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Mammary Gland Organoids

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Tumor Organoids

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The study of the mechanisms that regulate development and tumorigenesis is a complex undertaking that requires a variety of model systems to test hypothesis that embrace all levels of organization: from single cells to organs. In the mammary gland field, the use of three-dimensional culture systems has provided a platform to study, in a physiologically relevant setting, cell biology in context. In the late 50’s methods to isolate primary mammary organoids were established and since then they have been increasingly used to understand cell behavior. In this chapter we embrace, in a historical perspective, the key findings carried out using primary mammary organoids considering that the broadening of our knowledge will, in the future, rely increasingly on this kind of tridimensional culture setting.

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Acknowledgements

This book chapter was supported by a grant from the Instituto Nacional del Cáncer, Ministerio de Salud, República Argentina to M.S. M.S. is a career Conicet scientist. S.R. and I.D.B. are supported by Conicet fellowships.

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Authors and Affiliations

  1. Instituto de Nanosistemas, Universidad Nacional de San Martín, San Martín, Buenos Aires, Argentina

    Rocío Sampayo PhD

  2. Instituto de Oncología “Angel H. Roffo”, Avda San Martín, 5481, Ciudad de Buenos Aires, Argentina

    Sol Recouvreux MSc

  3. Instituto de Nanosistemas, Universidad Nacional de San Martín, San Martín, 1650, Buenos Aires, Argentina

    María Inés Diaz Bessone PhD & Marina Simian PhD

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  1. Rocío Sampayo PhD
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  2. Sol Recouvreux MSc
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  3. María Inés Diaz Bessone PhD
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  4. Marina Simian PhD
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Correspondence to Marina Simian PhD .

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Editors and Affiliations

  1. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Shay Soker

  2. Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA

    Aleksander Skardal

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Sampayo, R., Recouvreux, S., Bessone, M.I.D., Simian, M. (2018). Mammary Gland Organoids. In: Soker, S., Skardal, A. (eds) Tumor Organoids. Cancer Drug Discovery and Development. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60511-1_3

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  • DOI: https://doi.org/10.1007/978-3-319-60511-1_3

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