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Pathophysiology and Risk Factors in Peptic Ulcer Disease

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Introduction to Gastrointestinal Diseases Vol. 2

Abstract

Understanding peptic ulcer disease (PUD) pathophysiology and risk factors influencing PUD course poses a great challenge. In this chapter the role of noxious and protective factors in pathophysiology of PUD are discussed. The impact of obesity, alcohol consumption, smoking, as well as genetic factors and use of NSAIDs are also presented. Nowadays, the effective therapies based on inhibition of gastric acid production and Helicobacter pylori eradication provide a gold standard in PUD treatment. Nonetheless, the role of all the abovementioned factors on PUD course should be considered during diagnosis and therapy. Thus, it is important to remember that PUD is a multifactorial disease, and its management should not be based on a simple cause-effect relationship but be tailored for an individual patient.

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Abbreviations

EGFR:

Epidermal growth factor receptor

H. pylori :

Helicobacter pylori

NO:

Nitric oxide

NSAIDs:

Nonsteroidal anti-inflammatory drugs

PG:

Prostaglandins

PUD:

Peptic ulcer disease

TGF-α:

Transforming growth factor-α

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Acknowledgments

Hubert Zatorski is the recipient of the Diamentowy Grant Program of the Polish Ministry of Science and Higher Education (No.0202/DIA/2015/44).

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215, Lodz, Poland

    Hubert Zatorski

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  1. Hubert Zatorski
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Correspondence to Hubert Zatorski .

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Editors and Affiliations

  1. Department of Biochemistry, Medical University of Lodz, Mazowiecka, Lodz, Poland

    Jakub Fichna

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Zatorski, H. (2017). Pathophysiology and Risk Factors in Peptic Ulcer Disease. In: Fichna, J. (eds) Introduction to Gastrointestinal Diseases Vol. 2. Springer, Cham. https://doi.org/10.1007/978-3-319-59885-7_2

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  • DOI: https://doi.org/10.1007/978-3-319-59885-7_2

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  • Online ISBN: 978-3-319-59885-7

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