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Peripheral Blood Biomarkers for Endometriosis

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Biomarkers for Endometriosis

Abstract

Endometriosis is a complex disease to study and diagnose. Ultrasound can be used to diagnose cysts and endometrioma but cannot rule out peritoneal endometriosis. Endometriosis is defined as endometrium outside of uterus. It is associated with infertility and pain. If we find a diagnostic test to diagnose endometriosis in blood it would be a convenient, most probably cheap test that would discriminate women who are suffering from endometriosis from those who do not. Till today, we do not have a diagnostic test for endometriosis. For women it is a heavy psychological burden, and quick diagnosis would help reduce this burden. Studies have shown that endometriosis cost arises predominantly from productivity loss and is predicted by decreased quality of life. In this chapter we describe and discuss the current status of biomarkers (miRNAs, glycoproteins, immunological, angiogenic, cell adhesion/invasion factors) of endometriosis in peripheral blood.

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Abbreviations

AUC:

Area under the curve

CA-125:

Cancer antigen

EDTA:

Ethylenediaminetetraacetic acid

EGF:

Soluble epidermal growth factor

ELISAs:

Enzyme-linked immunosorbent assays

HGF:

Hepatocyte growth factor

HIF-1 alpha:

Hypoxia-inducible factor-1 alpha

ICAM-1:

Intercellular adhesion molecule 1

IFN-Îł:

Interferon gamma

IL:

Interleukin

miRNAs:

microRNAs

MMPs:

Matrix metalloproteinase

MRI:

Magnetic resonance imaging

NPV:

Negative predictive value

PEDF:

Pigment epithelium-derived factor

PDGF:

Platelet-derived growth factor

PGF or PLGF:

Placental growth factor

SOPs:

Standard operating procedures

TNF-α:

Tumor necrosis factor

VEGF:

Vascular endothelial growth factor

VEGFR1:

Vascular endothelial growth factor receptor 1

VEGFR2:

Vascular endothelial growth factor receptor 2

WERF:

World Endometriosis Research Foundation

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Authors and Affiliations

  1. Department of Development and Regeneration, Organ Systems, KU Leuven, Leuven, Belgium

    Amelie Fassbender Ph.D. & Dorien O

  2. Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, UZ Gasthuisberg, 3000, Leuven, Belgium

    Amelie Fassbender Ph.D. & Dorien O

  3. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford, OX3 9DU, UK

    Christian M. Becker M.D.

  4. Endometriosis Care Centre Oxford, University of Oxford, Oxford, OX3 9DU, UK

    Christian M. Becker M.D.

  5. Department of Development and Regeneration, Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium

    Thomas D’Hooghe M.D., Ph.D.

  6. Global Medical Affairs Fertility, Research and Development, Merck KGaA, Darmstadt, Germany

    Thomas D’Hooghe M.D., Ph.D.

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  1. Amelie Fassbender Ph.D.
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  3. Christian M. Becker M.D.
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Correspondence to Thomas D’Hooghe M.D., Ph.D. .

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  1. Department of Development and Regeneration Organ Systems, Group Biomedical Sciences, KU Leuven (University of Leuven), Leuven, Belgium

    Thomas D'Hooghe

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Fassbender, A., O, D., Becker, C.M., D’Hooghe, T. (2017). Peripheral Blood Biomarkers for Endometriosis. In: D'Hooghe, T. (eds) Biomarkers for Endometriosis. Springer, Cham. https://doi.org/10.1007/978-3-319-59856-7_7

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