolic pulmonary arterial occlusion. Pulm. Circ. 1(3), 365 (2011)

    Article  Google Scholar 

  2. Chae, E.J., Seo, J.B., Jang, Y.M., Krauß, B., Lee, C.W., Lee, H.J., Song, K.S.: Dual-energy CT for assessment of the severity of acute pulmonary embolism: pulmonary perfusion defect score compared with CT angiographic obstruction score and right ventricular/left ventricular diameter ratio. Am. J. Roentgenol. 194(3), 604–610 (2010)

    Article  Google Scholar 

  3. Chang, C.C., Lin, C.J.: LIBSVM: a library for support vector machines. ACM Trans. Intell. Syst. Technol. 2(3), 1–27 (2011)

    Article  Google Scholar 

  4. Cortes, C., Vapnik, V.: Support-vector networks. Mach. Learn. 20(3), 273–297 (1995)

    MATH  Google Scholar 

  5. Depeursinge, A., Chin, A.C., Leung, A.N., Terrone, D., Bristow, M., Rosen, G., Rubin, D.L.: Automated classification of usual interstitial pneumonia using regional volumetric texture analysis in high-resolution CT. Investig. Radiol. 50(4), 261–267 (2015)

    Article  Google Scholar 

  6. Depeursinge, A., Zrimec, T., Busayarat, S., Müller, H.: 3D lung image retrieval using localized features. In: Medical Imaging 2011: Computer-Aided Diagnosis, vol. 7963, p. 79632E. SPIE, February 2011

    Google Scholar 

  7. Dicente Cid, Y., Depeursinge, A., Foncubierta-Rodríguez, A., Platon, A., Poletti, P.A., Müller, H.: Pulmonary embolism detecton using localized vessel-based features in dual energy CT. In: SPIE Medical Imaging. International Society for Optics and Photonics (2015)

    Google Scholar 

  8. Dicente Cid, Y., Jiménez-del Toro, O.A., Depeursinge, A., Müller, H.: Efficient and fully automatic segmentation of the lungs in CT volumes. In: Goksel, O., et al. (eds.) Proceedings of the VISCERAL Challenge at ISBI. No. 1390 in CEUR Workshop Proceedings, April 2015

    Google Scholar 

  9. Farber, H.: Pulmonary circulation: diseases and their treatment. Eur. Respir. Rev. 21(123), 78 (2012). 3rd Edition

    Google Scholar 

  10. Goksel, O., Foncubierta-Rodríguez, A., Jiménez-del Toro, O.A., Müller, H., Langs, G., Weber, M.A., Menze, B., Eggel, I., Gruenberg, K., Winterstein, M., Holzer, M., Krenn, M., Kontokotsios, G., Metallidis, S., Schaer, R., Taha, A.A., Jakab, A., Salas Fernandez, T., Hanbury, A.: Overview of the VISCERAL challenge at ISBI 2015. In: Goksel, O., et al. (eds.) Proceedings of the VISCERAL Challenge at ISBI, pp. 6–11. No. 1390 in CEUR Workshop Proceedings, April 2015

    Google Scholar 

  11. Kim, N.H., Delcroix, M., Jenkins, D.P., Channick, R., Dartevelle, P., Jansa, P., Lang, I., Madani, M.M., Ogino, H., Pengo, V., Mayer, E.: Chronic thromboembolic pulmonary hypertension. J. Am. Coll. Cardiol. 62(25 SUPPL.), D92–D99 (2013)

    Article  Google Scholar 

  12. Lador, F., Beghetti, M., Rochat, T.: Détection et traitement précoce de l’hypertension artérielle pulmonaire. Revue Médicale Suisse 5, 2317–2321 (2009)

    Google Scholar 

  13. Lee, C., Seo, J., Song, J.W., Kim, M.Y., Lee, H., Park, Y., Chae, E., Jang, Y., Kim, N., Krauß, B.: Evaluation of computer-aided detection and dual energy software in detection of peripheral pulmonary embolism on dual-energy pulmonary CT angiography. Eur. Radiol. 21(1), 54–62 (2011)

    Article  Google Scholar 

  14. Nakazawa, T., Watanabe, Y., Hori, Y., Kiso, K., Higashi, M., Itoh, T., Naito, H.: Lung perfused blood volume images with dual-energy computed tomography for chronic thromboembolic pulmonary hypertension: correlation to scintigraphy with single-photon emission computed tomography. J. Comput. Assist. Tomogr. 35(5), 590–595 (2011)

    Article  Google Scholar 

  15. Richiardi, J., Bunke, H., Van De Ville, D., Achard, S.: Machine learning with brain graphs. IEEE Signal Process. Mag. 30, 58 (2013)

    Article  Google Scholar 

  16. Richiardi, J., Eryilmaz, H., Schwartz, S., Vuilleumier, P., Van De Ville, D.: Decoding brain states from fMRI connectivity graphs. NeuroImage 56(2), 616–626 (2011)

    Article  Google Scholar 

  17. Salvador, R., Suckling, J., Schwarzbauer, C., Bullmore, E.: Undirected graphs of frequency-dependent functional connectivity in whole brain networks. Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 360(1457), 937–946 (2005)

    Article  Google Scholar 

  18. Schwickert, H.C., Schweden, F., Schild, H.H., Piepenburg, R., Düber, C., Kauczor, H.U., Renner, C., Iversen, S., Thelen, M.: Pulmonary arteries and lung parenchyma in chronic pulmonary embolism: preoperative and postoperative CT findings. Radiology 191(2), 351–357 (1994)

    Article  Google Scholar 

  19. Thieme, S.F., Becker, C.R., Hacker, M., Nikolaou, K., Reiser, M.F., Johnson, T.R.C.: Dual energy CT for the assessment of lung perfusion–correlation to scintigraphy. Eur. J. Radiol. 68(3), 369–374 (2008)

    Article  Google Scholar 

  20. Thieme, S.F., Johnson, T.R.C., Lee, C., McWilliams, J., Becker, C.R., Reiser, M.F., Nikolaou, K.: Dual-energy CT for the assessment of contrast material distribution in the pulmonary parenchyma. Am. J. Roentgenol. 193(1), 144–149 (2009)

    Article  Google Scholar 

  21. Thies, C., Metzler, V., Lehmann, T.M., Aach, T.: Formal extraction of biomedical objects by subgraph matching in attributed hierarchical region adjecency graphs. In: Medical Imaging 2004. SPIEProc, vol. 5370, February 2004

    Google Scholar 

  22. Tuder, R.M., Archer, S.L., Dorfmüller, P., Erzurum, S.C., Guignabert, C., Michelakis, E., Rabinovitch, M., Schermuly, R., Stenmark, K.R., Morrell, N.W.: Relevant issues in the pathology and pathobiology of pulmonary hypertension. J. Am. Coll. Cardiol. 62(25 SUPPL.), D4–D12 (2013)

    Article  Google Scholar 

  23. Ukil, S., Reinhardt, J.M.: Anatomy-guided lung lobe segmentation in X-ray CT images. IEEE Trans. Med. Imaging 28(2), 202–214 (2009)

    Article  Google Scholar 

  24. Varoquaux, G., Gramfort, A., Poline, J., Thirion, B.: Brain covariance selection: better individual functional connectivity models using population prior. Nips 10, 2334–2342 (2010)

    Google Scholar 

  25. Zrimec, T., Busayarat, S., Wilson, P.: A 3D model of the human lung. In: Barillot, C., Haynor, D.R., Hellier, P. (eds.) MICCAI 2004. LNCS, vol. 3217, pp. 1074–1075. Springer, Heidelberg (2004). doi:10.1007/978-3-540-30136-3_143

    Chapter  Google Scholar 

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Acknowledgments

This work was partly supported by the Swiss National Science Foundation with the PH4D (320030–146804) and MAGE projects (PZ00P2_154891).

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Correspondence to Yashin Dicente Cid .

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Dicente Cid, Y. et al. (2017). A Lung Graph–Model for Pulmonary Hypertension and Pulmonary Embolism Detection on DECT Images. In: Müller, H., et al. Medical Computer Vision and Bayesian and Graphical Models for Biomedical Imaging. BAMBI MCV 2016 2016. Lecture Notes in Computer Science(), vol 10081. Springer, Cham. https://doi.org/10.1007/978-3-319-61188-4_6

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  • DOI: https://doi.org/10.1007/978-3-319-61188-4_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-61187-7

  • Online ISBN: 978-3-319-61188-4

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