Manganese and Developmental Neurotoxicity

  • Roberto LucchiniEmail author
  • Donatella Placidi
  • Giuseppa Cagna
  • Chiara Fedrighi
  • Manuela Oppini
  • Marco Peli
  • Silvia Zoni
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 18)


Manganese (Mn) is an essential metal that plays a fundamental role for brain development and functioning. Environmental exposure to Mn may lead to accumulation in the basal ganglia and development of Parkinson-like disorders. The most recent research is focusing on early-life overexposure to Mn and the potential vulnerability of younger individuals to Mn toxicity also in regard to cognitive and executive functions through the involvement of the frontal cortex.

Neurodevelopmental disturbances are increasing in the society, and understanding the potential role of environmental determinants is a key for prevention. Therefore, assessing the environmental sources of Mn exposure and the mechanisms of developmental neurotoxicity and defining appropriate biomarkers of exposure and early functional alterations represent key issues to improve and address preventive strategies. These themes will be reviewed in this chapter.


Basal ganglia Vehicle emissions Methylcyclopentadienyl Mn tricarbonyl (MMT) Fungicides Deposited dust Revised Conners’ Teacher Rating Scale Wechsler Intelligence Scale for Children (WISC) Olfactory loss 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Roberto Lucchini
    • 1
    • 2
    Email author
  • Donatella Placidi
    • 2
  • Giuseppa Cagna
    • 2
  • Chiara Fedrighi
    • 2
  • Manuela Oppini
    • 2
  • Marco Peli
    • 2
  • Silvia Zoni
    • 2
  1. 1.Department of Environmental Medicine and Public HealthIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Department of Medical and Surgical Specialties, Radiological Sciences and Public HealthUniversity of BresciaBresciaItaly

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