Abstract
There is a complex relationship among H. pylori, gastric acid production, and the development of reflux symptoms and disease. Studies that fail to address this complexity will not provide clear information on which to base clinical decisions and still not well understood in adults as well as in children.
The implications of H. pylori infection for the acquisition of GERD are a matter of current controversy. Some studies suggest a causative association between H. pylori infection and GERD, whereas others postulate a protective role for H. pylori infection. On balance and based on the pediatric published data, we consider that H. pylori eradication more likely to provide benefits than harm in children with GERD.
Frequency of GERD and clinical manifestations of H. pylori infection; relationship of H. pylori and erosive reflux disease; relationship of GERD and H. pylori CagA and VacA and other genes’ status; effect of H. pylori and type of gastritis on gastrin, ghrelin, motilin, and GERD; influence of H. pylori eradication on GERD symptoms; and, finally, influence of H. pylori on the development of EoE in children were all summarized in this chapter.
Keywords
Abbreviations
- CagA:
-
Cytotoxin-associated gene A
- DU:
-
Duodenal ulcers
- EoE:
-
Eosinophilic esophagitis
- ENT:
-
Ear nose throat
- eos/HPF:
-
Eosinophils per high-power field
- GERD:
-
Gastroesophageal reflux disease
- GER:
-
Gastroesophageal reflux
- H. pylori :
-
Helicobacter pylori
- IgE:
-
Immunoglobulin E
- LESP:
-
Lower esophageal sphincter pressure
- NUD:
-
Non-ulcer dyspepsia
- NERD:
-
Nonerosive reflux disease
- RUT:
-
Rapid urease test
- RAP:
-
Recurrent abdominal pain
- RE:
-
Reflux esophagitis
- PCR:
-
Polymerase chain reaction
- PPI:
-
Proton pump inhibitor
- upper GI endoscopy:
-
Upper gastrointestinal endoscopy
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Kalach, N. (2017). Gastroesophageal Reflux Disease and Helicobacter pylori in Children. In: Vandenplas, Y. (eds) Gastroesophageal Reflux in Children. Springer, Cham. https://doi.org/10.1007/978-3-319-60678-1_18
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