Abstract
Embolic and haemodynamic events constitute the main neurological complication during anaesthesia and postoperative period. Ischaemic stroke after major cardiac and vascular surgeries is well described. Conversely, such occurrence seems rare but more insidious in the context of general surgeries. Prevention should start with identification of high-risk patients for perioperative stroke with potential modifiable factors. Then the perioperative strategy should be adapted to individuals. Those patients might benefit from the development of personalized perioperative medicine.
Other patients with chronic disorders like epilepsy, or neurodegenerative diseases (i.e. Alzheimer’s or Parkinson’s), or ageing patients will preferentially present delirium or postoperative cognitive decline and acute clinical deterioration after surgery. These adverse events seem associated with unfavourable outcome. The impact of anaesthetic strategy on the course of the disease remains debated. Future clinical investigations might propose suitable anaesthetic strategy for those patients.
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Mashour GA, et al. Perioperative care of patients at high risk for stroke during or after non-cardiac, non-neurologic surgery: consensus statement from the Society for Neuroscience in Anesthesiology and Critical Care. J Neurosurg Anesthesiol. 2014;26(4):273–85. http://www.ncbi.nlm.nih.gov/pubmed/24978064. Accessed 25 July 2016.
Bucerius J, et al. Stroke after cardiac surgery: a risk factor analysis of 16,184 consecutive adult patients. Ann Thorac Surg. 2003;75(2):472–8. http://www.ncbi.nlm.nih.gov/pubmed/12607656. Accessed 25 July 2016.
Messé SR, et al. Stroke after aortic valve surgery: results from a prospective cohort. Circulation. 2014;129(22):2253–61. http://www.ncbi.nlm.nih.gov/pubmed/24690611. Accessed 27 July 2016.
Bateman BT, et al. Perioperative acute ischemic stroke in noncardiac and nonvascular surgery: incidence, risk factors, and outcomes. Anesthesiology. 2009;110(2):231–8. http://www.ncbi.nlm.nih.gov/pubmed/19194149. Accessed 25 July 2016.
Mashour GA, Shanks AM, Kheterpal S. Perioperative stroke and associated mortality after noncardiac, nonneurologic surgery. Anesthesiology. 2011;114(6):1289–96. http://www.ncbi.nlm.nih.gov/pubmed/21478735. Accessed 25 July 2016.
Barber PA, et al. Cerebral ischemic lesions on diffusion-weighted imaging are associated with neurocognitive decline after cardiac surgery. Stroke. 2008;39(5):1427–33. http://www.ncbi.nlm.nih.gov/pubmed/18323490. Accessed 25 July 2016.
Biteker M, et al. Impact of perioperative acute ischemic stroke on the outcomes of noncardiac and nonvascular surgery: a single centre prospective study. Can J Surg. 2014;57(3):E55–61.
Urbanek C, et al. Recent surgery or invasive procedures and the risk of stroke. Cerebrovasc Dis. 2014;38(5):370–6. http://www.ncbi.nlm.nih.gov/pubmed/25427844. Accessed 27 July 2016.
POISE Study Group, et al. Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet. 2008;371(9627):1839–47.
Berwanger O, et al. Association between pre-operative statin use and major cardiovascular complications among patients undergoing non-cardiac surgery: the VISION study. Eur Heart J. 2016;37(2):177–85. http://www.ncbi.nlm.nih.gov/pubmed/26330424. Accessed 27 July 2016.
de Waal BA, Buise MP, van Zundert AAJ. Perioperative statin therapy in patients at high risk for cardiovascular morbidity undergoing surgery: a review. Br J Anaesth. 2015;114(1):44–52. http://www.ncbi.nlm.nih.gov/pubmed/25186819. Accessed 27 July 2016.
Saltman AP, et al. Care and outcomes of patients with in-hospital stroke. JAMA Neurology. 2015;72(7):749–55. http://www.ncbi.nlm.nih.gov/pubmed/25938195. Accessed 25 July 2016.
Nielsen HB. Systematic review of near-infrared spectroscopy determined cerebral oxygenation during non-cardiac surgery. Front Physiol. 2014;5:93. http://www.ncbi.nlm.nih.gov/pubmed/24672486. Accessed 29 July 2016.
Drummond JC. The lower limit of autoregulation: time to revise our thinking? Anesthesiology. 1997;86(6):1431–3. http://www.ncbi.nlm.nih.gov/pubmed/9197320. Accessed 28 July 2016.
Willie CK, et al. Integrative regulation of human brain blood flow. J Physiol. 2014;592(5):841–59. http://www.ncbi.nlm.nih.gov/pubmed/24396059. Accessed 28 July 2016.
Hirsch J, et al. Impact of intraoperative hypotension and blood pressure fluctuations on early postoperative delirium after non-cardiac surgery. Br J Anaesth. 2015;115(3):418–26. http://www.ncbi.nlm.nih.gov/pubmed/25616677. Accessed 28 July 2016.
Meng L, et al. Cardiac output and cerebral blood flow: the integrated regulation of brain perfusion in adult humans. Anesthesiology. 2015;123(5):1198–208. http://www.ncbi.nlm.nih.gov/pubmed/26402848. Accessed 28 July 2016.
Meng L, Gelb AW. Regulation of cerebral autoregulation by carbon dioxide. Anesthesiology. 2015;122(1):196–205. http://www.ncbi.nlm.nih.gov/pubmed/25401418. Accessed 28 July 2016.
TOOLE JF, TUCKER SH. Influence of head position upon cerebral circulation. Studies on blood flow in cadavers. Arch Neurol. 1960;2:616–23. http://www.ncbi.nlm.nih.gov/pubmed/13838838. Accessed 28 July 2016.
Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. N Engl J Med. 2009;360(12):1226–37. http://www.ncbi.nlm.nih.gov/pubmed/19297575. Accessed 26 July 2016.
Smith ER, Scott RM. Surgical management of moyamoya syndrome. Skull Base. 2005;15(1):15–26. http://www.ncbi.nlm.nih.gov/pubmed/16148981. Accessed 26 July 2016.
Kurehara K, et al. Cortical blood flow response to hypercapnia during anaesthesia in Moyamoya disease. Can J Anaesth. 1993;40(8):709–13. http://www.ncbi.nlm.nih.gov/pubmed/8403153. Accessed 26 July 2016.
Ely EW, et al. Delirium in mechanically ventilated patients: validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA. 2001;286(21):2703–10. http://www.ncbi.nlm.nih.gov/pubmed/11730446. Accessed 25 July 2016.
Tang J, Eckenhoff MF, Eckenhoff RG. Anesthesia and the old brain. Anesth Analg. 2010;110(2):421–6. http://www.ncbi.nlm.nih.gov/pubmed/19820235. Accessed 28 July 2016.
Ansaloni L, et al. Risk factors and incidence of postoperative delirium in elderly patients after elective and emergency surgery. Br J Surg. 2010;97(2):273–80. http://www.ncbi.nlm.nih.gov/pubmed/20069607. Accessed 25 July 2016.
Saczynski JS, et al. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–9. http://www.ncbi.nlm.nih.gov/pubmed/22762316. Accessed 25 July 2016.
Jørgensen ME, et al. Time elapsed after ischemic stroke and risk of adverse cardiovascular events and mortality following elective noncardiac surgery. JAMA. 2014;312(3):269–77. http://www.ncbi.nlm.nih.gov/pubmed/25027142. Accessed 26 July 2016.
Fox C, et al. Effect of medications with anti-cholinergic properties on cognitive function, delirium, physical function and mortality: a systematic review. Age Ageing. 2014;43(5):604–15. http://www.ncbi.nlm.nih.gov/pubmed/25038833. Accessed 18 July 2016.
Gray SL, et al. Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study. JAMA Intern Med. 2015;175(3):401–7. http://www.ncbi.nlm.nih.gov/pubmed/25621434. Accessed 26 July 2016.
van Munster B, et al. Longitudinal assessment of serum anticholinergic activity in delirium of the elderly. J Psychiatr Res. 2012;46:1339–45.
Vincent J-L, et al. Comfort and patient-centred care without excessive sedation: the eCASH concept. Intensive Care Med. 2016;42(6):962–71. http://www.ncbi.nlm.nih.gov/pubmed/27075762. Accessed 26 July 2016.
Dokkedal U, et al. Cognitive functioning after surgery in middle-aged and elderly Danish twins. J Neurosurg Anesthesiol. 2016;28(3):275. http://www.ncbi.nlm.nih.gov/pubmed/27187628. Accessed 26 July 2016.
Yeung J, et al. Regional versus general anaesthesia in elderly patients undergoing surgery for hip fracture: protocol for a systematic review. Systematic Reviews. 2016;5(1):66. http://www.ncbi.nlm.nih.gov/pubmed/27098125. Accessed 26 July 2016.
Selnes O, et al. Do management strategies for coronary artery disease influence 6-year cognitive outcomes? Ann Thorac Surg. 2009;88(2):445–54.
Vardy J, et al. Cognitive function and fatigue after diagnosis of colorectal cancer. Ann Oncol. 2014;25(12):2404–12. http://www.ncbi.nlm.nih.gov/pubmed/25214544. Accessed 26 July 2016.
Seitz DP, et al. Exposure to general anesthesia and risk of Alzheimer’s disease: a systematic review and meta-analysis. BMC Geriatr. 2011;11:83. http://www.ncbi.nlm.nih.gov/pubmed/22168260. Accessed 26 July 2016.
Bittner EA, Yue Y, Xie Z. Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer’s disease. Can J Anaesth. 2011;58(2):216–23. http://www.ncbi.nlm.nih.gov/pubmed/21174183. Accessed 28 July 2016.
Jiang J, Jiang H. Effect of the inhaled anesthetics isoflurane, sevoflurane and desflurane on the neuropathogenesis of Alzheimer’s disease (review). Mol Med Rep. 2015;12(1):3–12. http://www.ncbi.nlm.nih.gov/pubmed/25738734. Accessed 26 July 2016.
Zhang B, et al. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012;114(2):410–5. http://www.ncbi.nlm.nih.gov/pubmed/22075020. Accessed 26 July 2016.
Dorotta IR, Schubert A. Multiple sclerosis and anesthetic implications. Curr Opin Anaesthesiol. 2002;15(3):365–70. http://www.ncbi.nlm.nih.gov/pubmed/17019227. Accessed 28 July 2016.
Makris A, Piperopoulos A, Karmaniolou I. Multiple sclerosis: basic knowledge and new insights in perioperative management. J Anesth. 2014;28(2):267–78. http://www.ncbi.nlm.nih.gov/pubmed/23963466. Accessed 28 July 2016.
Mutluay FK, Gürses HN, Saip S. Effects of multiple sclerosis on respiratory functions. Clin Rehabil. 2005;19(4):426–32. http://www.ncbi.nlm.nih.gov/pubmed/15929512. Accessed 28 July 2016.
Vercauteren M, Heytens L. Anaesthetic considerations for patients with a pre-existing neurological deficit: are neuraxial techniques safe? Acta Anaesthesiol Scand. 2007;51(7):831–8. http://www.ncbi.nlm.nih.gov/pubmed/17488315. Accessed 28 July 2016.
Chhor V, et al. Anaesthesia and Parkinson’s disease. Ann Fr Anesth Reanim. 2011;30(7–8):559–68.
Goldstein D. Dysautonomia in Parkinson’s disease: neurocardiological abnormalities. Lancet Neurol. 2004;2(11):669–76.
Pal PK, et al. Pattern of subclinical pulmonary dysfunctions in Parkinson’s disease and the effect of levodopa. Mov Disord. 2007;22(3):420–4. http://www.ncbi.nlm.nih.gov/pubmed/17230476. Accessed 28 July 2016.
Pfeiffer R. Gastrointestinal dysfunction in Parkinson’s disease. Lancet Neurol. 2003;2(2):107–16.
Nicholson G, Pereira AC, Hall GM. Parkinson’s disease and anaesthesia. Br J Anaesth. 2002;89(6):904–16. http://www.ncbi.nlm.nih.gov/pubmed/12453936. Accessed 28 July 2016.
Bajwa SJS, Jindal R. Epilepsy and nonepilepsy surgery: recent advancements in anesthesia management. Anesth Essays Res. 2013;7(1):10–7. http://www.ncbi.nlm.nih.gov/pubmed/25885713. Accessed 28 July 2016.
Kofke WA. Anesthetic management of the patient with epilepsy or prior seizures. Curr Opin Anaesthesiol. 2010;23(3):391–9. http://www.ncbi.nlm.nih.gov/pubmed/20421790. Accessed 28 July 2016.
McGuire G, et al. Activation of electrocorticographic activity with remifentanil and alfentanil during neurosurgical excision of epileptogenic focus. Br J Anaesth. 2003;91(5):651–5. http://www.ncbi.nlm.nih.gov/pubmed/14570785. Accessed 28 July 2016.
Kurita N, et al. The effects of sevoflurane and hyperventilation on electrocorticogram spike activity in patients with refractory epilepsy. Anesth Analg. 2005;101(2):517–23. http://www.ncbi.nlm.nih.gov/pubmed/16037170. Accessed 28 July 2016.
Richard A, et al. Cisatracurium-induced neuromuscular blockade is affected by chronic phenytoin or carbamazepine treatment in neurosurgical patients. Anesth Analg. 2005;100(2):538–44. http://www.ncbi.nlm.nih.gov/pubmed/15673889. Accessed 28 July 2016.
Kopp SL, et al. Regional blockade in patients with a history of a seizure disorder. Anesth Analg. 2009;109(1):272–8. http://www.ncbi.nlm.nih.gov/pubmed/19535721. Accessed 28 July 2016.
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Binet, C., Lukaszewicz, A.C. (2018). Patients with Cerebral Diseases. In: Fellahi, JL., Leone, M. (eds) Anesthesia in High-Risk Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-60804-4_14
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DOI: https://doi.org/10.1007/978-3-319-60804-4_14
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