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Introduction to Gastrointestinal Diseases Vol. 2 pp 27–38Cite as

Diagnostic Criteria in Peptic Ulcer Disease

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Abstract

The accurate detection of H. pylori, a major cause of peptic ulcer, is essential for managing infected patients. A number of invasive and noninvasive diagnostic methods are currently available. Tests differ in sensitivity and specificity, and the choice of which diagnostic method to use is highly personalized and influenced by clinical setting, cost, the pretest probability of infection, and the use of medications that generally reduce the density of bacteria and decrease the accuracy of test.

This chapter provides an overview of diagnostic tests used to identify H. pylori infection, depicts their general methodological aspects, and evaluates their validity and limitation in clinical practice.

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Abbreviations

CagA:

Cytotoxin-associated gene A

CO2 :

Carbon dioxide

EGD:

Esophagogastroduodenoscopy

EIA:

Enzyme immunoassay

ELISA:

Enzyme-linked immunosorbent assay

ESPGHAN:

European Society for Pediatric Gastroenterology, Hepatology, and Nutrition

FISH:

Fluorescence in situ hybridization

FDA:

Food and Drug Administration

FRET:

Fluorescence resonance energy transfer

ICA:

Immunochromatography

MALT:

Mucosa-associated lymphoid tissue

NASPGHAN:

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

PCR:

Polymerase chain reaction

PPI:

Proton pump inhibitor

RUT:

Rapid urease test

SAT:

Stool antigen test

UBT:

Urea breath test

VacA:

Vacuolating cytotoxin A

WB:

Western blot

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Acknowledgments

Supported by grant from the Medical University of Lodz (#502-03/1-156-04/502-14-343 to PM and #502-03/1-156-04/502-14-298 to MS), grant from National Science Centre (#UMO-2016/21/N/NZ5/01932 to PM and #UMO-2013/11/N/NZ7/02354 to MS), and Iuventus Plus program of the Polish Ministry of Science and Higher Education (IP2015 068774 to MS).

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland

    Paula Mosińska & Maciej Sałaga

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  1. Paula Mosińska
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  2. Maciej Sałaga
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Correspondence to Paula Mosińska or Maciej Sałaga .

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  1. Department of Biochemistry, Medical University of Lodz, Mazowiecka, Lodz, Poland

    Jakub Fichna

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Mosińska, P., Sałaga, M. (2017). Diagnostic Criteria in Peptic Ulcer Disease. In: Fichna, J. (eds) Introduction to Gastrointestinal Diseases Vol. 2. Springer, Cham. https://doi.org/10.1007/978-3-319-59885-7_4

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  • DOI: https://doi.org/10.1007/978-3-319-59885-7_4

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