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Heteromers Form Novel Signaling Complexes

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Book cover G-Protein-Coupled Receptor Dimers

Part of the book series: The Receptors ((REC,volume 33))

Abstract

Heteromers of G protein-coupled receptors offer the potential for a vast array of signaling partners. Research over the last decade has focused on identifying different heteromer complexes and their signaling components in an effort to understand their cellular and physiological functions. Heteromer complexes may serve a modulatory role or form completely novel signaling platforms within the cell. This chapter reviews canonical and biased signaling pathways of GPCR heteromers with a focus on their signaling capabilities and cellular localization.

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Author information

Authors and Affiliations

  1. Faculty of Health and Medical Sciences, Department of Veterinary Pre-Clinical Studies, University of Surrey, Daphne Jackson Road, Guildford, GU2 7XH, UK

    Peter J. McCormick Ph.D.

  2. School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK

    Joaquin Botta M.Sc

Authors
  1. Peter J. McCormick Ph.D.
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  2. Joaquin Botta M.Sc
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Corresponding author

Correspondence to Peter J. McCormick Ph.D. .

Editor information

Editors and Affiliations

  1. Department of Neuroscience and Experimental Therapeutics, Albany Medical College, Albany, New York, USA

    Katharine Herrick-Davis

  2. Centre for Translational Pharmacology, Institute of Molecular Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

    Graeme Milligan

  3. Department of Physiology and Biochemistry, University of Malta, Msida, Malta

    Giuseppe Di Giovanni

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McCormick, P.J., Botta, J. (2017). Heteromers Form Novel Signaling Complexes. In: Herrick-Davis, K., Milligan, G., Di Giovanni, G. (eds) G-Protein-Coupled Receptor Dimers. The Receptors, vol 33. Humana Press, Cham. https://doi.org/10.1007/978-3-319-60174-8_19

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