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Multispectral Biopsy Image Based Colorectal Tumor Grader

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Medical Image Understanding and Analysis (MIUA 2017)

Part of the book series: Communications in Computer and Information Science ((CCIS,volume 723))

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Abstract

Automated tumor cell grading systems have an immense potential in improving the speed and accuracy of cancer diagnostic procedures. It can boost the confidence level of pathologists who perform the manual assessment of tumor cells. The application of image processing and machine learning techniques on the digitized biopsy slides enables the discrimination between various cell types. Deployment of multispectral imaging technique for biopsy slide digitization serves to provide spectral information along with the spatial information. Multispectral imaging allows to acquire several images of the sample in multiple wavelengths including the infrared ranges. This paper presents a multispectral image based colorectal tumor grading system. The algorithm validation is performed on our biopsy image database comprising 200 samples from 4 classes, viz. normal, hyperplastic polyp, tubular adenoma low grade as well as carcinoma cells. In addition to the visible bands, we have incorporated the spectral bands in near infrared ranges. Rotation invariant Local phase quantization (LPQ) feature extraction on our multispectral images have yielded a classification accuracy of 86.05% with an SVM classifier. Moreover, the experiments were carried out on another small multispectral image dataset which had 3 categories of cells.

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Notes

  1. 1.

    http://imaging.qu.edu.qa/datasets/.

References

  1. American Cancer Society. http://old.cancer.org/cancer/colonandrectumcancer/index

  2. The Lancet Oncology: Addressing the burden of cancer in the Gulf. Lancet Oncol. 15(13), 1407, 2045(14), 71141–71146 (2014). Epub 24 November 2014

    Google Scholar 

  3. Siegel, R.L., Miller, K.D., Jemal, A.: Cancer statistics. CA Cancer J. Clin. 66(1), 7–30 (2016)

    Article  Google Scholar 

  4. Kunhoth, S., Al Maadeed, S., Bouridane, A., Al, S.R.: Medical and computing insights into colorectal tumors. Int. J. Life Sci. Biotechnol. Pharma Res. 4(2), 122 (2015)

    Google Scholar 

  5. Turner, J.K., Williams, G.T., Morgan, M., Wright, M., Dolwani, S.: Interobserver agreement in the reporting of colorectal polyp pathology among bowel cancer screening pathologists in Wales. Histopathology 62(6), 916–924 (2013)

    Article  Google Scholar 

  6. Rathore, S., Hussain, M., Ali, A., Khan, A.: A recent survey on colon cancer detection techniques. IEEE/ACM Trans. Comput. Biol. Bioinform. 10(3), 545–563 (2013)

    Article  Google Scholar 

  7. Boucheron, L.E., Bi, Z., Harvey, N.R., Manjunath, B., Rimm, D.L.: Utility of multispectral imaging for nuclear classification of routine clinical histopathology imagery. BMC Cell Biol. 8(1), 1 (2007)

    Article  Google Scholar 

  8. Zhang, J., Liu, Y.: Cervical cancer detection using SVM based feature screening. In: Barillot, C., Haynor, David R., Hellier, P. (eds.) MICCAI 2004. LNCS, vol. 3217, pp. 873–880. Springer, Heidelberg (2004). doi:10.1007/978-3-540-30136-3_106

    Chapter  Google Scholar 

  9. Roula, M., Diamond, J., Bouridane, A., Miller, P., Amira, A.: A multispectral computer vision system for automatic grading of prostatic neoplasia. In: Proceedings 2002 IEEE International Symposium on Biomedical Imaging. IEEE (2002)

    Google Scholar 

  10. Tahir, M.A., Bouridane, A., Kurugollu, F., Amira, A.: A novel prostate cancer classification technique using intermediate memory tabu search. EURASIP J. Adv. Sig. Process. 2005(14), 1–9 (2005)

    MATH  Google Scholar 

  11. Tahir, M.A., Bouridane, A.: Novel round-robin tabu search algorithm for prostate cancer classification and diagnosis using multispectral imagery. IEEE Trans. Inf Technol. Biomed. 10(4), 782–793 (2006)

    Article  Google Scholar 

  12. Tahir, M.A., Bouridane, A., Roula, M.A.: Prostate cancer classification using multispectral imagery and metaheuristics. Comput. Intell. Med. Imaging: Tech. Appl., 139 (2009)

    Google Scholar 

  13. Bouatmane, S., Roula, M.A., Bouridane, A., Al-Maadeed, S.: Round-Robin sequential forward selection algorithm for prostate cancer classification and diagnosis using multispectral imagery. Mach. Vis. Appl. 22(5), 865–878 (2011)

    Article  Google Scholar 

  14. Khelifi, R., Adel, M., Bourennane, S.: Multispectral texture characterization: application to computer aided diagnosis on prostatic tissue images. EURASIP J. Adv. Sig. Process. 2012(1), 1 (2012)

    Article  Google Scholar 

  15. Rajpoot, K., Rajpoot, N.: SVM optimization for hyperspectral colon tissue cell classification. In: Barillot, C., Haynor, David R., Hellier, P. (eds.) MICCAI 2004. LNCS, vol. 3217, pp. 829–837. Springer, Heidelberg (2004). doi:10.1007/978-3-540-30136-3_101

    Chapter  Google Scholar 

  16. Masood, K., Rajpoot, N.M., Qureshi, H.A., Rajpoot, K.: Co-occurrence and morphological analysis for colon tissue biopsy classification (2006)

    Google Scholar 

  17. Masood, K., Rajpoot, N.M.: Classification of colon biopsy samples by spatial analysis of a single spectral band from its hyperspectral cube (2007)

    Google Scholar 

  18. Masood, K., Rajpoot, N.: Texture based classification of hyperspectral colon biopsy samples using CLBP. In: 2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro. IEEE (2009)

    Google Scholar 

  19. Maggioni, M., Davis, G.L., Warner, F.J., Geshwind, F.B., Coppi, A.C., DeVerse, R.A., et al.: Hyperspectral microscopic analysis of normal, benign and carcinoma microarray tissue sections. Biomedical Optics 2006; International Society for Optics and Photonics (2006)

    Google Scholar 

  20. Chaddad, A., Tanougast, C., Dandache, A., Al Houseini, A., Bouridane, A.: Improving of colon cancer cells detection based on Haralick’s features on segmented histopathological images. In: 2011 IEEE International Conference on Computer Applications and Industrial Electronics (ICCAIE). IEEE (2011)

    Google Scholar 

  21. Chaddad, A., Tanougast, C., Dandache, A., Bouridane, A.: Extracted haralick’s texture features and morphological parameters from segmented multispectrale texture bio-images for classification of colon cancer cells. WSEAS Trans. Biol/Biomed. 8(2), 39–50 (2011)

    Google Scholar 

  22. Chaddad, A., Tanougast, C., Golato, A., Dandache, A.: Carcinoma cell identification via optical microscopy and shape feature analysis. J. Biomed. Sci. Eng. 6(11), 1029 (2013)

    Article  Google Scholar 

  23. Chaddad, A., Desrosiers, C., Bouridane, A., Toews, M., Hassan, L., Tanougast, C.: Multi texture analysis of colorectal cancer continuum using multispectral imagery. PLoS ONE 11(2), e0149893 (2016)

    Article  Google Scholar 

  24. Oranit, B., Chamidu, A., Hiroshi, N., Kota, A., Fumikazu, K., Masahiro, Y.: Multispectral band analysis: application on the classification of hepatocellular carcinoma cells in high-magnification histopathological images. J. Cytol. Histol. 3(3), 1 (2015)

    Google Scholar 

  25. Qi, X., Xing, F., Foran, D.J., Yang, L.: Comparative performance analysis of stained histopathology specimens using RGB and multispectral imaging. In: SPIE Medical Imaging. International Society for Optics and Photonics (2011)

    Google Scholar 

  26. Peyret, R., Bouridane, A., Al-Maadeed, S.A., Kunhoth, S., Khelifi, F.: Texture analysis for colorectal tumour biopsies using multispectral imagery. In: 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE (2015)

    Google Scholar 

  27. Zimmerman-Moreno, G., Marin, I., Lindner, M., Barshack, I., Garini, Y., Konen, E., et al.: Automatic classification of cancer cells in multispectral microscopic images of lymph node samples. In: 2016 IEEE 38th Annual International Conference of the Engineering in Medicine and Biology Society (EMBC). IEEE (2016)

    Google Scholar 

  28. Ojansivu, V., Heikkilä, J.: Blur insensitive texture classification using local phase quantization. In: Elmoataz, A., Lezoray, O., Nouboud, F., Mammass, D. (eds.) ICISP 2008. LNCS, vol. 5099, pp. 236–243. Springer, Heidelberg (2008). doi:10.1007/978-3-540-69905-7_27

    Chapter  Google Scholar 

  29. Ojala, T., Pietikäinen, M., Harwood, D.: A comparative study of texture measures with classification based on featured distributions. Pattern Recogn. 29(1), 51–59 (1996)

    Article  Google Scholar 

  30. Ojansivu, V., Rahtu, E., Heikkila, J.: Rotation invariant local phase quantization for blur insensitive texture analysis. In: 19th International Conference on Pattern Recognition, ICPR 2008. IEEE (2008)

    Google Scholar 

  31. Ojala, T., Pietikainen, M., Maenpaa, T.: Multiresolution gray-scale and rotation invariant texture classification with local binary patterns. IEEE Trans. Pattern Anal. Mach. Intell. 24(7), 971–987 (2002)

    Article  MATH  Google Scholar 

  32. Scholkopf, B., Smola, A.J.: Learning with Kernels: Support Vector Machines, Regularization, Optimization, and Beyond. MIT press, Cambridge (2001)

    Google Scholar 

  33. Genuer, R., Poggi, J., Tuleau-Malot, C.: Variable selection using random forests. Pattern Recog. Lett. 31(14), 2225–2236 (2010)

    Article  Google Scholar 

  34. Chang, C., Lin, C.: LIBSVM: a library for support vector machines. ACM Trans. Intell. Syst. Technol. (TIST) 2(3), 27 (2011)

    Google Scholar 

  35. Kuncheva LI. Combining pattern classifiers: methods and algorithms. John Wiley & Sons; 2004

    Google Scholar 

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Acknowledgment

This publication was made possible using a grant from the Qatar National Research Fund through National Priority Research Program (NPRP) No. 6-249-1-053. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the Qatar National Research Fund or Qatar University.

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Correspondence to Suchithra Kunhoth .

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Kunhoth, S., Al Maadeed, S. (2017). Multispectral Biopsy Image Based Colorectal Tumor Grader. In: Valdés Hernández, M., González-Castro, V. (eds) Medical Image Understanding and Analysis. MIUA 2017. Communications in Computer and Information Science, vol 723. Springer, Cham. https://doi.org/10.1007/978-3-319-60964-5_29

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  • DOI: https://doi.org/10.1007/978-3-319-60964-5_29

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