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The Role of Nitric Oxide from Neurological Disease to Cancer

  • Ahmed Maher
  • Mohamed F. Abdel Rahman
  • Mohamed Z. GadEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1007)

Abstract

Until the beginning of the 1980s, nitric oxide (NO) was just a toxic molecule of a lengthy list of environmental pollutants such as cigarette smoke and smog. In fact, NO had a very bad reputation of being destroyer of ozone, suspected carcinogen and precursor of acid rain. However, by the early 1990s it was well recognized by the medical research community. Over the last two decades, the picture has been totally changed. Diverse lines of evidence have converged to show that this sometime poison is a fundamental player in the everyday business of the human body. NO activity was probed in the brain, arteries, immune system, liver, pancreas, uterus, peripheral nerves, lungs, and almost every system in the human body. NO is a major player in the cardiovascular system as it is involved in regulating blood pressure. In the CNS, it is involved in memory formation and the regulation of cerebral blood flow to ensure adequate supply of blood to the brain. Because NO is involved in many pathways, it has a role in several diseases related to modern life as hypertension, coronary heart diseases, Alzheimer’s Disease, stroke and cancer. This chapter focuses on the discussion of the role of NO in neurological diseases and cancer and how can this Janus-faced molecule play a role in the pathology and personalized treatment of these diseases.

Keywords

Nitric oxide (NO) NO signal transduction CNS Neurodegeneration disorders Cancer NOS expression NO-targeted therapy 

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Copyright information

© American Association of Pharmaceutical Scientists 2017

Authors and Affiliations

  • Ahmed Maher
    • 1
  • Mohamed F. Abdel Rahman
    • 1
  • Mohamed Z. Gad
    • 2
    Email author
  1. 1.Biochemistry Department, Faculty of PharmacyOctober University for Modern Sciences and Arts (MSA)CairoEgypt
  2. 2.Clinical Biochemistry Unit, Faculty of Pharmacy & BiotechnologyGerman University in Cairo (GUC)CairoEgypt

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