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Diagnosis of Alzheimer Disease Through an Artificial Neural Network Based System

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Advances in Human Factors in Simulation and Modeling (AHFE 2017)

Abstract

Alzheimer’s Disease (AD) is referred to as one of the most common causes of dementia, which in itself justifies the interest and investment that is made in order to find new biomarkers to identify the disease in its early stages. Indeed, focusing on the hippocampus as a marker for AD, it would be object of analyse different methods of volume measurement and hippocampus segmentation. On the other hand, the computational framework is built on top of a Logic Programming approach to Knowledge Representation and Reasoning, complemented with a computational framework base on Artificial Neural Networks that grip on incomplete, unknown, and even self-contradictory information or knowledge.

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References

  1. Sørensen, L., Igel, C., Hansen, N.L., Osler, M., Lauritzen, M., Rostrup, E., Nielsen, M.: Early detection of Alzheimer’s disease using MRI hippocampal texture. Hum. Brain Mapp. 37, 1148–1161 (2016)

    Article  Google Scholar 

  2. Alzheimer’s Association: 2015 Alzheimer’s disease facts and figures. Alzheimer’s Dementia 11, 332–384 (2015)

    Google Scholar 

  3. Vijayakumar, A., Vijayakumar, A.: Comparison of hippocampal volume in dementia subtypes. ISRN Radiology 2013, Article ID 174524 (2013)

    Google Scholar 

  4. Johnson, K.A., Fox, N.C., Sperling, R.A., Klunk, W.E.: Brain imaging in Alzheimer disease. Cold Spring Harb. Perspect. Med. 2, a006213 (2012)

    Article  Google Scholar 

  5. Bakkour, A., Morris, J.C., Wolk, D.A., Dickerson, B.C.: The effects of aging and Alzheimer’s disease on cerebral cortical anatomy: specificity and differential relationships with cognition. Neuroimage 76, 332–344 (2013)

    Article  Google Scholar 

  6. Promteangtrong, C., Kolber, M., Ramchandra, P., Moghbel, M., Houshmand, S., Schöll, M., Bai, H., Werner, T.J., Alavi, A., Buchpiguel, C.: Multimodality imaging approach in Alzheimer disease. Part I: structural MRI, functional MRI, diffusion tensor imaging and magnetization transfer imaging. Dement. Neuropsychol. 9, 318–329 (2015)

    Article  Google Scholar 

  7. Jaba, L.S., Shanthi, V., Singh, D.J.: Estimation of hippocampus volume from MRI using ImageJ for Alzheimer’s diagnosis. Atlas J. Med. Biol. Sci. 1, 15–20 (2011)

    Article  Google Scholar 

  8. den Heijer, T., van der Lijn, F., Koudstaal, P.J., Hofman, A., van der Lugt, A., Krestin, G.P., Niessen, W.J., Breteler, M.M.: A 10-year follow-up of hippocampal volume on magnetic resonance imaging in early dementia and cognitive decline. Brain 133, 1163–1172 (2010)

    Article  Google Scholar 

  9. Neves, J., Machado, J., Analide, C., Abelha, A., Brito, L.: The halt condition in genetic programming. In: Neves, J., Santos, M.F., Machado, J. (eds.) Progress in Artificial Intelligence. LNAI, vol. 4874, pp. 160–169. Springer, Berlin (2007)

    Chapter  Google Scholar 

  10. Neves, J.: A logic interpreter to handle time and negation in logic databases. In: Muller, R., Pottmyer, J. (eds.) Proceedings of the 1984 Annual Conference of the ACM on the 5th Generation Challenge, pp. 50–54. Association for Computing Machinery, New York (1984)

    Google Scholar 

  11. Vicente, H., Dias, S., Fernandes, A., Abelha, A., Machado, J., Neves, J.: Prediction of the quality of public water supply using artificial neural networks. J. Water Supply: Res. Technol. – AQUA 61, 446–459 (2012)

    Article  Google Scholar 

  12. Haykin, S.: Neural Networks and Learning Machines. Prentice Hall, New York (2008)

    Google Scholar 

  13. Kakas, A., Kowalski, R., Toni, F.: The role of abduction in logic programming. In: Gabbay, D., Hogger, C., Robinson, I. (eds.) Handbook of Logic in Artificial Intelligence and Logic Programming, vol. 5, pp. 235–324. Oxford University Press, Oxford (1998)

    Google Scholar 

  14. Pereira, L., Anh, H.: Evolution prospection. In: Nakamatsu, K. (ed.) New Advances in Intelligent Decision Technologies – Results of the First KES International Symposium IDT 2009. Studies in Computational Intelligence, vol. 199, pp. 51–64. Springer, Berlin (2009)

    Google Scholar 

  15. Machado, J., Abelha, A., Novais, P., Neves, J., Neves, J.: Quality of service in healthcare units. In: Bertelle, C., Ayesh, A. (eds.) Proceedings of the ESM 2008, pp. 291–298. Eurosis – ETI Publication, Ghent (2008)

    Google Scholar 

  16. Lucas, P.: Quality checking of medical guidelines through logical abduction. In: Coenen, F., Preece, A., Mackintosh, A. (eds.) Research and Developments in Intelligent Systems XX, pp. 309–321. Springer, London (2004)

    Chapter  Google Scholar 

  17. Fernandes, F., Vicente, H., Abelha, A., Machado, J., Novais, P., Neves J.: Artificial neural networks in diabetes control. In: Proceedings of the 2015 Science and Information Conference (SAI 2015), pp. 362–370. IEEE Edition (2015)

    Google Scholar 

  18. Open Access Series of Imaging Studies. http://www.oasis-brains.org/app/template/Index.vm

  19. Reitz, C., Mayeux, R.: Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem. Pharmacol. 88, 640–651 (2014)

    Article  Google Scholar 

  20. Rasband, W.S.: ImageJ. U.S. National Institutes of Health, Bethesda, Maryland, USA (1997–2015). http://imagej.nih.gov/ij/

  21. Tae, W.S., Kim, S.S., Lee, K.U., Nam, E.C., Kim, K.W.: Validation of hippocampal volumes measured using a manual method and two automated methods (FreeSurfer and IBASPM) in chronic major depressive disorder. Neuroradiology 50, 569–581 (2008)

    Article  Google Scholar 

  22. Carneiro, D., Novais, P., Andrade, F., Zeleznikow, J., Neves, J.: Using case-based reasoning and principled negotiation to provide decision support for dispute resolution. Knowl. Inf. Syst. 36, 789–826 (2013)

    Article  Google Scholar 

  23. Mendes, R., Kennedy, J., Neves, J.: The fully informed particle swarm: simpler, maybe better. IEEE Trans. Evol. Comput. 8, 204–210 (2004)

    Article  Google Scholar 

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Acknowledgments

This work has been supported by COMPETE: POCI-01-0145-FEDER-007043 and FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2013.

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Correspondence to José Neves .

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Ramalhosa, I. et al. (2018). Diagnosis of Alzheimer Disease Through an Artificial Neural Network Based System. In: Cassenti, D. (eds) Advances in Human Factors in Simulation and Modeling. AHFE 2017. Advances in Intelligent Systems and Computing, vol 591. Springer, Cham. https://doi.org/10.1007/978-3-319-60591-3_15

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  • DOI: https://doi.org/10.1007/978-3-319-60591-3_15

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