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Hepatobiliary and Pancreatic Malignancies: Epidemiology, Clinical Presentation, Diagnosis, and Staging

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Book cover PET/CT in Hepatobiliary and Pancreatic Malignancies

Part of the book series: Clinicians’ Guides to Radionuclide Hybrid Imaging ((PET/CT))

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Abstract

Hepatobiliary and pancreatic malignancies constitute a diverse range of disease processes, each with its own pathogenesis, presentation, and staging. This chapter will summarize the epidemiology, clinical presentation, diagnosis, and staging of hepatocellular carcinoma, carcinoma of the gall bladder and bile ducts, and pancreatic cancer.

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References

  1. Jemal A, Bray F, Centre MM, et al. Global cancer statistics. CA Cancer J Clin. 2011;61:69.

    Article  PubMed  Google Scholar 

  2. Perz JF, Armstrong GL, Farrington LA, et al. The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. J Heptol. 2006;45:529.

    Article  Google Scholar 

  3. Beasley RP, Hwang LY, Lin CC, Chien CS. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan. Lancet. 1981;2:1129.

    Article  CAS  PubMed  Google Scholar 

  4. Colombo M, deFranchis R, Del Ninni E, et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med. 1991;325:675.

    Article  CAS  Google Scholar 

  5. Kew MC, Dos Santos HA, Sherlock S. Diagnosis of primary cancer of the liver. Br Med J. 1971;4:408.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Schwartz JM, Larson AM, Gold PJ, et al. Hepatocellular carcinoma: A one year experience at a tertiary referral center in the United States (abstract). Heptatology. 1999;278A:30.

    Google Scholar 

  7. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients: the Cancer of the Liver Italian Program (CLIP) investigators. Hepatology 1998;28:751.

    Google Scholar 

  8. Bruix J, Sherman M. American Association for the Study of Liver Diseases. Management of hepatocellular carcinoma an update. Hepatology. 2011;53:1020.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Sterling RK, Wright EC, Morgan TR, et al. Frequency of elevated hepatocellular carcinoma (HCC) biomarkers in patients with advanced hepatitis C. Am J Gastroenterol. 2012;107:64.

    Article  CAS  PubMed  Google Scholar 

  10. Serum WJT. alpha-fetoprotein and its lectin reactivity in liver diseases: a review. Ann Clin Lab Sci. 1990;20:98.

    Google Scholar 

  11. Ioannou GN, Perkins JD, Carithers RL Jr. Liver transplantation for hepatocellular carcinoma: impact of the MELD allocation system and predictors of survival. Gastroenterology 2008;134:1342.

    Google Scholar 

  12. American Joint Committee on Cancer Staging Manual. 7th, Edge SB, Byrd DR, Compton CC, et al (Eds). New York: Springer; 2010.

    Google Scholar 

  13. Randi G, Franceschi S, La Vecchia C. Gall bladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006;118:1591.

    Article  CAS  PubMed  Google Scholar 

  14. Carriaga MT, Henson DE. Liver, gallbladder, extrahepatic bile duct, and pancreas. Cancer. 1995;75:171.

    Article  CAS  PubMed  Google Scholar 

  15. Bismuth H, Nakache R, Diamond T. Management strategies in resection for hilar cholangiocarcinoma. Ann Surg. 1992;215:31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Lee SS, Kim MH, Lee SK, et al. Clinicopathologic review of 58 patients with biliary papillomatosis. Cancer. 2004;100:783.

    Article  PubMed  Google Scholar 

  17. Saha SK, Zhu AX, Fuchs CS, Brooks GA. Forty-year trends in cholangiocarcinoma incidence in the U.S.: intrahepatic disease on the rise. Oncologist. 2016;21:594.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Kubota K, Bandai Y, Noie T, et al. How should polyploidy lesions of the gall bladder be treated in the era of laparoscopic cholecystectomy? Surgery. 1995;117:481.

    Article  CAS  PubMed  Google Scholar 

  19. Petrowsky H, Wildbrett P, Husarik DB, et al. Impact of integrated positron emission tomography and computed tomography on staging and management of gall bladder cancer and cholangiocarcinoma. J Hepatol. 2006;45:43.

    Article  PubMed  Google Scholar 

  20. Boyle P, Hseih CC, Maisonneuve P, et al. Epidemiology oc pancreas cancer (1988). Int J Pancreatol. 1989;5:327.

    Article  CAS  PubMed  Google Scholar 

  21. Modolell I, Guarner L, Malagelada JR. Vagaries of clinical presentation of pancreatic and biliary tract cancer. Ann Oncol. 1999;10(Suppl 4):82.

    Article  PubMed  Google Scholar 

  22. Aggarwal G, Kamada P, Chari ST. Prevalence of diabetes mellitus in pancreatic cancer compared to common cancers. Pancreas. 2013;42:198.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Nino-Murcia M, Jeffrey RB Jr, Beaulieu CF, et al. Multidetector CT of the pancreas and bile duct system: value of curved planar reformations. AJR Am J Roentgenol 2001;176:689.

    Google Scholar 

  24. Humphris JL, Chang DK, Johns AL, et al. The prognostic and predictive value of serum Ca 19.9 in pancreatic cancer. Ann Oncol. 2012;23:1713.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Karachristos A, Scarmeas N, Hoffman JP. CA 19-9 level predict results of staging laparoscopy in pancreatic cancer. J Gastroinest Surg. 2005;9:1286.

    Article  Google Scholar 

  26. Fujioka S, Misawa T, Okamoto T, et al. preoperative serum carcinoembryonic antigen and carbohydrate antigen 19-9 level for the evaluation of curability and resectability in patients with pancreatic adenocarcinoma. J Hepatobiliary Pancreat Surg. 2007;14:539.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Gastrointestinal and HPB Surgery, Tata Memorial Centre, Mumbai, Maharashtra, India

    Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B.

Authors
  1. Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B.
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Correspondence to Ashwin deSouza M.S., M.Ch., M.R.C.S.Ed., D.N.B. .

Editor information

Editors and Affiliations

  1. Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Nilendu Purandare

  2. Department of Nuclear Medicine and Molecular Imaging, Tata Memorial Hospital, Mumbai, Maharashtra, India

    Sneha Shah

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deSouza, A. (2018). Hepatobiliary and Pancreatic Malignancies: Epidemiology, Clinical Presentation, Diagnosis, and Staging. In: Purandare, N., Shah, S. (eds) PET/CT in Hepatobiliary and Pancreatic Malignancies. Clinicians’ Guides to Radionuclide Hybrid Imaging(). Springer, Cham. https://doi.org/10.1007/978-3-319-60507-4_1

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  • DOI: https://doi.org/10.1007/978-3-319-60507-4_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60506-7

  • Online ISBN: 978-3-319-60507-4

  • eBook Packages: MedicineMedicine (R0)

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