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Crosslinking Results and Literature Overview

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Management of Early Progressive Corneal Ectasia

Abstract

Corneal crosslinking (CXL) is performed in an outpatient setting. Thirty minutes in advance, a systemic analgosedation can be administered. Some surgeons use Pilocarpin 2% eye drops in order to reduce potential thermal and photochemical effects of UVA-radiation on the retina and the lens.

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References

  1. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620–7.

    Article  CAS  PubMed  Google Scholar 

  2. Raiskup F, Theuring A, Pillunat LE, et al. Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: ten-year results. J Cataract Refract Surg. 2015;41:41–6.

    Article  PubMed  Google Scholar 

  3. Caporossi A, Mazzotta C, Baiocchi S, et al. Age-related long-term functional results after riboflavin UV A corneal cross-linking. J Ophthalmol. 2011;2011:608041.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Spoerl E, Zubaty V, Terai N, et al. Influence of high-dose cortisol on the biomechanics of incubated porcine corneal strips. J Refract Surg. 2009;25:S794–8.

    Article  PubMed  Google Scholar 

  5. Spoerl E, Zubaty V, Raiskup-Wolf F, et al. Oestrogen-induced changes in biomechanics in the cornea as a possible reason for keratectasia. Br J Ophthalmol. 2007;91:1547–50.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Bilgihan K, Hondur A, Sul S, et al. Pregnancy-induced progression of keratoconus. Cornea. 2011;30:991–4.

    Article  PubMed  Google Scholar 

  7. Hafezi F, Iseli HP. Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking. J Cataract Refract Surg. 2008;34:1219–21.

    Article  PubMed  Google Scholar 

  8. Kappmeyer K, Lanzl IM. [Intra-ocular pressure during and after playing high and low resistance wind instruments]. Ophthalmologe. 2010;107:41–6.

    Google Scholar 

  9. McMonnies CW. The possible significance of the baropathic nature of keratectasias. Clin Exp Optom. 2013;96:197–200.

    Article  PubMed  Google Scholar 

  10. Kuo IC, Broman A, Pirouzmanesh A, et al. Is there an association between diabetes and keratoconus? Ophthalmology. 2006;113:184–90.

    Article  PubMed  Google Scholar 

  11. Seiler T, Huhle S, Spoerl E, et al. Manifest diabetes and keratoconus: a retrospective case-control study. Graefes Arch Clin Exp Ophthalmol. 2000;238:822–5.

    Article  CAS  PubMed  Google Scholar 

  12. Morita A. Tobacco smoke causes premature skin aging. J Dermatol Sci. 2007;48:169–75.

    Article  CAS  PubMed  Google Scholar 

  13. Mahmud A, Feely J. Effect of smoking on arterial stiffness and pulse pressure amplification. Hypertension. 2003;41:183–7.

    Article  CAS  PubMed  Google Scholar 

  14. Spoerl E, Raiskup-Wolf F, Kuhlisch E, et al. Cigarette smoking is negatively associated with keratoconus. J Refract Surg. 2008;24:S737–40.

    PubMed  Google Scholar 

  15. Vinciguerra P, Albe E, Trazza S, et al. Refractive, topographic, tomographic, and aberrometric analysis of keratoconic eyes undergoing corneal cross-linking. Ophthalmology. 2009;116:369–78.

    Article  PubMed  Google Scholar 

  16. Hersh PS, Greenstein SA, Fry KL. Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg. 2011;37:149–60.

    Article  PubMed  Google Scholar 

  17. Gomes JA, Tan D, Rapuano CJ, et al. Global consensus on keratoconus and ectatic diseases. Cornea. 2015;34:359–69.

    Article  PubMed  Google Scholar 

  18. Raiskup-Wolf F, Hoyer A, Spoerl E, et al. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796–801.

    Article  PubMed  Google Scholar 

  19. Wittig-Silva C, Chan E, Islam FM, et al. A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology. 2014;121:812–21.

    Article  PubMed  Google Scholar 

  20. O’Brart DP, Patel P, Lascaratos G, et al. Corneal cross-linking to halt the progression of keratoconus and corneal ectasia: seven-year follow-up. Am J Ophthalmol. 2015;160:1154–63.

    Article  PubMed  Google Scholar 

  21. Sharma N, Suri K, Sehra SV, et al. Collagen cross-linking in keratoconus in Asian eyes: visual, refractive and confocal microscopy outcomes in a prospective randomized controlled trial. Int Ophthalmol. 2015;35:827–32.

    Article  PubMed  Google Scholar 

  22. Lang SJ, Messmer EM, Geerling G, et al. Prospective, randomized, double-blind trial to investigate the efficacy and safety of corneal cross-linking to halt the progression of keratoconus. BMC Ophthalmol. 2015;15:78.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Kymionis GD, Portaliou DM, Bouzoukis DI, et al. Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg. 2007;33:1982–4.

    Article  PubMed  Google Scholar 

  24. Pollhammer M, Cursiefen C. Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A. J Cataract Refract Surg. 2009;35:588–9.

    Article  PubMed  Google Scholar 

  25. Rama P, Di Matteo F, Matuska S, et al. Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use. J Cataract Refract Surg. 2009;35:788–91.

    Article  PubMed  Google Scholar 

  26. Zamora KV, Males JJ. Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: a case report. Cornea. 2009;28:474–6.

    Article  PubMed  Google Scholar 

  27. Koller T, Mrochen M, Seiler T. Complication and failure rates after corneal crosslinking. J Cataract Refract Surg. 2009;35:1358–62.

    Article  PubMed  Google Scholar 

  28. Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea. 2006;25:1057–9.

    Article  PubMed  Google Scholar 

  29. Herrmann CI, Hammer T, Duncker GI. [Hazeformation (corneal scarring) after cross-linking therapy in keratoconus]. Ophthalmologe. 2008;105:485–7.

    Google Scholar 

  30. Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol. 2008;146:527–33.

    Article  CAS  PubMed  Google Scholar 

  31. Mazzotta C, Balestrazzi A, Baiocchi S, et al. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Exp Ophthalmol. 2007;35:580–2.

    Article  PubMed  Google Scholar 

  32. Greenstein SA, Fry KL, Bhatt J, et al. Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: Scheimpflug and biomicroscopic analysis. J Cataract Refract Surg. 2010;36:2105–14.

    Article  PubMed  Google Scholar 

  33. Raiskup F, Hoyer A, Spoerl E. Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg. 2009;25:S824–8.

    Article  PubMed  Google Scholar 

  34. Kymionis GD, Portaliou DM, Diakonis VF, et al. Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. Am J Ophthalmol. 2012;153:24–8.

    Article  CAS  PubMed  Google Scholar 

  35. Gokhale NS. Corneal endothelial damage after collagen cross-linking treatment. Cornea. 2011;30:1495–8.

    Article  PubMed  Google Scholar 

  36. Bagga B, Pahuja S, Murthy S, et al. Endothelial failure after collagen cross-linking with riboflavin and UV-A: case report with literature review. Cornea. 2012;31:1197–200.

    Article  PubMed  Google Scholar 

  37. Labiris G, Kaloghianni E, Koukoula S, et al. Corneal melting after collagen cross-linking for keratoconus: a case report. J Med Case Rep. 2011;5:152.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Gokhale NS, Vemuganti GK. Diclofenac-induced acute corneal melt after collagen crosslinking for keratoconus. Cornea. 2010;29:117–9.

    Article  PubMed  Google Scholar 

  39. Faschinger C, Kleinert R, Wedrich A. [Corneal melting in both eyes after simultaneous corneal cross-linking in a patient with keratoconus and Down syndrome]. Ophthalmologe. 2010;107:951–2, 954–5.

    Google Scholar 

  40. Eberwein P, Auw-Hadrich C, Birnbaum F, et al. [Corneal melting after cross-linking and deep lamellar keratoplasty in a keratoconus patient]. Klin Monbl Augenheilkd. 2008;225:96–8.

    Google Scholar 

  41. Sandvik GF, Thorsrud A, Raen M, et al. Does corneal collagen cross-linking reduce the need for keratoplasties in patients with keratoconus? Cornea. 2015;34:991–5.

    Article  PubMed  Google Scholar 

  42. Godefrooij DA, Gans R, Imhof SM, et al. Nationwide reduction in the number of corneal transplantations for keratoconus following the implementation of cross-linking. Acta Ophthalmol. 2016;94:675–8.

    Article  PubMed  Google Scholar 

  43. Rebenitsch RL, Kymes SM, Walline JJ, et al. The lifetime economic burden of keratoconus: a decision analysis using a Markov model. Am J Ophthalmol. 2011;151:768–73.e762.

    Article  PubMed  PubMed Central  Google Scholar 

  44. Salmon HA, Chalk D, Stein K, et al. Cost effectiveness of collagen crosslinking for progressive keratoconus in the UK NHS. Eye (Lond). 2015;29:1504–11.

    Article  CAS  Google Scholar 

  45. Craig JA, Mahon J, Yellowlees A, et al. Epithelium-off photochemical corneal collagen cross-linkage using riboflavin and ultraviolet a for keratoconus and keratectasia: a systematic review and meta-analysis. Ocul Surf. 2014;12(3):202–14.

    Article  PubMed  Google Scholar 

  46. Sykakis E, Karim R, Evans JR, et al. Corneal collagen cross-linking for treating keratoconus. Cochrane Database Syst Rev. 2015;(3):CD010621.

    Google Scholar 

  47. Pron G, Ieraci L, Kaulback K. Collagen cross-linking using riboflavin and ultraviolet-a for corneal thinning disorders: an evidence-based analysis. Ont Health Technol Assess Ser. 2011;11(5):1–89.

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Koppen C, Wouters K, Mathysen D, et al. Refractive and topographic results of benzalkonium chloride-assisted transepithelial crosslinking. J Cataract Refract Surg. 2012;38(6):1000–5.

    Article  PubMed  Google Scholar 

  49. Baiocchi S, Mazzotta C, Cerretani D, et al. Corneal crosslinking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg. 2009;35(5):893–9.

    Article  PubMed  Google Scholar 

  50. Spoerl E. Chapter 20: corneal collagen cross-linking: epithelium-on versus epithelium-off treatments. In: Hafezi F, Randleman JB, editors. Corneal collagen cross linking. Thorofare: SLACK Incorporated; 2013. p. 139–42.

    Google Scholar 

  51. Podskochy A. Protective role of corneal epithelium against ultraviolet radiation damage. Acta Ophthalmol Scand. 2004;82(6):714–7.

    Article  PubMed  Google Scholar 

  52. Wollensak G, Iomdina E. Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg. 2009;35(3):540–6.

    Article  PubMed  Google Scholar 

  53. Kissner A, Spoerl E, Jung R, et al. Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA/Riboflavin corneal collagen cross-linking. Curr Eye Res. 2010;35(8):715–21.

    Article  CAS  PubMed  Google Scholar 

  54. Raiskup F, Pinelli R, Spoerl E. Riboflavin osmolar modification for transepithelial corneal cross-linking. Curr Eye Res. 2012;37(3):234–8.

    Article  CAS  PubMed  Google Scholar 

  55. Scarcelli G, Kling S, Quijano E, et al. Brillouin microscopy of collagen crosslinking: noncontact depth-dependent analysis of corneal elastic modulus. Invest Ophthalmol Vis Sci. 2013;54(2):1418–25.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  56. Filippello M, Stagni E, O’Brart D. Transepithelial corneal collagen crosslinking: bilateral study. J Cataract Refract Surg. 2012;38(2):283–91.

    Article  PubMed  Google Scholar 

  57. Kocak I, Aydin A, Kaya F, et al. Comparison of transepithelial corneal collagen crosslinking with epithelium-off crosslinking in progressive keratoconus. J Fr Ophtalmol. 2014;37(5):371–6.

    Article  CAS  PubMed  Google Scholar 

  58. Caporossi A, Mazzotta C, Baiocchi S, et al. Riboflavin-UVA-induced corneal collagen cross-linking in pediatric patients. Cornea. 2012;31(3):227–31.

    Article  PubMed  Google Scholar 

  59. Al Fayez MF, Alfayez S, Alfayez Y. Transepithelial versus epithelium-off corneal collagen cross-linking for progressive keratoconus: a prospective randomized controlled trial. Cornea. 2015;34(Suppl 10):S53–6.

    Article  PubMed  Google Scholar 

  60. Soeters N, Wisse RPL, Godefrooij DA, et al. Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: a randomized controlled trial. Am J Ophthalmol. 2015;159(5):821–8.e3.

    Article  PubMed  Google Scholar 

  61. Gatzioufas Z, Raiskup F, O’Brart D, et al. Transepithelial corneal cross-linking using an enhanced riboflavin solution. J Refract Surg (Thorofare, N.J.: 1995). 2016;32(6):372–7.

    Article  Google Scholar 

  62. Yuksel E, Novruzlu S, Ozmen MC, et al. A study comparing standard and transepithelial collagen cross-linking riboflavin solutions: epithelial findings and pain scores. J Ocul Pharmacol Ther. 2015;31(5):296–302.

    Article  CAS  PubMed  Google Scholar 

  63. Caporossi A, Mazzotta C, Baiocchi S, et al. Transepithelial corneal collagen crosslinking for keratoconus: qualitative investigation by in vivo HRT II confocal analysis. Eur J Ophthalmol. 2012;22(Suppl 7):S81–8.

    Article  PubMed  Google Scholar 

  64. Mastropasqua L, Nubile M, Lanzini M, et al. Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy. Cornea. 2013;32(6):855–61.

    Article  PubMed  Google Scholar 

  65. Touboul D, Efron N, Smadja D, et al. Corneal confocal microscopy following conventional, transepithelial, and accelerated corneal collagen cross-linking procedures for keratoconus. J Refract Surg (Thorofare, N.J.: 1995). 2012;28(11):769–76.

    Article  Google Scholar 

  66. Bottos KM, Oliveira AG, Bersanetti PA, et al. Corneal absorption of a new riboflavin-nanostructured system for transepithelial collagen cross-linking. PLoS One. 2013;8(6):e66408.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Wollensak G, Hammer CM, Sporl E, et al. Biomechanical efficacy of collagen crosslinking in porcine cornea using a femtosecond laser pocket. Cornea. 2014;33(3):300–5.

    Article  PubMed  Google Scholar 

  68. Seiler TG, Fischinger I, Senfft T, et al. Intrastromal application of riboflavin for corneal crosslinking. Invest Ophthalmol Vis Sci. 2014;55(7):4261–5.

    Article  CAS  PubMed  Google Scholar 

  69. Kanellopoulos AJ. Collagen cross-linking in early keratoconus with riboflavin in a femtosecond laser-created pocket: initial clinical results. J Refract Surg (Thorofare, N.J.: 1995). 2009;25(11):1034–7.

    Article  Google Scholar 

  70. Yuksel E, Bektas C, Bilgihan K. Transepithelial versus epithelium-off corneal cross-linking for the treatment of progressive keratoconus: a randomized controlled trial. Am J Ophthalmol. 2015;160(2):399–400.

    Article  PubMed  Google Scholar 

  71. Lombardo M, Pucci G, Barberi R, et al. Interaction of ultraviolet light with the cornea: clinical implications for corneal crosslinking. J Cataract Refract Surg. 2015;41(2):446–59.

    Article  PubMed  Google Scholar 

  72. Cınar Y, Cingü AK, Türkcü FM, Çınar T, Yüksel H, Özkurt ZG, Çaça I. Comparison of accelerated and conventional corneal collagen cross-linking for progressive keratoconus. Cutan Ocul Toxicol. 2014;33(3):218–22.

    Article  PubMed  CAS  Google Scholar 

  73. Cınar Y, Cingü AK, Turkcu FM, Yüksel H, Sahin A, Yıldırım A, Caca I. Accelerated corneal collagen cross-linking for progressive keratoconus. Cutan Ocul Toxicol. 2014;33(2):168–71.

    Article  PubMed  CAS  Google Scholar 

  74. Legare ME, Iovieno A, Yeung SN, et al. Corneal collagen cross-linking using riboflavin and ultraviolet A for the treatment of mild to moderate keratoconus: 2-year follow-up. J Ophthalmol. 2013;48:63–8.

    Google Scholar 

  75. Kymionis GD, Tsoulnaras KI, Grentzelos MA, Liakopoulos DA, Tsakalis NG, Blazaki SV, Paraskevopoulos TA, Tsilimbaris MK. Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol. Am J Ophthalmol. 2014;158(4):671–5.

    Article  PubMed  Google Scholar 

  76. Shetty R, Nagaraja H, Jayadev C, Pahuja NK, Kurian Kummelil M, Nuijts RM. Accelerated corneal collagen cross-linking in pediatric patients: two-year follow-up results. Biomed Res Int. 2014;2014:894095.

    PubMed  PubMed Central  Google Scholar 

  77. Elbaz U, Shen C, Lichtinger A, Zauberman NA, Goldich Y, Chan CC, Slomovic AR, Rootman DS. Accelerated (9-mW/cm2) corneal collagen crosslinking for keratoconus-A 1-year follow-up. Cornea. 2014;33(8):769–73.

    Article  PubMed  Google Scholar 

  78. Jain V, Gazali Z, Bidayi R. Isotonic riboflavin and HPMC with accelerated cross-linking protocol. Cornea. 2014;33(9):910–3.

    Article  PubMed  Google Scholar 

  79. Pahuja N, Kumar NR, Francis M, Shanbagh S, Shetty R, Ghosh A, Roy AS. Correlation of clinical biomechanical outcomes of accelerated crosslinking (9 mW/cm2 in 10 minutes) in keratoconus with molecular expression of ectasia-related genes. Curr Eye Res. 2016;41(11):1419–23.

    Article  CAS  PubMed  Google Scholar 

  80. Marino GK, Torricelli AA, Giacomin N, Santhiago MR, Espindola R, Netto MV. Accelerated corneal collagen crosslinking for postoperative LASIK ectasia: two-year outcomes. J Refract Surg. 2015;31(6):380–4.

    Article  PubMed  Google Scholar 

  81. Sadoughi MM, Einollahi B, Baradaran-Rafii A, Roshandel D, Hasani H, Nazeri M. Accelerated versus conventional corneal collagen cross-linking in patients with keratoconus: an intrapatient comparative study. Int Ophthalmol. 2016. https://doi.org/10.1007/s10792-016-0423-0.

  82. Cingü AK, Sogutlu-Sari E, Cınar Y, Sahin M, Türkçü FM, Yüksel H, Sahin A, Caça I. Transient corneal endothelial changes following accelerated collagen cross-linking for the treatment of progressive keratoconus. Cutan Ocul Toxicol. 2014;33(2):127–31.

    Article  PubMed  CAS  Google Scholar 

  83. Hashemi H, Fotouhi A, Miraftab M, Bahrmandy H, Seyedian MA, Amanzadeh K, Heidarian S, Nikbin H, Asgari S. Short-term comparison of accelerated and standard methods of corneal collagen crosslinking. J Cataract Refract Surg. 2015;41(3):533–40.

    Article  PubMed  Google Scholar 

  84. Hashemi H, Miraftab M, Seyedian MA, Hafezi F, Bahrmandy H, Heidarian S, Amanzadeh K, Nikbin H, Fotouhi A, Asgari S. Long-term results of an accelerated corneal cross-linking protocol (18 mW/cm2) for the treatment of progressive keratoconus. Am J Ophthalmol. 2015;160(6):1164–70.

    Article  PubMed  Google Scholar 

  85. Chow VW, Chan TC, Yu M, Wong VW, Jhanji V. One year outcomes of conventional and accelerated collagen crosslinking in progressive keratoconus. Sci Rep. 2015;5:14425. https://doi.org/10.1038/srep14425.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Caporossi A, Mazzotta C, Baiocchi S, Caporossi T. Long-term results of riboflavin ultraviolet a corneal collagen crosslinking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol. 2010;149(4):585–93.

    Article  CAS  PubMed  Google Scholar 

  87. Asri D, Touboul D, Fournié P, Malet F, Garra C, Gallois A, Malecaze F, Colin J. Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus. J Cataract Refract Surg. 2011;37(12):2137–43.

    Article  PubMed  Google Scholar 

  88. Kanellopoulos AJ. Long term results of a prospective randomized bilateral eye comparison trial of higher fluence, shorter duration ultraviolet A radiation, and riboflavin collagen cross linking for progressive keratoconus. Clin Ophthalmol. 2012;6:97–101.

    Article  PubMed  PubMed Central  Google Scholar 

  89. Gatzioufas Z, Richoz O, Brugnoli E, Hafezi F. Safety profile of high-fluence corneal collagen cross-linking for progressive keratoconus: preliminary results from a prospective cohort study. J Refract Surg. 2013;29(12):846–8.

    Article  PubMed  Google Scholar 

  90. Wernli J, Schumacher S, Spoerl E, Mrochen M. The efficacy of corneal cross-linking shows a sudden decrease with very high intensity UV light and short treatment time. Invest Ophthalmol Vis Sci. 2013;54(2):1176–80.

    Article  PubMed  Google Scholar 

  91. Hammer A, Richoz O, Arba Mosquera S, Tabibian D, Hoogewoud F, Hafezi F. Corneal biomechanical properties at different corneal cross-linking (CXL) irradiances. Invest Ophthalmol Vis Sci. 2014;55(5):2881–4.

    Article  PubMed  Google Scholar 

  92. Chan TC, Chow VW, Jhanji V, Wong VW. Different topographic response between mild to moderate and advanced keratoconus after accelerated collagen cross-linking. Cornea. 2015;34(8):922–7.

    Article  PubMed  Google Scholar 

  93. Shetty R, Pahuja NK, Nuijts RM, Ajani A, Jayadev C, Sharma C, Nagaraja H. Current protocols of corneal collagen crosslinking—visual, refractive and tomographic outcomes. Am J Ophthalmol. 2015;160(2):243–9.

    Article  PubMed  Google Scholar 

  94. Kymionis GD, Tsoulnaras KI, Grentzelos MA, Plaka AD, Mikropoulos DG, Liakopoulos DA, Tsakalis NG, Pallikaris IG. Corneal stroma demarcation line after standard and high-intensity collagen crosslinking determined with anterior segment optical coherence tomography. J Cataract Refract Surg. 2014;40(5):736–40.

    Article  PubMed  Google Scholar 

  95. Kymionis GD, Grentzelos MA, Plaka AD, Tsoulnaras KI, Diakonis VF, Liakopoulos DA, Kankariya VP, Pallikaris AI. Correlation of the corneal collagen cross-linking demarcation line using confocal microscopy and anterior segment optical coherence tomography in keratoconic patients. Am J Ophthalmol. 2014;157(1):110–5.

    Article  PubMed  Google Scholar 

  96. Kurt T, Ozgurhan EB, Yildirim Y, Akcay BI, Cosar MG, Bozkurt E, Taskapili M. Accelerated (18mW/cm2) corneal cross-linking for progressive keratoconus: 18-month results. J Ocul Pharmacol Ther. 2016;32(4):186–91.

    Article  CAS  PubMed  Google Scholar 

  97. Razmjoo H, Peyman A, Rahimi A, Modrek HJ. Cornea collagen cross-linking for keratoconus: a comparison between accelerated and conventional methods. Adv Biomed Res. 2017;6:10.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Mazzotta C, Traversi C, Paradiso AL, Latronico ME, Rechichi M. Pulsed light accelerated crosslinking versus continuous light accelerated crosslinking: one-year results. J Ophthalmol. 2014;2014:604731.

    Article  PubMed  PubMed Central  Google Scholar 

  99. Merwald H, Klosner G, Kokesch C, Der-Petrossian M, Hönigsmann H, Trautinger F. UVA-induced oxidative damage and cytotoxicity depend on the mode of exposure. J Photochem Photobiol B. 2005;79(3):197–207.

    Article  CAS  PubMed  Google Scholar 

  100. Mazzotta C, Traversi C, Caragiuli S, Rechichi M. Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT. Eye (Lond). 2014;28(10):1179–83.

    Article  CAS  Google Scholar 

  101. Moramarco A, Iovieno A, Sartori A, Fontana L. Corneal stromal demarcation line after accelerated crosslinking using continuous and pulsed light. J Cataract Refract Surg. 2015;41(11):2546–51.

    Article  PubMed  Google Scholar 

  102. Ozgurhan EB, Kara N, Cankaya KI, Kurt T, Demirok A. Accelerated corneal cross-linking in pediatric patients with keratoconus: 24-month outcomes. J Refract Surg. 2014;30(12):843–9.

    Article  PubMed  Google Scholar 

  103. Ozgurhan EB, Akcay BI, Kurt T, Yildirim Y, Demirok A. Accelerated corneal collagen cross linking in thin keratoconic corneas. J Refract Surg. 2015;31(6):386–90.

    Article  PubMed  Google Scholar 

  104. Mita M, Waring GO 4th, Tomita M. High-irradiance accelerated collagen crosslinking for the treatment of keratoconus: six-month results. J Cataract Refract Surg. 2014;40(6):1032–40.

    Article  PubMed  Google Scholar 

  105. Spoerl E, Terai N, Scholz F, Raiskup F, Pillunat LE. Detection of biomechanical changes after corneal cross-linking using Ocular Response Analyzer software. J Refract Surg. 2011;27:452–7.

    Article  PubMed  Google Scholar 

  106. Mazzotta C, Caporossi T, Denaro R, Bovone C, Sparano C, Paradiso A, Baiocchi S, Caporossi A. Morphological and functional correlations in riboflavin UV A corneal collagen crosslinking for keratoconus. Acta Ophthalmol. 2012;90:259–65.

    Article  PubMed  Google Scholar 

  107. Tomita M, Mita M, Huseynova T. Accelerated versus conventional corneal collagen crosslinking. J Cataract Refract Surg. 2014;40(6):1013–20.

    Article  PubMed  Google Scholar 

  108. Sherif AM. Accelerated versus conventional corneal collagen cross-linking in the treatment of mild keratoconus: a comparative study. Clin Ophthalmol. 2014;8:1435–40.

    Article  PubMed  PubMed Central  Google Scholar 

  109. Beltaief O, Farah H, Kamoun R, Ben Said A, Ouertani A. Penetrating keratoplasty in children. Tunis Med. 2003;81(7):477–81.

    PubMed  Google Scholar 

  110. Reeves SW, Stinnett S, Adelman RA, et al. Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol. 2005;140:607–11.

    Article  PubMed  Google Scholar 

  111. Ertan A, Muftuoglu O. Keratoconus clinical findings according to different age and gender groups. Cornea. 2008;27(10):1109–13.

    Article  PubMed  Google Scholar 

  112. Al Suhaibani AH, Al-Rajhi AA, Al-Motowa S, Wagoner MD. Inverse relationship between age and severity and sequelae of acute corneal hydrops associated with keratoconus. Br J Ophthalmol. 2007;91(7):984–5.

    Article  PubMed  PubMed Central  Google Scholar 

  113. Leoni-Mesplie S, Mortemosque B, Touboul D, et al. Scalability and severity of keratoconus in children. Am J Ophthalmol. 2012;154:156–62.

    Article  Google Scholar 

  114. Chatzis N, Hafezi F, et al. Progression of keratoconus and efficacy of pediatric [corrected] corneal collagen cross-linking in children and adolescents. J Refract Surg. 2012;28(11):753–8.

    Article  PubMed  Google Scholar 

  115. Downie LE. The necessity for ocular assessment in atopic children: bilateral corneal hydrops in an 8 year-old. Pediatrics. 2014;134(2):e596–601.

    Article  PubMed  Google Scholar 

  116. Balasubramanian SA, Pye DC, Willcox MD. Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus. Clin Exp Optom. 2013;96:214–8.

    Article  PubMed  Google Scholar 

  117. Weed KH, MacEwen CJ, Giles T, Low J, McGhee CN. The Dundee University Scottish Keratoconus study: demographics, corneal signs, associated diseases, and eye rubbing. Eye (Lond). 2008;22:534–41.

    Article  CAS  Google Scholar 

  118. Wisse RP, Kuiper JJ, Gans R, Imhof S, Radstake TR, Van der Lelij A. Cytokine expression in keratoconus and its corneal microenvironment: a systematic review. Ocul Surf. 2015;13(4):272–83.

    Article  PubMed  Google Scholar 

  119. McMonnies CW. Inflammation and keratoconus. Optom Vis Sci. 2015;92(2):e35–41.

    Article  PubMed  Google Scholar 

  120. Godefrooij DA, Soeters N, Imhof SM, Wisse RP. Corneal cross-linking for pediatric keratoconus: long-term results. Cornea. 2016;35(7):954–8.

    Article  PubMed  Google Scholar 

  121. Vinciguerra P, Albé E, Frueh BE, Trazza S, Epstein D. Two-year corneal cross-linking results in patients younger than 18 years with documented progressive keratoconus. Am J Ophthalmol. 2012;154(3):520–6.

    Article  PubMed  Google Scholar 

  122. Raiskup F, Spoerl E. Corneal crosslinking with riboflavin and ultraviolet A. I. Principles. Ocul Surf. 2013;11(2):65–74.

    Article  PubMed  Google Scholar 

  123. Raiskup F, Spoerl E. Corneal crosslinking with riboflavin and ultraviolet A. Part II. Clinical indications and results. Ocul Surf. 2013;11(2):93–108.

    Article  PubMed  Google Scholar 

  124. Wollensak G, Spörl E, Mazzotta C, Kalinski T, Sel S. Interlamellar cohesion after corneal crosslinking using riboflavin and ultraviolet A light. Br J Ophthalmol. 2011;95(6):876–80.

    Article  CAS  PubMed  Google Scholar 

  125. Mazzotta C, Hafezi F, Kymionis G, Caragiuli S, Jacob S, Traversi C, Barabino S, Randleman JB. In vivo confocal microscopy after corneal collagen crosslinking. Ocul Surf. 2015;13(4):298–314.

    Article  PubMed  Google Scholar 

  126. Vinciguerra R, Romano MR, Camesasca FI, Azzolini C, Trazza S, Morenghi E, Vinciguerra P. Corneal cross-linking as a treatment for keratoconus: four-year morphologic and clinical outcomes with respect to patient age. Ophthalmology. 2013;120(5):908–16.

    Article  PubMed  Google Scholar 

  127. Magli A, Chiariello Vecchio E, Carelli R, et al. Pediatric keratoconus and iontophoretic corneal crosslinking: refractive and topographic evidence in patients underwent general and topical anesthesia, 18 months of follow-up. Int Ophthalmol. 2016;36(4):585–90.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Siena University, Ophthalmology Speciality School Siena University and Siena Crosslinking Center, Siena, Italy

    Cosimo Mazzotta

  2. Carl Gustav Carus University, Department of Ophthalmology Carl Gustav Carus University, Dresden, Germany

    Frederik Raiskup

  3. Siena University, Ophthalmology Speciality School Siena University, Siena, Italy

    Stefano Baiocchi & Claudio Traversi

  4. University of Maryland, Department of Bioengineering University of Maryland, College Park, Maryland, USA

    Giuliano Scarcelli

  5. Avedro, Waltham, Massachusetts, USA

    Marc D. Friedman

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  1. Cosimo Mazzotta
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  4. Giuliano Scarcelli
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  5. Marc D. Friedman
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  6. Claudio Traversi
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Mazzotta, C., Raiskup, F., Baiocchi, S., Scarcelli, G., Friedman, M.D., Traversi, C. (2017). Crosslinking Results and Literature Overview. In: Management of Early Progressive Corneal Ectasia. Springer, Cham. https://doi.org/10.1007/978-3-319-61137-2_2

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  • DOI: https://doi.org/10.1007/978-3-319-61137-2_2

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