Abstract
Non-round cell sarcomas may occur in children or young adolescents. We present some examples of the most common entities: epithelioid sarcoma, osteosarcoma; malignant peripheral nerve sheath tumor (MPNST), congenital infantile fibrosarcoma, and synovial sarcoma.
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References
Oda Y, Dal Cin P, Laskin WB. Epithelioid sarcoma. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumors of soft tissue and bone. Lyon: IARC Press; 2013. p. 216–8.
Chbani L, Guillou L, Terrier P, Decouvelaere AV, Grégoire F, Terrier-Lacombe MJ, et al. Epithelioid sarcoma: a clinicopathologic and immunohistochemical analysis of 106 cases from the French sarcoma group. Am J Clin Pathol. 2009;131:222–7.
Guillou L, Wadden C, Coindre JM, Krausz T, Fletcher CD. “Proximal-type” epithelioid sarcoma, a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study of a series. Am J Surg Pathol. 1997;21:130–46.
Modena P, Lualdi E, Facchinetti F, Galli L, Teixeira MR, Pilotti S, et al. Smarcb1/ini1 tumor suppressor gene is frequently inactivated in epithelioid sarcomas. Cancer Res. 2005;15:4012–9.
Niemann TH, Bottles K. Cytologic diagnosis of metastatic epithelioid sarcoma. A cytologic mimic of squamous cell carcinoma. Am J Clin Pathol. 1993;100:171–3.
Pohar-Marinšek Z, Zidar A. Epithelioid sarcoma in FNAB smears. Diagn Cytopathol. 1994;11:367–72.
Cardillo M, Zakowski MF, Lin O. Fine-needle aspiration of epithelioid sarcoma: cytology findings in nine cases. Cancer. 2001;93:246–51.
Zeppa P, Errico ME, Palombini L. Epithelioid sarcoma: report of two cases diagnosed by fine-needle aspiration biopsy with immunocytochemical correlation. Diagn Cytopathol. 1999;21:405–8.
Kitagawa Y, Ito H, Sawaizumi T, Matsubara M, Yokoyama M, Naito Z, et al. Fine needle aspiration cytology of primary epithelioid sarcoma. A report of 2 cases. Acta Cytol. 2004;48:391–6.
Lemos MM, Chaves P, Mendonça ME. Is preoperative cytologic diagnosis of epithelioid sarcoma possible? Diagn Cytopathol. 2008;36:780–6.
Barwad A, Dey P, Das A. Fine needle aspiration cytology of epithelioid sarcoma. Diagn Cytopathol. 2011;39:517–20.
Kulkarni MM, Deshmukh S, Patil V, Khandeparkar SG. Fine-needle aspiration cytology of recurrent epithelioid sarcoma of the foot: role of immonocytochemistry in definitive diagnosis. J Cytol. 2014;31:199–201.
Bajaj P, Aiyer H, Sinha BK, Jain M, Ashok S. Pitfalls in the diagnosis of epithelioid sarcoma presenting in an unusual site: a case report. Diagn Cytopathol. 2001;24:36–8.
Gonzalez-Peramato P, Jimenez-Heffernan JA, Cuevas J. Fine-needle aspiration cytology of “proximal-type” epithelioid sarcoma. Diagn Cytopathol. 2001;25:122–5.
Ikeda K, Tate G, Suzuki T, Mitsuya T. Fine needle aspiration cytology of primary proximal-type epithelioid sarcoma of the perineum: a case report. Acta Cytol. 2005;49:314–8.
Domanski HA, Akerman M. Fine-needle aspiration of primary osteosarcoma: a cytological-histological study. Diagn Cytopathol. 2005;32:269–75.
Barger A, Graca R, Bailey K, Messick J, de Lorimier LP, Fan T, et al. Use of alkaline phosphatase staining to differentiate canine osteosarcoma from other vimentin-positive tumors. Vet Pathol. 2005;42:161–5.
Akerman M, Berg NO, Persson BM. Fine needle aspiration biopsy in the evaluation of tumor-like lesions of bone. Acta Orthop Scand. 1976;47:129–36.
Rööser B, Herrlin K, Rydholm A, Akerman M. Pseudomalignant myositis ossificans. Clinical, radiologic, and cytologic diagnosis in 5 cases. Acta Orthop Scand. 1989;60:457–60.
Mokhtari M, Kumar PV, Rezazadeh S. Confusing cytological findings in myositis ossificans. Acta Cytol. 2012;56:565–70.
Sathiyamoorthy S, Ali SZ. Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration. Acta Cytol. 2012;56:481–6.
Klijanienko J, Caillaud JM, Orbach D, Brisse H, Lagacé R, Sastre-Gareau X. Cyto-histological correlations in primary, recurrent, and metastatic bone and soft tissue osteosarcoma. Institut Curie’s experience. Diagn Cytopathol. 2007;35(5):270.
Handa U, Bal A, Mohan H, Bhardwaj S. Fine needle aspiration cytology in the diagnosis of bone lesions. Cytopathology. 2005;16:59–64.
Soderlund V, Skoog L, Unni KK, Bertoni F, Brosjo O, Kreicbergs A. Diagnosis of high-grade osteosarcoma by radiology and cytology: a retrospective study of 52 cases. Sarcoma. 2004;8:31–6.
Dodd LG, Scully SP, Cothran RL, Harrelson JM. Utility of fine-needle aspiration in the diagnosis of primary osteosarcoma. Diagn Cytopathol. 2002;27:350–3.
Kilpatrick SE, Ward WG, Bos GD, Chauvenet AR, Gold SH. The role of fine needle aspiration biopsy in the diagnosis and management of osteosarcoma. Pediatr Pathol Mol Med. 2001;20:175–87.
Ward WG Sr, Kilpatrick S. Fine needle aspiration biopsy of primary bone tumors. Clin Orthop Relat Res. 2000;373:80–7.
Agarwal S, Agarwal T, Agarwal R, Agarwal PK, Jain UK. Fine needle aspiration of bone tumors. Cancer Detect Prev. 2000;24:602–9.
Nicol KK, Ward WG, Savage PD, Kilpatrick SE. Fine-needle aspiration biopsy of skeletal versus extraskeletal osteosarcoma. Cancer. 1998;84:176–85.
Collins BT, Cramer HM, Ramos RR. Fine needle aspiration biopsy of recurrent and metastatic osteosarcoma. Acta Cytol. 1998;42:357–61.
Willén H. Fine needle aspiration in the diagnosis of bone tumors. Acta Orthop Scand Suppl. 1997;273:47–53.
Kreicbergs A, Bauer HC, Brosjö O, Lindholm J, Skoog L, Söderlund V. Cytological diagnosis of bone tumours. J Bone Joint Surg Br. 1996;78:258–63.
Nanda M, Rao ES, Behera KC, Das S, Mohanty L. Fine needle aspiration cytology (FNAC) in malignant bone tumours. Indian J Pathol Microbiol. 1994;37:247–53.
Jayaram G, Gupta M. Fine needle aspiration cytology in the diagnosis of bone tumours. Malays J Pathol. 1994;16:137–44.
Kumar RV, Rao CR, Hazarika D, Mukherjee G, Gowda BM. Aspiration biopsy cytology of primary bone lesions. Acta Cytol. 1993;37:83–9.
Walaas L, Kindblom LG. Light and electron microscopic examination of fine-needle aspirates in the preoperative diagnosis of osteogenic tumors: a study of 21 osteosarcomas and two osteoblastomas. Diagn Cytopathol. 1990;6:27–38.
White VA, Fanning CV, Ayala AG, Raymond AK, Carrasco CH, Murray JA. Osteosarcoma and the role of fine-needle aspiration. A study of 51 cases. Cancer. 1988;62:1238–46.
Layfield LJ, Glasgow BJ, Anders KH, Mirra JM. Fine needle aspiration cytology of primary bone lesions. Acta Cytol. 1987;31:177–84.
Peng XJ, Yan XC. Cytodiagnosis of bone tumors by fine needle aspiration. Acta Cytol. 1985;29:570–5.
Nielsen GP, Antonescu CR, Lothe RA. Malignant peripheral nerve sheath tumour. In: Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. WHO classification of tumours of soft tissue and bone. Fourth edition. Lyon: IARC; 2012. p. 157–9.
Klijanienko J, Caillaud JM, Lagacé R, Vielh P. Cytohistologic correlations of 24 malignant peripheral nerve sheath tumor (MPNST) in 17 patients: the Institut Curie experience. Diagn Cytopathol. 2002;27:103–8.
Wakely PE Jr, Ali SZ, Bishop JA. The cytopathology of malignant peripheral nerve sheath tumor: a report of 55 fine-needle aspiration cases. Cancer Cytopathol. 2012;120:334–41.
Gupta K, Dey P, Vashisht R. Fine-needle aspiration cytology of malignant peripheral nerve sheath tumors. Diagn Cytopathol. 2004;31:1–4.
Rao A, Ingle SB, Rajurkar P, Goyal V, Dokrimare N. Malignant peripheral nerve sheath tumor of proximal third tibia. World J Clin Oncol. 2015;6:179–83.
Chebib I, Hornicek FJ, Nielsen GP, Deshpande V. Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions. Cancer Cytopathol. 2015;123:171–9.
Klijanienko J, Caillaud JM, Lagacé R. Cytohistologic correlations in schwannomas (neurilemmomas), including “ancient,” cellular, and epithelioid variants. Diagn Cytopathol. 2006;34:517–22.
Klijanienko J, Caillaud JM, Lagacé R, Vielh P. Cytohistologic correlations in 56 synovial sarcomas in 36 patients: the Institut Curie experience. Diagn Cytopathol. 2002;27:96–102.
Klijanienko J, Caillaud JM, Lagacé R. Fine-needle aspiration of primary and recurrent dermatofibrosarcoma protuberans. Diagn Cytopathol. 2004;30:261–5.
Klijanienko J, Caillaud JM, Orbach D, Brisse H, Lagacé R, Vielh P, et al. Cyto-histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: the institut Curie’s experience. Diagn Cytopathol. 2007;35:482–7.
Pavlick D, Schrock AB, Malicki D, Stephens PJ, Kuo DJ, Ahn H, et al. Identification of NTRK fusions in pediatric mesenchymal tumors. Pediatr Blood Cancer. 2017; https://doi.org/10.1002/pbc.26433.
Knezevich SR, McFadden DE, Tao W, Lim JF, Sorensen PH. A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184–7.
El Demellawy D, Cundiff CA, Nasr A, Ozolek JA, Elawabdeh N, Caltharp SA, et al. Congenital mesoblastic nephroma: a study of 19 cases using immunohistochemistry and ETV6-NTRK3 fusion gene rearrangement. Pathology. 2016;48:47–50.
Layfield LJ, Bedrossian CW, Crim JR, Palombini L. Spindle cell tumors of bone and soft tissue in infants and children. In:Musculoskeletal cytohistology, Cytohistology of small tissue samples. New York: Cambridge University Press; 2012. p. 30–2.
Akerman M, Domanski HA. The cytology of soft tissue tumours. Monogr Clin Cytol. 2003;16:IX–X; 1–112.
Domanski HA, Qian X, Åkerman M, Stanley DE. Fibroblastic/myofibroblastic tumors. In: Domanski HA, editor. Atlas of fine needle aspiration cytology. London: Springer-Verlag; 2014. p. 405–6.
Köse D, Annagür A, Erol C, Uğraş S, Köksal Y. Synovial sarcoma in a premature newborn. Pediatr Int. 2014;56:17–20.
Radhakrishnan V, Joel A, Sundersingh S, Raja A. Synovial sarcoma in a neonate. Indian Pediatr. 2016;53:345–6.
Bhattacharya D, Datta S, Das A, Halder KC, Chattopadhyay S. Primary pulmonary synovial sarcoma: a case report and review of literature. Int J Appl Basic Med Res. 2016;6:63–5.
Huang CC, Michael CW, Pang JC. Fine needle aspiration of primary mediastinal synovial sarcoma: cytomorphologic, immunohistochemical, and molecular study. Diagn Cytopathol. 2014;42:170–6.
Pal M, Ghosh BN, Roy C, Manna AK. Posterior mediastinal biphasic synovial sarcoma in a 12 year-old boy: a case report and review of literature. J Cancer Res Ther. 2010;6:564–6.
Murro D, Slade JM, Syed S, Gattuso P. Fine needle aspiration of secondary synovial sarcoma of the thyroid gland. Diagn Cytopathol. 2015;43:928–32.
Akerman M, Domanski HA. The complex cytological features of synovial sarcoma in fine needle aspirates, an analysis of four illustrative cases. Cytopathology. 2007;18:234–40.
Akerman M, Ryd W, Skytting B, Scandinavian Sarcoma Group. Fine-needle aspiration of synovial sarcoma: criteria for diagnosis: retrospective reexamination of 37 cases, including ancillary diagnostics. A Scandinavian Sarcoma Group study. Diagn Cytopathol. 2003;28:232–8.
Srinivasan R, Gautam U, Gupta R, Rajwanshi A, Vasistha RK. Synovial sarcoma: diagnosis on fine-needle aspiration by morphology and molecular analysis. Cancer. 2009;117:128–36.
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Domanski, H.A., Klijanienko, J. (2018). Non-round Cell Sarcomas. In: Klijanienko, J., Pohar Marinšek, Ž., Domanski, H. (eds) Small Volume Biopsy in Pediatric Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-61027-6_6
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DOI: https://doi.org/10.1007/978-3-319-61027-6_6
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