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Developmental Neurotoxicity of Lead

  • Samuel Caito
  • Michael AschnerEmail author
Chapter
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 18)

Abstract

Lead exposure is a major concern for the developing nervous system. Environmental exposures to lead, predominantly from contaminated water or lead paint chips, account for the majority of exposures to children. In utero and early life exposures to lead have been associated with lower IQ, antisocial and delinquent behaviors, and attention-deficit hyperactivity disorder. In this review, we will discuss sources of developmental lead exposure and mechanisms of lead neurotoxicity. We will highlight both human epidemiological studies showing associations between lead exposure and behavioral abnormalities as well as experimental data from animal studies. Finally, we will discuss the effects of lead on neurological endpoint past childhood, namely, development of Alzheimer’s disease in old age.

Keywords

Air quality criteria Behavioral impairments Permissible exposure limit (PEL) Encephalopathy Metalloproteins Alzheimer’s disease 

References

  1. Alkondon M, Costa AC, Radhakrishnan V, Aronstam RS, Albuquerque EX. FEBS Lett. 1990;261(1):124–30.CrossRefPubMedGoogle Scholar
  2. Altmann L, Weinsberg F, Sveinsson K, Lilienthal H, Wiegand H, Winneke G. Toxicol Lett. 1993;66(1):105–12.CrossRefPubMedGoogle Scholar
  3. Atchison WD, Narahashi T. Neurotoxicology. 1984;5(3):267–82.PubMedGoogle Scholar
  4. Baranowska-Bosiacka I, Gutowska I, Marchetti C, Rutkowska M, Marchlewicz M, Kolasa A, Prokopowicz A, Wiernicki I, Piotrowska K, Baskiewicz M, Safranow K, Wiszniewska B, Chlubek D. Toxicology. 2011;280(1-2):24–32.CrossRefPubMedGoogle Scholar
  5. Basha MR, Murali M, Siddiqi HK, Ghosal K, Siddiqi OK, Lashuel HA, Ge YW, Lahiri DK, Zawia NH. FASEB J Off Publ Feder Am Soc Exp Biol. 2005a;19(14):2083–4.Google Scholar
  6. Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, Lahiri DK, Zawia NH. J Neurosci Off J Soc Neurosci. 2005b;25(4):823–9.CrossRefGoogle Scholar
  7. Bellinger DC, Bellinger AM. J Clin Invest. 2006;116(4):853–7.CrossRefPubMedPubMedCentralGoogle Scholar
  8. Bihaqi SW, Bahmani A, Subaiea GM, Zawia NH. Alzheimers Dement. 2014a;10(2):187–95.CrossRefPubMedGoogle Scholar
  9. Bihaqi SW, Bahmani A, Adem A, Zawia NH. Neurotoxicology. 2014b;44:114–20.CrossRefPubMedGoogle Scholar
  10. Boucher O, Jacobson SW, Plusquellec P, Dewailly E, Ayotte P, Forget-Dubois N, Jacobson JL, Muckle G. Environ Health Perspect. 2012;120(10):1456–61.CrossRefPubMedPubMedCentralGoogle Scholar
  11. Chamberlain A, Heard C, Little M. Philos Trans R Soc Lond A. 1978;290:557–89.Google Scholar
  12. Chen A, Dietrich KN, Ware JH, Radcliffe J, Rogan WJ. Environ Health Perspect. 2005;113(5):597–601.CrossRefPubMedPubMedCentralGoogle Scholar
  13. Cory-Slechta DA, Virgolini MB, Thiruchelvam M, Weston DD, Bauter MR. Environ Health Perspect. 2004;112(6):717–30.CrossRefPubMedPubMedCentralGoogle Scholar
  14. Dietrich KN, Ris MD, Succop PA, Berger OG, Bornschein RL. Neurotoxicol Teratol. 2001;23(6):511–8.CrossRefPubMedGoogle Scholar
  15. Dosunmu R, Alashwal H, Zawia NH. Mech Ageing Dev. 2012;133(6):435–43.CrossRefPubMedPubMedCentralGoogle Scholar
  16. Edwards M, Triantafyllidou S, Best D. Environ Sci Technol. 2009;43(5):1618–23.CrossRefPubMedGoogle Scholar
  17. Ettinger AS, Tellez-Rojo MM, Amarasiriwardena C, Peterson KE, Schwartz J, Aro A, Hu H, Hernandez-Avila M. Am J Epidemiol. 2006;163(1):48–56.CrossRefPubMedGoogle Scholar
  18. Gasana J, Chamorro A. J Expo Anal Environ Epidemiol. 2002;12(4):265–72.CrossRefPubMedGoogle Scholar
  19. Giacoppo S, Galuppo M, Calabro RS, D'Aleo G, Marra A, Sessa E, Bua DG, Potorti AG, Dugo G, Bramanti P, Mazzon E. Biol Trace Elem Res. 2014;161(2):151–60.CrossRefPubMedGoogle Scholar
  20. Gilbert ME, Mack CM. Brain Res. 1998;789(1):139–49.CrossRefPubMedGoogle Scholar
  21. Gilbert ME, Mack CM, Lasley SM. Brain Res. 1996;736(1-2):118–24.CrossRefPubMedGoogle Scholar
  22. Gilbert ME, Mack CM, Lasley SM. Neurotoxicology. 1999;20:57–70.PubMedGoogle Scholar
  23. Gulson BL, Mizon KJ, Korsch MJ, Palmer JM, Donnelly JB. Sci Total Environ. 2003;303(1–2):79–104.CrossRefPubMedGoogle Scholar
  24. Hanas JS, Rodgers JS, Bantle JA, Cheng YG. Mol Pharmacol. 1999;56(5):982–8.PubMedGoogle Scholar
  25. Haraguchi T, Ishizu H, Takehisa Y, Kawai K, Yokota O, Terada S, Tsuchiya K, Ikeda K, Morita K, Horike T, Kira S, Kuroda S. Neuroreport. 2001a;12(18):3887–90.CrossRefPubMedGoogle Scholar
  26. Haraguchi T, Ishizu H, Kawai K, Tanabe Y, Uehira K, Takehisa Y, Terada S, Tsuchiya K, Ikeda K, Kuroda S. Neuroreport. 2001b;12(6):1257–60.CrossRefPubMedGoogle Scholar
  27. Harville EW, Hertz-Picciotto I, Schramm M, Watt-Morse M, Chantala K, Osterloh J, Parsons PJ, Rogan W. Occup Environ Med. 2005;62(4):263–9.CrossRefPubMedPubMedCentralGoogle Scholar
  28. Hernberg S. Am J Ind Med. 2000;38(3):244–54.CrossRefPubMedGoogle Scholar
  29. Hu H, Tellez-Rojo MM, Bellinger D, Smith D, Ettinger AS, Lamadrid-Figueroa H, Schwartz J, Schnaas L, Mercado-Garcia A, Hernandez-Avila M. Environ Health Perspect. 2006;114(11):1730–5.PubMedPubMedCentralGoogle Scholar
  30. Kim S, Arora M, Fernandez C, Landero J, Caruso J, Chen A. Environ Res. 2013;126:105–10.CrossRefPubMedGoogle Scholar
  31. Kumar BK, Reddy AG, Krishna AV, Quadri SS, Kumar PS. Vet World. 2016;9(2):133–41.CrossRefPubMedPubMedCentralGoogle Scholar
  32. Lanphear BP, Hornung R, Khoury J, Yolton K, Baghurst P, Bellinger DC, Canfield RL, Dietrich KN, Bornschein R, Greene T, Rothenberg SJ, Needleman HL, Schnaas L, Wasserman G, Graziano J, Roberts R. Environ Health Perspect. 2005;113(7):894–9.CrossRefPubMedPubMedCentralGoogle Scholar
  33. Lasley SM, Gilbert ME. Toxicol Appl Pharmacol. 1999;159(3):224–33.CrossRefPubMedGoogle Scholar
  34. Lasley SM, Green MC, Gilbert ME. Neurotoxicology. 1999;20:619–30.PubMedGoogle Scholar
  35. Luo M, Xu Y, Cai R, Tang Y, Ge MM, Liu ZH, Xu L, Hu F, Ruan DY, Wang HL. Toxicol Lett. 2014;225(1):78–85.CrossRefPubMedGoogle Scholar
  36. Mahaffey KR, Annest JL, Murphy RS. N Engl J Med. 1983;307:573–9.CrossRefGoogle Scholar
  37. Major RH. Ann Med Hist. 1931;3:218–27.Google Scholar
  38. Markovac J, Goldstein GW. Nature. 1988;334(6177):71–3.CrossRefPubMedGoogle Scholar
  39. Masoud AM, Bihaqi SW, Machan JT, Zawia NH, Renehan WE. J Alzheimers Dis. 2016;Google Scholar
  40. Matthies H, Frey U, Reymann K, Krug M, Jork R, Schroeder H. Adv Exp Med Biol. 1990;268:359–68.CrossRefPubMedGoogle Scholar
  41. Mielke HW, Reagan PL. Environ Health Perspect. 1998;106(Suppl 1):217–29.CrossRefPubMedPubMedCentralGoogle Scholar
  42. Minnema DJ, Michaelson IA, Cooper GP. Toxicol Appl Pharmacol. 1988;92(3):351–7.CrossRefPubMedGoogle Scholar
  43. Neal AP, Guilarte TR. Mol Neurobiol. 2010;42(3):151–60.CrossRefPubMedPubMedCentralGoogle Scholar
  44. Neal AP, Stansfield KH, Worley PF, Thompson RE, Guilarte TR. Toxicol Sci. 2010;116(1):249–63.CrossRefPubMedPubMedCentralGoogle Scholar
  45. Needleman H. Annu Rev Med. 2004;55:209–22.CrossRefPubMedGoogle Scholar
  46. Needleman HL, McFarland C, Ness RB, Fienberg SE, Tobin MJ. Neurotoxicol Teratol. 2002;24(6):711–7.CrossRefPubMedGoogle Scholar
  47. Nevin R. Environ Res. 2000;83(1):1–22.CrossRefPubMedGoogle Scholar
  48. Nicolescu R, Petcu C, Cordeanu A, Fabritius K, Schlumpf M, Krebs R, Kramer U, Winneke G. Environ Res. 2010;110(5):476–83.CrossRefPubMedGoogle Scholar
  49. Popma A, Jansen LM, Vermeiren R, Steiner H, Raine A, Van Goozen SH, van Engeland H, Doreleijers TA. Psychoneuroendocrinology. 2006;31(8):948–57.CrossRefPubMedGoogle Scholar
  50. Reymann KG, Frey JU. Neuropharmacology. 2007;52(1):24–40.CrossRefPubMedGoogle Scholar
  51. Rodgers JS, Hocker JR, Hanas RJ, Nwosu EC, Hanas JS. Biochem Pharmacol. 2001;61(12):1543–50.CrossRefPubMedGoogle Scholar
  52. Ruocco LA, Treno C, Gironi Carnevale UA, Arra C, Boatto G, Pagano C, Tino A, Nieddu M, Michel M, Prikulis I, Carboni E, de Souza Silva MA, Huston JP, Sadile AG, Korth C. Amino Acids. 2015;47(3):637–50.CrossRefPubMedGoogle Scholar
  53. Sanchez-Martin FJ, Fan Y, Lindquist DM, Xia Y, Puga A. PLoS One. 2013;8(11):e80558.CrossRefPubMedPubMedCentralGoogle Scholar
  54. Schneider JS, Kidd SK, Anderson DW. Toxicol Lett. 2013;217(1):75–81.CrossRefPubMedGoogle Scholar
  55. Stretesky PB, Lynch MJ. Arch Pediatr Adolesc Med. 2001;155(5):579–82.CrossRefPubMedGoogle Scholar
  56. Sui L, Ruan DY, Ge SY, Meng XM. Neurotoxicol Teratol. 2000a;22(5):741–9.CrossRefPubMedGoogle Scholar
  57. Sui L, Ge SY, Ruan DY, Chen JT, Xu YZ, Wang M. Neurotoxicol Teratol. 2000b;22(3):381–7.CrossRefPubMedGoogle Scholar
  58. US Environmental Protection Agency. Air quality criteria for lead. Research Triangle Park: Health Effects Research Laboratory, Criteria and Special Studies Office; 1977.Google Scholar
  59. US Environmental Protection Agency. Air quality criteria for lead, Office of Health and Environmental Assessment. Research Triangle Park: Environmental Criteria and Assessment Office; 1986.Google Scholar
  60. US Environmental Protection Agency. Air quality criteria for lead, vol. I and II of II. Research Triangle Park: National Center for Environmental Assessment – RTP Office; 2006.Google Scholar
  61. Virgolini MB, Bauter MR, Weston DD, Cory-Slechta DA. Neurotoxicology. 2006;27(1):11–21.CrossRefPubMedGoogle Scholar
  62. White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian YC, Basha MR. Toxicol Appl Pharmacol. 2007;225(1):1–27.CrossRefPubMedGoogle Scholar
  63. Winneke G, Lilienthal H, Kramer U. Arch Toxicol Suppl. 1996;18:57–70.CrossRefPubMedGoogle Scholar
  64. Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, Harry J, Rice DC, Maloney B, Chen D, Lahiri DK, Zawia NH. J Neurosci Off J Soc Neurosci. 2008;28(1):3–9.CrossRefGoogle Scholar
  65. Zheng W, Shen H, Blaner WS, Zhao Q, Ren X, Graziano JH. Toxicol Appl Pharmacol. 1996;139(2):445–50.CrossRefPubMedPubMedCentralGoogle Scholar
  66. Zheng W, Aschner M, Ghersi-Egea JF. Toxicol Appl Pharmacol. 2003;192(1):1–11.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Molecular PharmacologyAlbert Einstein College of MedicineBronxUSA

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