Skip to main content

Probiotics and Infection Prevention

  • Chapter
  • First Online:
Infection Prevention
  • 2253 Accesses

Abstract

Increasing interest in the clinical use of probiotics in the United States is driven both by consumer enthusiasm for products marketed to have potential health benefits and by researchers inspired by the potential to prevent, treat, and mitigate disease. A limited number of studies have examined the use of probiotics as a potential tool in the antimicrobial resistance crisis. These studies include trials using probiotics to eliminate vancomycin-resistant Enterococcus colonization and to prevent multidrug-resistant organisms. These topics, along with the safety of probiotics in the healthcare setting, will be discussed in detail in this chapter. Results have been mixed, leading to ongoing controversy regarding the utility of probiotics in these settings. The conversation is limited by the quality of published studies. Specifically, there is an overall lack of uniformity in nearly all elements of study design which makes generalizability of results difficult for clinicians.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Guarner F, Schaafsma GJ. Probiotics. Int J Food Microbiol. 1998;39:237–8.

    Article  CAS  PubMed  Google Scholar 

  2. World Health Organization. Report on the burden of endemic health care-associated infection worldwide: a systematic review of the literature. apps.who.int . [Online] 2011. http://apps.who.int/iris/bitstream/10665/80135/1/9789241501507_eng.pdf

  3. Vandenberg PA. Lactic acid bacteria, their metabolic products and interference with microbial growth. FEMS Microbiol Rev. 1993;12:221–38.

    Article  Google Scholar 

  4. Silva M, Jacobus NV, Deneke C, Gorbach SL. Antimicrobial substance from a human lactobacillus strain. Antimicrob Agents Chemother. 1987;31:1231–3.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Axelsson LT, Chung TC, Dobrogosz WJ, Lindgren SE. Production of a broad spectrum antimicrobial substance by Lactobacillus reuteri. Microb Ecol Health Dis. 1989;2:131–6.

    Article  Google Scholar 

  6. Coconnier MH, et al. Inhibition of adhesion on enteroinvasive pathogens to human intestinal Caco-2 cells by lactobacillus acidophilus strain LB decreases bacterial invasion. FEMS Microbiol Lett. 1993;110:299–306.

    Article  CAS  PubMed  Google Scholar 

  7. Mack DR, Michail S, Weis, et al. Probiotic inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression. Am J Phys. 1999;276:G–941.

    Google Scholar 

  8. Chan RCY, Rei G, Irvin RT, Bruce AW, Costerton JW. Competitive exclusion of uropathogens from uroepithelial cells by Lactobacillus whole cells and cell wall fragments. Infect Immun. 1985;1985:84–9.

    Google Scholar 

  9. Murray BE. Vancomycin-resistant enterococcal infections. N Engl J Med. 2000;342:710–21.

    Article  CAS  PubMed  Google Scholar 

  10. Vergis EN, et al. Determinants of vancomycin resistance and mortality rates in enterococcal bacteremia. A prospective multicenter study. Ann Intern Med. 2001;135:484–92.

    Article  CAS  PubMed  Google Scholar 

  11. Manley KJ, Fraenkel MB, Mayall BC, Power DA. Probiotic treatment of vancomycin-resistant enterococci: a randomised controlled trial. Med J Aust. 2007;186:454–7.

    PubMed  Google Scholar 

  12. Szachta P, Ignys I, Cichy W. An evaluation of the ability of the probiotic strain Lactobacillus rhamnosus GG to eliminate the gastrointestinal carrier state of vancomycin-resistant enterococci in colonized children. J Clin Gastroenterol. 2011;45:872–7.

    Article  PubMed  Google Scholar 

  13. Doron S, Hibberd PL, Goldin B, Thorpe C, McDermott L, Snydman DR. Effect of Lactobacillus rhamnosus GG administration on vancomycin-resistant enterococcus colonization in adults with comorbidities. Antimicrob Agents Chemother. 2015;59:4593–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Goldin BR, Gorbach SL, Saxelin M, Barakat S, Gualtieri L, Salminen S. Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci. 1992;37:121–8.

    Article  CAS  PubMed  Google Scholar 

  15. Kwon JH, Bommarito KM, Reske KA, et al. Randomized controlled trial to determine the impact of probiotic administration on colonization with multidrug-resistant organisms in critically Ill patients. Infect Contr Hosp Epidemiol. 2015;36(12):1451–54.

    Google Scholar 

  16. Barraud D, Bolleart PE, Gibot S. Impact of the administration of probiotics on mortality in critically ill patients. Chest. 2013;143:646–55.

    Article  PubMed  Google Scholar 

  17. Petrof E, et al. Probiotics in the critically ill: a systematic review of the randomized trial evidence. Crit Care Med. 2012;40:3290–302.

    Article  PubMed  Google Scholar 

  18. Doron S, Snydman DR. Risk and safety of probiotics. Clin Infect Dis. 2015;60(Suppl 2):S129–34.

    Google Scholar 

  19. U.S. Department of Health and Human Services, Food and Drug Administration. Guidance for clinical investigators, sponsors, and IRBs: Investigational New Drug Applications (INDs)—determining whether human research studies can be conducted without an IND. n.d.. www.fda.gov. [Online] September 2013. http://www.fda.gov/downloads/Drugs/Guidances/UCM229175.pdf.

  20. Hempel S, Newberry S, Ruelaz A, et al. Safety of probiotics used to reduce risk and prevent or treat disease. Rockville: Agency for Healthcare Resarch and Quality; 2011.

    Google Scholar 

  21. Besselink MG, van Santvoort HC, Buskens HC, Boermeester MA, van Goor H, Timmerman HM, Nieuwenhuijs VB, Bollen TL, van Ramshorst B, Witteman BJ, Rosman C, Ploeg RJ, Brink MA, Schaapherder AF, Dejong CH, Wahab PJ, van Laarhoven CJ, van der Harst E, van Eijck CH, Cuesta MA, Akkermans LM, Gooszen HG, Dutch Acute Pancreatitis Study Group. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double blind controlled trial. Lancet. 2008;371:651–9.

    Article  PubMed  Google Scholar 

  22. Olah A, Belagyi T, Issekutz A, Gamal ME, Bengmark S. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br J Surg. 2002;89:1103–7.

    Article  CAS  PubMed  Google Scholar 

  23. Inspectie voor de Gezondheiszorg, Centrale Commissie Mensgebonden Onderzoek en Voedsel en Waren Autoriteit. Den Haag/Utrect. [Online] 2009. http://www.igz.nl/actueel/nieuws/belangrijketekortkomingenpropatriastudieverbeteringenvoorverantwoordklinischonderzoeknoodzakelijk.aspx

  24. Hoojimans CR, De Vries RBM, Rovers MM, Gooszen HG, Ritskes-Hoitinga M. The effects of probiotic supplementation on experimental acute pancreatitis: a systematic review and meta-analysis. PLoS One. 2012;7:e48811.

    Article  Google Scholar 

  25. Gou S, Yang Z, Liu T, Wu H, Wang C. Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials. Crit Care. 2014;18:R 57.

    Article  Google Scholar 

  26. Bongaerts GPA, Severijnen RVM. A reassessment of the PROPATRIA study and its implications for probiotic therapy. Nat Biotechnol. 2016;34:55–63.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Whitney Perry .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Perry, W., Doron, S. (2018). Probiotics and Infection Prevention. In: Bearman, G., Munoz-Price, S., Morgan, D., Murthy, R. (eds) Infection Prevention. Springer, Cham. https://doi.org/10.1007/978-3-319-60980-5_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-60980-5_22

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60978-2

  • Online ISBN: 978-3-319-60980-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics