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Effects of Fetal Programming on Metabolic Syndrome

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Diet, Nutrition, and Fetal Programming

Part of the book series: Nutrition and Health ((NH))

Abstract

The concept of developmental origins of health and disease conveys the notion that the exposure to an unfavorable environment during pregnancy and lactation programs changes in fetal or neonatal metabolism, which in turn increases the risks of developing diseases in adult life. The evidence for fetal programming for metabolic diseases derives from a large number of epidemiological and animal observations. Several nutritional interventions and exposures during diverse phases of pregnancy and lactation in rodents and humans, respectively, are associated with fetal and neonatal programming for metabolic syndrome. In this chapter, we revisit epidemiological studies and experimental models providing evidence for the fetal programming associated with the development of metabolic diseases.

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Abbreviations

HOMA-IR:

Homeostatic model assessment-insulin resistance

HPA:

Hypothalamic-pituitary-adrenocortical

ROS:

Reactive oxygen species

SD:

Sprague-Dawley

WIS:

Wistar

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Author information

Authors and Affiliations

  1. Department of Internal Medicine – Endocrinology and Metabolism, FOE Diabetes Research Center, University of Iowa, Iowa City, IA, USA

    Renata Pereira Alambert & Marcelo Lima de Gusmão Correia

Authors
  1. Renata Pereira Alambert
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  2. Marcelo Lima de Gusmão Correia
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Corresponding author

Correspondence to Renata Pereira Alambert .

Editor information

Editors and Affiliations

  1. Department of Nutrition, King's College, London, United Kingdom

    Rajkumar Rajendram

  2. Department of Nutrition, King's College, London, United Kingdom

    Victor R. Preedy

  3. Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

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Alambert, R.P., de Gusmão Correia, M.L. (2017). Effects of Fetal Programming on Metabolic Syndrome. In: Rajendram, R., Preedy, V., Patel, V. (eds) Diet, Nutrition, and Fetal Programming. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60289-9_32

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  • DOI: https://doi.org/10.1007/978-3-319-60289-9_32

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-60287-5

  • Online ISBN: 978-3-319-60289-9

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