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The Global Burden of Diabetes and Its Vascular Complications

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Mechanisms of Vascular Defects in Diabetes Mellitus

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 17))

Abstract

Diabetes, one of the most common metabolic disorders, is no longer a disease of affluent nations. The prevalence rates of diabetes are rising steeply in low and middle-income nations that have rapidly improved their economy and adopted a ‘westernized’ life style. The worldwide explosion of diabetes also increases the propensity for developing both micro and macro vascular complications and this result in a huge burden due to mobility and mortality in addition to increasing the costs of therapy. As both micro and macrovascular complications share common pathophysiological mechanisms, several studies have shown a strong association between the various vascular complications. Thus, screening for all diabetic complications simultaneously is recommended. If the burden due to diabetes and its complications is to be reduced, there is need for a multi-prolonged strategy involving early diagnosis of diabetes, screening for its complications and offering optimal therapy at all levels of care. Luckily, effective interventions are available, making such efforts justifiable.

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Authors and Affiliations

  1. Madras Diabetes Research Foundation & Dr. Mohan’s Diabetes Specialties Centre, WHO Collaborating Centre for Noncommunicable Diseases Prevention and Control & ICMR Centre for Advanced Research on Diabetes, Chennai, Tamil Nadu, India

    Viswanathan Mohan M.D., Ph.D., D.Sc. & Rajendra Pradeepa

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  1. Viswanathan Mohan M.D., Ph.D., D.Sc.
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  2. Rajendra Pradeepa
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Correspondence to Viswanathan Mohan M.D., Ph.D., D.Sc. .

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  1. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    C.C. Kartha

  2. Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Surya Ramachandran

  3. Translational Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Radhakrishna M. Pillai

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Mohan, V., Pradeepa, R. (2017). The Global Burden of Diabetes and Its Vascular Complications. In: Kartha, C., Ramachandran, S., Pillai, R. (eds) Mechanisms of Vascular Defects in Diabetes Mellitus. Advances in Biochemistry in Health and Disease, vol 17. Springer, Cham. https://doi.org/10.1007/978-3-319-60324-7_1

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