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Hyperchloremic Metabolic Acidosis: Renal Tubular Acidosis

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Fluid, Electrolyte and Acid-Base Disorders

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Abstract

Renal tubular acidoses (RTAs) are discrete renal tubular disorders that are characterized by the inability to excrete H+ in the urine. As a result, there is a positive H+ balance, causing metabolic acidosis. The net acid excretion (NAE) is decreased, and some of the patients are unable to lower their urine pH <5.5. Despite severe acidosis, the anion gap (AG) remains normal because the decrease in serum [HCO3 −] is compensated for by a proportionate increase in serum [Cl−].

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Suggested Reading

  1. Batlle D, Haque SK. Genetic causes and mechanisms of distal renal tubular acidosis. Nephrol Dial Transplant. 2012;27:3691–704.

    Article  CAS  PubMed  Google Scholar 

  2. Golembiewska E, Ciechanowski K. Renal tubular acidosis-underrated problem? Acta Biochim Pol. 2012;59:213–7.

    CAS  PubMed  Google Scholar 

  3. Haque SK, Ariceta G, Batlle D. Proximal renal tubular acidosis: a not so rare disorder of multiple etiologies. Nephrol Dial Transplant. 2012;27:4273–87.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Izzedine H, Launay-Vacher V, Isnard-Bagnis C, et al. Drug-induced Fanconi syndrome. Am J Kidney Dis. 2003;41:292–309.

    Article  CAS  PubMed  Google Scholar 

  5. Karet FE. Mechanisms in hyperkalemic renal tubular acidosis. J Am Soc Nephrol. 2009;20:251–4.

    Article  CAS  PubMed  Google Scholar 

  6. Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8:589–601.

    Article  CAS  PubMed  Google Scholar 

  7. Moorthi KMLST, Batlle D. Renal tubular acidosis. In: Gennari FJ, Adrogué HJ, Galla JH, Madias NE, editors. Acid-base disorders and their treatment. Boca Raton: Taylor & Francis; 2005. p. 417–67.

    Chapter  Google Scholar 

  8. Reddy P. Clinical approach to renal tubular acidosis in adult patients. Int J Clin Pract. 2011;65:350–60.

    Article  CAS  PubMed  Google Scholar 

  9. Rodriguez-Soriano J. Renal tubular acidosis: the clinical entity. J Am Soc Nephrol. 2002;13:2160–70.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Nephrology and Hypertension, Rutgers New Jersey Medical, Newark, NJ, USA

    Alluru S. Reddi MD, PhD (Professor of Medicine, Chief)

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  1. Alluru S. Reddi MD, PhD
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Reddi, A.S. (2018). Hyperchloremic Metabolic Acidosis: Renal Tubular Acidosis. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-60167-0_29

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  • DOI: https://doi.org/10.1007/978-3-319-60167-0_29

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-60166-3

  • Online ISBN: 978-3-319-60167-0

  • eBook Packages: MedicineMedicine (R0)

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