Regenerative Medicine: Advances from Developmental to Degenerative Diseases

  • Nicholas F. Blair
  • Thomas J. R. Frith
  • Ivana BarbaricEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1007)


Chronic tissue and organ failure caused by an injury, disease, ageing or congenital defects represents some of the most complex therapeutic challenges and poses a significant financial healthcare burden. Regenerative medicine strategies aim to fulfil the unmet clinical need by restoring the normal tissue function either through stimulating the endogenous tissue repair or by using transplantation strategies to replace the missing or defective cells. Stem cells represent an essential pillar of regenerative medicine efforts as they provide a source of progenitors or differentiated cells for use in cell replacement therapies. Whilst significant leaps have been made in controlling the stem cell fates and differentiating them to cell types of interest, transitioning bespoke cellular products from an academic environment to off-the-shelf clinical treatments brings about a whole new set of challenges which encompass manufacturing, regulatory and funding issues. Notwithstanding the need to resolve such issues before cell replacement therapies can benefit global healthcare, mounting progress in the field has highlighted regenerative medicine as a realistic prospect for treating some of the previously incurable conditions.


Regenerative medicine Stem cells Spinal cord injury Parkinson’s Hirschprung’s 



We would like to thank Dr Paul J. Gokhale for critical reading of the manuscript. NFB and IB are supported by the UK Regenerative Medicine Platform (grant number MR/L012537/1). IB is also funded by the Medical Research Council (grant number MR/N009371/1) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668724.


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Copyright information

© American Association of Pharmaceutical Scientists 2017

Authors and Affiliations

  • Nicholas F. Blair
    • 1
  • Thomas J. R. Frith
    • 2
  • Ivana Barbaric
    • 2
    Email author
  1. 1.Wellcome Trust – MRC Cambridge Stem Cell InstituteUniversity of CambridgeCambridgeUK
  2. 2.Centre for Stem Cell Biology, Department of Biomedical ScienceThe University of SheffieldSheffieldUK

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