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Renal Handling of NaCl and Water

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Fluid, Electrolyte and Acid-Base Disorders

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Abstract

The kidneys filter about 180 L of plasma daily. Most of this plasma must be reclaimed in order to maintain fluid and electrolyte homeostasis. The protein-free ultrafiltrate is modified in composition as it passes through various segments of the nephron to form urine. Sodium (Na+) and its anion chloride (Cl−) are the major determinants of the extracellular fluid (ECF) volume, and both ions are effectively reabsorbed. Water reabsorption follows Na+ reabsorption in order to maintain normal osmolality in the ECF compartment. The proximal tubule is the major site of reclamation, whereas the other segments reclaim to a variable degree.

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Suggested Reading

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Rutgers New Jersey Medical, Newark, NJ, USA

    Alluru S. Reddi MD, PhD (Professor of Medicine, Chief)

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  1. Alluru S. Reddi MD, PhD
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Reddi, A.S. (2018). Renal Handling of NaCl and Water. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-60167-0_3

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  • DOI: https://doi.org/10.1007/978-3-319-60167-0_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60166-3

  • Online ISBN: 978-3-319-60167-0

  • eBook Packages: MedicineMedicine (R0)

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