Abstract
In the previous chapter, we presented various causes of high anion gap (AG) metabolic acidosis. For discussion purpose, these causes can be conveniently divided into the following categories:
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1.
Acidosis due to kidney injury
Acute kidney injury
Chronic kidney disease (CKD) stages 4–5
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2.
Acidosis due to accumulation of organic acids
l-Lactic acidosis
d-Lactic acidosis
Diabetic ketoacidosis
Alcoholic ketoacidosis
Starvation ketoacidosis
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3.
Acidosis due to toxins
Methanol
Ethylene glycol
Propylene glycol
Isopropyl alcohol
Salicylates
5-Oxoproline (pyroglutamic acid)
Paraldehyde
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Reference
Barceloux DG, Krenzelok EP, Olson K, et al. American academy of clinical toxicology practice guidelines on the treatment of ethylene glycol poisoning. J Toxicol Clin Toxicol. 1999;37:537–60.
Suggested Reading
Cerdá J, Tolwani AJ, Warnock DG. Critical care nephrology: management of acid-base disorders with CRRT. Kidney Int. 2012;82:9–18.
Fall PJ, Szerlip HM. Lactic acidosis: from sour milk to septic shock. J Intensive Care Med. 2005;20:255–71.
Fenves AZ, Kirkpatrick HM III, Patel VV, et al. Increased anion gap metabolic acidosis as a result of 5-oxoproline (pyroglutamic acid): a role for acetaminophen. Clin J Am Soc Nephrol. 2006;1:441–7.
Kraut JA, Madias NE. Treatment of acute metabolic acidosis: a pathophysiologic approach. Nat Rev Nephrol. 2012;8:589–601.
Kraut JA, Madias NE. Lactic acidosis. N Engl J Med. 2014;371:2309–19.
Kraut JA, Xing SX. Approach to the evaluation of a patient with an increased serum osmolal gap and high-anion gap metabolic acidosis. Am J Kidney Dis. 2011;58:480–4.
Kraut JA, Madias NE. Metabolic acidosis: pathophysiology, diagnosis and management. Nat Rev Nephrol. 2010;6:274–85.
Hood VL. Lactic acidosis. In: Jennari FJ, Adrogué HJ, Galla JH, Madias NE, editors. Acid-base disorders and their treatment. Boca Raton: Taylor & Francis; 2005. p. 351–82.
Laski ME, Wesson DE. Lactic acidosis. In: DuBose TH Jr, Hamm LL, editors. Acid-base and electrolyte disorders. A companion to Brenner & Rector’s the Kidney. Philadelphia: Saunders; 2002. p. 83–107.
Velez JC, Janech MG. A case of lactic acidosis induced by linezolid. Nat Rev Nephrol. 2010;6:236–40.
Kang KP, Lee S, Kang SK. D-lactic acidosis in humans: review of update. Electrolyte Blood Press. 2006;4:53–6.
Oh MS, Halperin ML. Toxin-induced metabolic acidosis. In: Jennari FJ, Adrogué HJ, Galla JH, Madias NE, editors. Acid-base disorders and their treatment. Boca Raton: Taylor & Francis; 2005. p. 383–415.
Wu D, Kraut JA. Role of NHE1in the cellular dysfunction of acute metabolic acidosis. Am J Nephrol. 2014;40:26–42.
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Reddi, A.S. (2018). High Anion Gap Metabolic Acidosis. In: Fluid, Electrolyte and Acid-Base Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-60167-0_28
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DOI: https://doi.org/10.1007/978-3-319-60167-0_28
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