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Genetics of Blood Pressure and Hypertension

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Book cover Disorders of Blood Pressure Regulation

Part of the book series: Updates in Hypertension and Cardiovascular Protection ((UHCP))

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Abstract

The genetic contribution to hypertension and blood pressure regulation is evident from twin studies, rare mutations causing monogenic blood pressure syndromes, and more recently emerging evidence from genome-wide association studies. The ongoing efforts to understand blood pressure genetics and the downstream molecular and physiological pathways highlight the complexity of the blood pressure phenotype and the major challenges that still need to be overcome to translate these findings into clinical applications that will benefit patients. The encouraging results from metabolomic profiling in hypertension indicate that these signals might be more tractable and integrating genomics and metabolomics may accelerate functional studies. In this chapter we describe the current state of the art in blood pressure and hypertension genomics and emerging insights from metabolomics.

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Author information

Authors and Affiliations

  1. BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Wolfson Medical School Building, University Avenue, Glasgow, G12 8QQ, UK

    Sandosh Padmanabhan, Li-En Tan & Anna F. Dominiczak

Authors
  1. Sandosh Padmanabhan
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  2. Li-En Tan
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  3. Anna F. Dominiczak
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Corresponding author

Correspondence to Anna F. Dominiczak .

Editor information

Editors and Affiliations

  1. Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

    Adel E. Berbari

  2. Emeritus Professor of Medicine, University of Milano-Bicocca, Monza, Italy

    Giuseppe Mancia

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Padmanabhan, S., Tan, LE., Dominiczak, A.F. (2018). Genetics of Blood Pressure and Hypertension. In: Berbari, A., Mancia, G. (eds) Disorders of Blood Pressure Regulation. Updates in Hypertension and Cardiovascular Protection. Springer, Cham. https://doi.org/10.1007/978-3-319-59918-2_10

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  • DOI: https://doi.org/10.1007/978-3-319-59918-2_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-59917-5

  • Online ISBN: 978-3-319-59918-2

  • eBook Packages: MedicineMedicine (R0)

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