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Microfluidics in Cell and Tissue Studies

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Book cover Tumor Organoids

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The central challenge inherent to conventional cell culture systems in general and tumor systems in particular is that any but the most rudimentary studies requires an enormous amount of infrastructure and handling capabilities to investigate numerous, interdependent variables in discrete samples. In addition, analysis of outcomes is both separate and potentially challenging. Significant strides have been made to address both of these challenges through the use of microfluidic technologies and cell culture techniques toward the goal of an integrated delivery and assessment platform that recapitulates in vivo conditions. Here, we review microfluidic approaches that enable the study of cells and cell culture, with specific applications to cancer cells and tumor organoids.

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Authors and Affiliations

  1. Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Shiny Amala Priya Rajan, Parker Hambright, Rosemary Clare Burke & Adam R. Hall

  2. Department of Biology, Wake Forest University, Winston-Salem, NC, USA

    Parker Hambright

  3. Department of Biomedical Engineering, University of Texas Austin, Austin, TX, USA

    Rosemary Clare Burke

  4. Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Adam R. Hall

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  1. Shiny Amala Priya Rajan
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  2. Parker Hambright
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  3. Rosemary Clare Burke
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  4. Adam R. Hall
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Correspondence to Adam R. Hall .

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Editors and Affiliations

  1. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Shay Soker

  2. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Aleksander Skardal

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Rajan, S.A.P., Hambright, P., Burke, R.C., Hall, A.R. (2018). Microfluidics in Cell and Tissue Studies. In: Soker, S., Skardal, A. (eds) Tumor Organoids. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60511-1_8

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